Effect of combined ursodeoxycholic acid and glucocorticoid on the outcome of Kasai procedure: A systematic review and meta-analysis

• Published in: Medicine (Baltimore) Vol. 97; no. 35; p. e12005
• Main Authors: Qiu, Jian-Li, Shao, Ming-Yi, Xie, Wen-Fang, Li, Yue, Yang, Hai-Die, Niu, Min-Min, Xu, Hua
• Format: Journal Article
• Language: English
• Published: United States The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved 01.08.2018; Wolters Kluwer Health
• Subjects: Biliary Atresia - blood; Biliary Atresia - surgery; Bilirubin - blood; Cholagogues and Choleretics - administration & dosage; Drug Therapy, Combination; Female; Glucocorticoids - administration & dosage; Humans; Infant; Infant, Newborn; Jaundice - etiology; Jaundice - prevention & control; Male; Portoenterostomy, Hepatic - adverse effects; Portoenterostomy, Hepatic - methods; Postoperative Complications - etiology; Postoperative Complications - prevention & control; Systematic Review and Meta-Analysis; Treatment Outcome; Ursodeoxycholic Acid - administration & dosage

Multiple studies have investigated the effect of ursodeoxycholic acid (UDCA) or glucocorticoid (GC) on the outcome of the hepatoportoenterostomy (Kasai procedure) in patients with biliary atresia (BA). However, the combined effect of these drugs (UDCA + GC) is little understood. This meta-analysis s...