Lycoperoside H, a steroidal alkaloid saponin in tomato seeds, ameliorates atopic dermatitis‐like symptoms in IL‐33 transgenic mice

• Published in: Journal of food biochemistry Vol. 45; no. 9; pp. e13877 - n/a
• Main Authors: Takeda, Shogo, Miyasaka, Kenchi, Shimoda, Hiroshi
• Format: Journal Article
• Language: English
• Published: 01.09.2021
• Subjects: anti-allergic agents; atopic dermatitis; blood serum; eosinophils; hyperplasia; IL‐33; inflammation; interleukins; lycoperoside; mice; oral administration; seed extracts; steroid alkaloids; steroid saponins; steroidal saponin; tomato seed; tomatoes; transepidermal water loss

Tomato seeds contain steroidal saponins called lycoperosides. However, it currently remains unclear whether lycoperosides exert anti‐inflammatory or anti‐allergic effects. Therefore, we herein investigated the effects of tomato seed extract (TSE) and lycoperoside H (LH) in Interleukin (IL)‐33 transg...