Single-specificity anti-Ku antibodies in an international cohort of 2140 systemic sclerosis subjects: clinical associations

• Published in: Medicine (Baltimore) Vol. 95; no. 35; p. e4713
• Main Authors: Hoa, S., Hudson, M., Troyanov, Y., Proudman, S., Walker, J., Stevens, W., Nikpour, M., Assassi, S., Mayes, M.D., Wang, M., Baron, M., Fritzler, M.J.
• Format: Journal Article
• Language: English
• Published: United States The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved 01.08.2016; Wolters Kluwer Health
• Subjects: Arthritis - epidemiology; Autoantibodies - blood; Comorbidity; Female; Humans; Hypertension, Pulmonary - epidemiology; Ku Autoantigen - immunology; Lung Diseases, Interstitial - epidemiology; Male; Middle Aged; Myositis - epidemiology; Observational Study; Prevalence; Retrospective Studies; Scleroderma, Systemic - epidemiology; Scleroderma, Systemic - immunology

Autoantibodies directed against the Ku autoantigen are present in systemic sclerosis (SSc) and have been associated with myositis overlap and interstitial lung disease (ILD). However, there is a paucity of data on the clinical correlates of anti-Ku antibodies in the absence of other SSc-specific ant...