Insulin Sensitivity and the Effects of Insulin on Renal Sodium Handling and Pressor Systems in Essential Hypertensive Patients

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 23; no. 1 Suppl I; pp. I-29 - I-33
• Main Authors: Shimamoto, Kazuaki, Hirata, Akifumi, Fukuoka, Masatada, Higashiura, Katsuhiro, Miyazaki, Yoshinori, Shiiki, Mamoru, Masuda, Atsushi, Nakagawa, Motoya, Iimura, Osamu
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.01.1994; Hagerstown, MD Lippincott
• Subjects: Aldosterone - blood; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - drug effects; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Female; Glucose Clamp Technique; Heart Rate - drug effects; Humans; Hypertension - blood; Hypertension - physiopathology; Hypertension - urine; Infusions, Intravenous; Insulin - administration & dosage; Insulin - pharmacology; Insulin Resistance; Kinetics; Male; Medical sciences; Middle Aged; Natriuresis - drug effects; Norepinephrine - blood; Reference Values; Renin - blood; Sodium - urine; Time Factors; Human; Hypertension; Hyperinsulinemia; Pancreatic hormone; Glucose clamp technique; Natriuria; Cardiovascular disease; Exploration; Essential; Insulin; Japanese; Protein hormone; Sensitivity resistance

Insulin resistance and hyperinsulinemia are linked with essential hypertension. To clarify insulin sensitivity in Japanese essential hypertensive patients and the role of insulin resistance in these patients, a euglycemic hyperinsulinemic glucose clamp was applied in 17 essential hypertensive patien...