A Causal Role of Genetically Elevated Circulating Interleukin-10 in the Development of Digestive Cancers: Evidence from Mendelian Randomization Analysis Based on 29,307 Subjects

• Published in: Medicine (Baltimore) Vol. 95; no. 7; p. e2799
• Main Authors: Niu, Wenquan, Pang, Qing, Lin, Ting, Wang, Zhixin, Zhang, Jingyao, Tai, Minghui, Zhang, Lingqiang, Zhang, Li, Gu, Mingliang, Liu, Chang, Qu, Kai
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc. All rights reserved 01.02.2016; Wolters Kluwer Health
• Subjects: Digestive System Neoplasms - blood; Digestive System Neoplasms - genetics; Humans; Interleukin-10 - blood; Interleukin-10 - genetics; Mendelian Randomization Analysis; Regression Analysis; Systematic Reviewand Meta-Analysis

Recent studies have observed a high level of circulating interleukin-10 (IL-10) in patients with digestive cancers, yet whether elevated IL-10 is causally associated with digestive cancers so far remained unresolved. We therefore meta-analyzed available observational studies with Mendelian randomiza...