A Causal Role of Genetically Elevated Circulating Interleukin-10 in the Development of Digestive Cancers: Evidence from Mendelian Randomization Analysis Based on 29,307 Subjects

Recent studies have observed a high level of circulating interleukin-10 (IL-10) in patients with digestive cancers, yet whether elevated IL-10 is causally associated with digestive cancers so far remained unresolved. We therefore meta-analyzed available observational studies with Mendelian randomiza...

Full description

Saved in:
Bibliographic Details
Published inMedicine (Baltimore) Vol. 95; no. 7; p. e2799
Main Authors Niu, Wenquan, Pang, Qing, Lin, Ting, Wang, Zhixin, Zhang, Jingyao, Tai, Minghui, Zhang, Lingqiang, Zhang, Li, Gu, Mingliang, Liu, Chang, Qu, Kai
Format Journal Article
LanguageEnglish
Published United States Wolters Kluwer Health, Inc. All rights reserved 01.02.2016
Wolters Kluwer Health
Subjects
Digestive System Neoplasms - blood
Digestive System Neoplasms - genetics
Humans
Interleukin-10 - blood
Interleukin-10 - genetics
Mendelian Randomization Analysis
Regression Analysis
Systematic Reviewand Meta-Analysis
Online AccessGet full text

Cover

Abstract Recent studies have observed a high level of circulating interleukin-10 (IL-10) in patients with digestive cancers, yet whether elevated IL-10 is causally associated with digestive cancers so far remained unresolved. We therefore meta-analyzed available observational studies with Mendelian randomization method to explore this causal association by employing IL-10 gene 3 variants (-592C>A, -819C>T, and -1082A>G) as instruments. Data were available from 52 articles encompassing 29,307 subjects. Subgroup analysis by cancer type indicated that -1082A>G was associated with increased risk of gastric cancer (odds ratio [OR] = 1.19; 95% confidence interval [CI]: 1.05-1.35; P = 0.006), and the association was reinforced for intestinal type gastric cancer (OR = 1.26; 95%CI: 1.09-1.44; P = 0.001). By ethnicity, risk estimate for -1082G allele carriers was increased by 21% for digestive cancers in East Asians (95%CI: 1.05-1.40; P = 0.009). As for the genotype-phenotype association, carriers of -1082G allele had an overall 20.21 pg/mL higher IL-10 level than those with -1082AA genotype (P = 0.023). In further Mendelian randomization analysis, the predicted OR for 10 pg/mL increment in IL-10 was 1.14 (95%CI: 1.01-16.99) in gastric cancer. Our findings provided evidence for a causal role of genetically elevated IL-10 in the development of gastric cancer, especially in East Asians and for intestinal type gastric cancer.
AbstractList Recent studies have observed a high level of circulating interleukin-10 (IL-10) in patients with digestive cancers, yet whether elevated IL-10 is causally associated with digestive cancers so far remained unresolved. We therefore meta-analyzed available observational studies with Mendelian randomization method to explore this causal association by employing IL-10 gene 3 variants (-592C>A, -819C>T, and -1082A>G) as instruments. Data were available from 52 articles encompassing 29,307 subjects. Subgroup analysis by cancer type indicated that -1082A>G was associated with increased risk of gastric cancer (odds ratio [OR] = 1.19; 95% confidence interval [CI]: 1.05-1.35; P = 0.006), and the association was reinforced for intestinal type gastric cancer (OR = 1.26; 95%CI: 1.09-1.44; P = 0.001). By ethnicity, risk estimate for -1082G allele carriers was increased by 21% for digestive cancers in East Asians (95%CI: 1.05-1.40; P = 0.009). As for the genotype-phenotype association, carriers of -1082G allele had an overall 20.21 pg/mL higher IL-10 level than those with -1082AA genotype (P = 0.023). In further Mendelian randomization analysis, the predicted OR for 10 pg/mL increment in IL-10 was 1.14 (95%CI: 1.01-16.99) in gastric cancer. Our findings provided evidence for a causal role of genetically elevated IL-10 in the development of gastric cancer, especially in East Asians and for intestinal type gastric cancer.
Supplemental Digital Content is available in the text Recent studies have observed a high level of circulating interleukin-10 (IL-10) in patients with digestive cancers, yet whether elevated IL-10 is causally associated with digestive cancers so far remained unresolved. We therefore meta-analyzed available observational studies with Mendelian randomization method to explore this causal association by employing IL-10 gene 3 variants (-592C>A, -819C>T, and -1082A>G) as instruments. Data were available from 52 articles encompassing 29,307 subjects. Subgroup analysis by cancer type indicated that -1082A>G was associated with increased risk of gastric cancer (odds ratio [OR] = 1.19; 95% confidence interval [CI]: 1.05–1.35; P  = 0.006), and the association was reinforced for intestinal type gastric cancer (OR = 1.26; 95%CI: 1.09–1.44; P  = 0.001). By ethnicity, risk estimate for -1082G allele carriers was increased by 21% for digestive cancers in East Asians (95%CI: 1.05–1.40; P  = 0.009). As for the genotype–phenotype association, carriers of -1082G allele had an overall 20.21 pg/mL higher IL-10 level than those with -1082AA genotype ( P  = 0.023). In further Mendelian randomization analysis, the predicted OR for 10 pg/mL increment in IL-10 was 1.14 (95%CI: 1.01–16.99) in gastric cancer. Our findings provided evidence for a causal role of genetically elevated IL-10 in the development of gastric cancer, especially in East Asians and for intestinal type gastric cancer.
Recent studies have observed a high level of circulating interleukin-10 (IL-10) in patients with digestive cancers, yet whether elevated IL-10 is causally associated with digestive cancers so far remained unresolved. We therefore meta-analyzed available observational studies with Mendelian randomization method to explore this causal association by employing IL-10 gene 3 variants (-592C>A, -819C>T, and -1082A>G) as instruments. Data were available from 52 articles encompassing 29,307 subjects. Subgroup analysis by cancer type indicated that -1082A>G was associated with increased risk of gastric cancer (odds ratio [OR] = 1.19; 95% confidence interval [CI]: 1.05-1.35; P = 0.006), and the association was reinforced for intestinal type gastric cancer (OR = 1.26; 95%CI: 1.09-1.44; P = 0.001). By ethnicity, risk estimate for -1082G allele carriers was increased by 21% for digestive cancers in East Asians (95%CI: 1.05-1.40; P = 0.009). As for the genotype-phenotype association, carriers of -1082G allele had an overall 20.21 pg/mL higher IL-10 level than those with -1082AA genotype (P = 0.023). In further Mendelian randomization analysis, the predicted OR for 10 pg/mL increment in IL-10 was 1.14 (95%CI: 1.01-16.99) in gastric cancer. Our findings provided evidence for a causal role of genetically elevated IL-10 in the development of gastric cancer, especially in East Asians and for intestinal type gastric cancer.Recent studies have observed a high level of circulating interleukin-10 (IL-10) in patients with digestive cancers, yet whether elevated IL-10 is causally associated with digestive cancers so far remained unresolved. We therefore meta-analyzed available observational studies with Mendelian randomization method to explore this causal association by employing IL-10 gene 3 variants (-592C>A, -819C>T, and -1082A>G) as instruments. Data were available from 52 articles encompassing 29,307 subjects. Subgroup analysis by cancer type indicated that -1082A>G was associated with increased risk of gastric cancer (odds ratio [OR] = 1.19; 95% confidence interval [CI]: 1.05-1.35; P = 0.006), and the association was reinforced for intestinal type gastric cancer (OR = 1.26; 95%CI: 1.09-1.44; P = 0.001). By ethnicity, risk estimate for -1082G allele carriers was increased by 21% for digestive cancers in East Asians (95%CI: 1.05-1.40; P = 0.009). As for the genotype-phenotype association, carriers of -1082G allele had an overall 20.21 pg/mL higher IL-10 level than those with -1082AA genotype (P = 0.023). In further Mendelian randomization analysis, the predicted OR for 10 pg/mL increment in IL-10 was 1.14 (95%CI: 1.01-16.99) in gastric cancer. Our findings provided evidence for a causal role of genetically elevated IL-10 in the development of gastric cancer, especially in East Asians and for intestinal type gastric cancer.
Author Qu, Kai
Wang, Zhixin
Niu, Wenquan
Tai, Minghui
Zhang, Lingqiang
Zhang, Li
Lin, Ting
Zhang, Jingyao
Pang, Qing
Gu, Mingliang
Liu, Chang
AuthorAffiliation From the State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai (WN); Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province (QP, TL, ZW, JZ, MT, LZ, CL, KQ); Department of Hepatobiliary Surgery, The Affiliated Hospital of Qinghai University, Xining, Qinghai (ZW, LZ); Department of Ultrasound Diagnostics, The First Affiliated Hospital of Xi’an Jiaotong University (MT); Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province (LZ); and Chinese Academy of Sciences Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics (MG), Chinese Academy of Sciences, Beijing, China
AuthorAffiliation_xml – name: From the State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai (WN); Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province (QP, TL, ZW, JZ, MT, LZ, CL, KQ); Department of Hepatobiliary Surgery, The Affiliated Hospital of Qinghai University, Xining, Qinghai (ZW, LZ); Department of Ultrasound Diagnostics, The First Affiliated Hospital of Xi’an Jiaotong University (MT); Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province (LZ); and Chinese Academy of Sciences Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics (MG), Chinese Academy of Sciences, Beijing, China
Author_xml – sequence: 1
  givenname: Wenquan
  surname: Niu
  fullname: Niu, Wenquan
  organization: From the State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai (WN); Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province (QP, TL, ZW, JZ, MT, LZ, CL, KQ); Department of Hepatobiliary Surgery, The Affiliated Hospital of Qinghai University, Xining, Qinghai (ZW, LZ); Department of Ultrasound Diagnostics, The First Affiliated Hospital of Xi’an Jiaotong University (MT); Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province (LZ); and Chinese Academy of Sciences Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics (MG), Chinese Academy of Sciences, Beijing, China
– sequence: 2
  givenname: Qing
  surname: Pang
  fullname: Pang, Qing
– sequence: 3
  givenname: Ting
  surname: Lin
  fullname: Lin, Ting
– sequence: 4
  givenname: Zhixin
  surname: Wang
  fullname: Wang, Zhixin
– sequence: 5
  givenname: Jingyao
  surname: Zhang
  fullname: Zhang, Jingyao
– sequence: 6
  givenname: Minghui
  surname: Tai
  fullname: Tai, Minghui
– sequence: 7
  givenname: Lingqiang
  surname: Zhang
  fullname: Zhang, Lingqiang
– sequence: 8
  givenname: Li
  surname: Zhang
  fullname: Zhang, Li
– sequence: 9
  givenname: Mingliang
  surname: Gu
  fullname: Gu, Mingliang
– sequence: 10
  givenname: Chang
  surname: Liu
  fullname: Liu, Chang
– sequence: 11
  givenname: Kai
  surname: Qu
  fullname: Qu, Kai
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26886630$$D View this record in MEDLINE/PubMed
BookMark eNqFUsFuEzEQXaEimha-AAn5yIEttnfXXnNACkkolRohFThbXns2ceu1w3o3Vfgr_hCnKVXpBV9szbz3ZvxmTrIjHzxk2WuCzwgW_P1yfoYfHcqFeJZNSFWwvBKsPMomKVjlXPDyODuJ8RpjUnBavsiOKatrxgo8yX5P0UyNUTl0FRyg0KJz8DBYrZzboYWDrRrAoJnt9ejUYP0KXfgBegfjjfU5wch6NKwBzWELLmw68MNeZW5XEAe7hSTvNfTxA1psrYH0Rm0fOrQEb8BZ5dGV8iZ09ldSDx5NvXK7aCP6pGIqnCJUvCswR9_G5hr0EF9mz1vlIry6v0-zH58X32df8suv5xez6WWuS1zxvAIjGtNA2VLGSYlpaygWtTacGaKKotG4UG3DKy2SLYTg2oDRTcmgrbhu6-I0-3jQ3YxNl1LpY71yctPbTvU7GZSV_2a8XctV2MpSiDp5mwTe3gv04eeY3JCdjRqcUx7CGCXhjGNOK7aHvnlc66HI3zklQHEA6D7E2EP7ACFY7rdBLufy6TYklnjC0na4szk1bN1_uOWBextcmne8ceMt9HINyg3rO3jFBc0pJgxTUuE8RQpe_AExVMrV
CitedBy_id crossref_primary_10_1007_s40471_018_0144_1
crossref_primary_10_1016_j_biopha_2020_110578
crossref_primary_10_1016_j_ebiom_2024_104991
crossref_primary_10_1002_tox_24147
crossref_primary_10_1016_j_jcmgh_2017_03_005
crossref_primary_10_1002_path_5421
Cites_doi 10.1007/s10552-005-0439-7
10.1002/cncr.20842
10.3748/wjg.v11.i6.858
10.4049/jimmunol.180.9.5771
10.1371/journal.pmed.1000097
10.1089/rej.2008.0678
10.1002/cncr.26726
10.1016/j.humimm.2009.01.019
10.1093/carcin/bgh349
10.1097/MEG.0b013e328343b7f5
10.1245/s10434-006-9122-9
10.1080/00365520601106699
10.1016/S0009-9236(97)90065-5
10.1111/j.1365-2370.1997.tb00001.x
10.1007/s10620-012-2460-5
10.1097/01.sla.0000149300.28588.23
10.1097/MCG.0b013e318178d1d3
10.1089/dna.2011.1440
10.1093/carcin/bgn286
10.1093/mutage/ger078
10.1158/1055-9965.1547.13.9
10.1002/ijc.21364
10.1007/s10238-005-0082-3
10.1111/j.1349-7006.2010.01795.x
10.1089/gtmb.2011.0078
10.1158/1055-9965.EPI-04-0878
10.1007/s12029-008-9016-0
10.1186/1471-2407-12-183
10.1385/IJGC:34:1:19
10.1007/s10552-009-9427-7
10.7314/APJCP.2013.14.6.3443
10.1371/journal.pmed.1001713
10.1136/bmj.327.7414.557
10.1016/j.ijcard.2011.12.098
10.1038/srep05335
10.1006/cyto.1995.1001
10.3945/jn.108.101865
10.7314/APJCP.2014.15.16.6961
10.1158/1055-9965.EPI-06-0042
10.1158/0008-5472.CAN-08-0444
10.1007/s11010-010-0616-1
10.1093/carcin/bgn164
10.1016/S0016-5085(03)00157-4
10.1016/j.humimm.2007.05.002
10.1016/j.jhep.2004.11.026
10.1128/MCB.00413-12
10.1093/hmg/ddg104
10.1007/s11010-011-1149-y
10.1155/2012/804173
10.1053/j.gastro.2012.07.009
10.1002/ijc.24666
10.1111/j.1440-1746.2006.04613.x
10.1111/j.1572-0241.2007.01423.x
10.1007/s10120-009-0509-8
10.1111/j.1749-6632.2008.03686.x
10.1196/annals.1386.002
10.1093/annonc/mdn400
10.1371/journal.pone.0029643
10.3109/10428194.2012.682307
10.1186/1471-2288-11-41
10.1016/j.canlet.2004.11.028
10.7314/APJCP.2013.14.4.2577
10.1002/ijc.10987
10.1097/01.TP.0000055216.19866.9A
10.1016/j.cyto.2004.10.013
10.1111/j.1399-0039.2006.00536.x
10.3748/wjg.v17.i10.1362
10.1016/j.cgh.2006.05.025
10.7754/Clin.Lab.2012.120713
10.1016/j.canep.2011.01.005
ContentType Journal Article
Copyright Wolters Kluwer Health, Inc. All rights reserved.
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. 2016
Copyright_xml – notice: Wolters Kluwer Health, Inc. All rights reserved.
– notice: Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. 2016
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1097/MD.0000000000002799
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1536-5964
EndPage e2799
ExternalDocumentID PMC4998630
26886630
10_1097_MD_0000000000002799
00005792-201602150-00037
Genre Meta-Analysis
Review
Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
.-D
.XZ
.Z2
01R
0R~
354
40H
4Q1
4Q2
4Q3
5GY
5RE
5VS
71W
77Y
7O~
AAAAV
AAGIX
AAHPQ
AAIQE
AAMOA
AAQKA
AARTV
AASCR
AAWTL
AAXQO
AAYEP
ABASU
ABBUW
ABCQX
ABDIG
ABFRF
ABOCM
ABVCZ
ABXVJ
ABZAD
ABZZY
ACDDN
ACEWG
ACGFO
ACGFS
ACILI
ACLDA
ACWDW
ACWRI
ACXJB
ACXNZ
ACZKN
ADGGA
ADHPY
ADNKB
ADPDF
AE6
AEFWE
AENEX
AFBFQ
AFDTB
AGOPY
AHOMT
AHQNM
AHVBC
AIJEX
AINUH
AJCLO
AJIOK
AJNWD
AJNYG
AJZMW
AKCTQ
AKULP
ALKUP
ALMA_UNASSIGNED_HOLDINGS
ALMTX
AMJPA
AMKUR
AMNEI
AOHHW
AOQMC
BQLVK
CS3
DIWNM
DU5
E.X
EBS
EEVPB
EJD
ERAAH
EX3
F2K
F2L
F2M
F2N
F5P
FCALG
FD6
FIJ
FL-
GNXGY
GQDEL
GROUPED_DOAJ
H0~
HLJTE
HYE
HZ~
H~9
IKREB
IKYAY
IN~
IPNFZ
JK3
JK8
K8S
KD2
KMI
KQ8
L-C
N9A
N~7
N~B
O9-
OAG
OAH
OB2
OHH
OK1
OL1
OLB
OLG
OLH
OLU
OLV
OLY
OLZ
OPUJH
OUVQU
OVD
OVDNE
OVEED
OVIDH
OVLEI
OWV
OWW
OWZ
OXXIT
P2P
RIG
RLZ
RPM
RXW
S4R
S4S
TAF
TEORI
TSPGW
UNMZH
V2I
VVN
W3M
WOQ
WOW
X3V
X3W
XYM
YFH
YOC
ZFV
ZY1
.3C
.55
.GJ
1CY
53G
AAYXX
ADFPA
ADGHP
AE3
AFFNX
AFUWQ
AHRYX
BS7
BYPQX
CITATION
FW0
JF9
JG8
N4W
N~M
OCUKA
ODA
ORVUJ
OWU
P-K
R58
T8P
X7M
XXN
ZGI
ZXP
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
ADSXY
ID FETCH-LOGICAL-c4057-5ed9bdbe4f2671402fd2098cd76d1a33bc03afb75c90131108dedcb46ef57cf83
ISSN 0025-7974
1536-5964
IngestDate Thu Aug 21 18:08:22 EDT 2025
Thu Jul 10 18:00:13 EDT 2025
Mon Jul 21 06:03:51 EDT 2025
Tue Jul 01 01:21:24 EDT 2025
Thu Apr 24 23:05:25 EDT 2025
Fri May 16 04:11:53 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7
Language English
License This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c4057-5ed9bdbe4f2671402fd2098cd76d1a33bc03afb75c90131108dedcb46ef57cf83
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
OpenAccessLink http://dx.doi.org/10.1097/MD.0000000000002799
PMID 26886630
PQID 1767072560
PQPubID 23479
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4998630
proquest_miscellaneous_1767072560
pubmed_primary_26886630
crossref_primary_10_1097_MD_0000000000002799
crossref_citationtrail_10_1097_MD_0000000000002799
wolterskluwer_health_00005792-201602150-00037
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2016-February-01
PublicationDateYYYYMMDD 2016-02-01
PublicationDate_xml – month: 02
  year: 2016
  text: 2016-February-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Medicine (Baltimore)
PublicationTitleAlternate Medicine (Baltimore)
PublicationYear 2016
Publisher Wolters Kluwer Health, Inc. All rights reserved
Wolters Kluwer Health
Publisher_xml – name: Wolters Kluwer Health, Inc. All rights reserved
– name: Wolters Kluwer Health
References Burada (R17-37-20210226) 2013; 59
Niu (R7-37-20210226) 2012; 157
Jung (R67-37-20210226) 2012; 32
Bouzgarrou (R15-37-20210226) 2009; 70
Tsilidis (R57-37-20210226) 2009; 20
Bowden (R10-37-20210226) 2011; 11
Dicken (R71-37-20210226) 2005; 241
Lee (R37-37-20210226) 2005; 225
Migita (R42-37-20210226) 2005; 42
Sicinschi (R52-37-20210226) 2006; 118
Crusius (R21-37-20210226) 2008; 19
Zhou (R62-37-20210226) 2011; 347
Kim (R35-37-20210226) 2012; 7
Kube (R70-37-20210226) 1995; 7
Zeng (R61-37-20210226) 2012; 362
Andersen (R12-37-20210226) 2012; 12
Kole (R64-37-20210226) 2014; 380
Li (R72-37-20210226) 2014; 4
Kamangar (R33-37-20210226) 2006; 17
Wang (R74-37-20210226) 2012; 27
Heneghan (R31-37-20210226) 2003; 34
Wu (R59-37-20210226) 2003; 104
Yri (R1-37-20210226) 2012; 53
de Oliveira (R22-37-20210226) 2013; 58
Crivello (R20-37-20210226) 2006; 1089
Ni (R73-37-20210226) 2012; 31
Turner (R5-37-20210226) 1997; 24
Shin (R50-37-20210226) 2011; 23
Ma (R68-37-20210226) 2011; 102
Forte (R25-37-20210226) 2008; 11
Giacomelli (R65-37-20210226) 2003; 9
Burada (R16-37-20210226) 2012; 26
Deans (R23-37-20210226) 2007; 14
Li (R38-37-20210226) 2011; 35
Scola (R49-37-20210226) 2009; 1155
Talseth (R55-37-20210226) 2007; 42
Bei (R14-37-20210226) 2014; 15
Chiba (R2-37-20210226) 2012; 143
Nieters (R44-37-20210226) 2005; 103
Huhn (R69-37-20210226) 1997; 62
Ko (R36-37-20210226) 2009; 139
Vishnoi (R58-37-20210226) 2007; 38
Proitsi (R6-37-20210226) 2014; 11
Zambon (R60-37-20210226) 2005; 29
Shin (R51-37-20210226) 2003; 12
Pan (R46-37-20210226) 2013; 14
Garcia-Gonzalez (R26-37-20210226) 2007; 102
Cozar (R19-37-20210226) 2007; 68
Suarez (R4-37-20210226) 2003; 75
Liu (R39-37-20210226) 2011; 17
Alpizar-Alpizar (R11-37-20210226) 2005; 5
Ikeguchi (R3-37-20210226) 2009; 12
Ando (R13-37-20210226) 2009; 125
Cacev (R18-37-20210226) 2008; 29
Savage (R47-37-20210226) 2004; 13
Couper (R63-37-20210226) 2008; 180
Gunter (R28-37-20210226) 2006; 15
Higgins (R9-37-20210226) 2003; 327
Chan (R66-37-20210226) 2012; 118
Lu (R40-37-20210226) 2005; 26
Saxena (R48-37-20210226) 2014; 139
Tseng (R56-37-20210226) 2006; 67
Ognjanovic (R45-37-20210226) 2009; 30
Guo (R29-37-20210226) 2005; 11
Sun (R54-37-20210226) 2013; 14
Moher (R8-37-20210226) 2009; 6
El-Omar (R24-37-20210226) 2003; 124
Gonzalez-Hormazabal (R27-37-20210226) 2014; 34
He (R30-37-20210226) 2012; 16
Sugimoto (R53-37-20210226) 2007; 22
Hsing (R32-37-20210226) 2008; 68
Macarthur (R41-37-20210226) 2005; 14
Morgan (R43-37-20210226) 2006; 4
Kang (R34-37-20210226) 2009; 43
References_xml – volume: 17
  start-page: 117
  year: 2006
  ident: R33-37-20210226
  article-title: Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland)
  publication-title: Cancer Causes Control
  doi: 10.1007/s10552-005-0439-7
– volume: 103
  start-page: 740
  year: 2005
  ident: R44-37-20210226
  article-title: Effect of cytokine genotypes on the hepatitis B virus-hepatocellular carcinoma association
  publication-title: Cancer
  doi: 10.1002/cncr.20842
– volume: 11
  start-page: 858
  year: 2005
  ident: R29-37-20210226
  article-title: Interleukin-10-1082 promoter polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high-incidence region of north China
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v11.i6.858
– volume: 180
  start-page: 5771
  year: 2008
  ident: R63-37-20210226
  article-title: IL-10: the master regulator of immunity to infection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.9.5771
– volume: 6
  start-page: e1000097
  year: 2009
  ident: R8-37-20210226
  article-title: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.1000097
– volume: 11
  start-page: 509
  year: 2008
  ident: R25-37-20210226
  article-title: Role of environmental and genetic factor interaction in age-related disease development: the gastric cancer paradigm
  publication-title: Rejuvenation Res
  doi: 10.1089/rej.2008.0678
– volume: 118
  start-page: 3984
  year: 2012
  ident: R66-37-20210226
  article-title: A study of circulating interleukin 10 in prognostication of unresectable hepatocellular carcinoma
  publication-title: Cancer
  doi: 10.1002/cncr.26726
– volume: 70
  start-page: 230
  year: 2009
  ident: R15-37-20210226
  article-title: Combined analysis of interferon-gamma and interleukin-10 gene polymorphisms and chronic hepatitis C severity
  publication-title: Hum Immunol
  doi: 10.1016/j.humimm.2009.01.019
– volume: 26
  start-page: 631
  year: 2005
  ident: R40-37-20210226
  article-title: Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgh349
– volume: 23
  start-page: 411
  year: 2011
  ident: R50-37-20210226
  article-title: Intrafamilial aggregation of gastric cancer: a comprehensive approach including environmental factors, Helicobacter pylori virulence, and genetic susceptibility
  publication-title: Eur J Gastroenterol Hepatol
  doi: 10.1097/MEG.0b013e328343b7f5
– volume: 14
  start-page: 329
  year: 2007
  ident: R23-37-20210226
  article-title: Host cytokine genotype is related to adverse prognosis and systemic inflammation in gastro-oesophageal cancer
  publication-title: Ann Surg Oncol
  doi: 10.1245/s10434-006-9122-9
– volume: 42
  start-page: 628
  year: 2007
  ident: R55-37-20210226
  article-title: Lack of association between genetic polymorphisms in cytokine genes and disease expression in patients with hereditary non-polyposis colorectal cancer
  publication-title: Scand J Gastroenterol
  doi: 10.1080/00365520601106699
– volume: 62
  start-page: 171
  year: 1997
  ident: R69-37-20210226
  article-title: Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers
  publication-title: Clin Pharmacol Ther
  doi: 10.1016/S0009-9236(97)90065-5
– volume: 24
  start-page: 1
  year: 1997
  ident: R5-37-20210226
  article-title: An investigation of polymorphism in the interleukin-10 gene promoter
  publication-title: Eur J Immunogenet
  doi: 10.1111/j.1365-2370.1997.tb00001.x
– volume: 58
  start-page: 978
  year: 2013
  ident: R22-37-20210226
  article-title: Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer
  publication-title: Dig Dis Sci
  doi: 10.1007/s10620-012-2460-5
– volume: 241
  start-page: 27
  year: 2005
  ident: R71-37-20210226
  article-title: Gastric adenocarcinoma: review and considerations for future directions
  publication-title: Ann Surg
  doi: 10.1097/01.sla.0000149300.28588.23
– volume: 43
  start-page: 420
  year: 2009
  ident: R34-37-20210226
  article-title: The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea
  publication-title: J Clin Gastroenterol
  doi: 10.1097/MCG.0b013e318178d1d3
– volume: 31
  start-page: 582
  year: 2012
  ident: R73-37-20210226
  article-title: A meta-analysis of interleukin-10-1082 promoter polymorphism associated with gastric cancer risk
  publication-title: DNA Cell Biol
  doi: 10.1089/dna.2011.1440
– volume: 30
  start-page: 758
  year: 2009
  ident: R45-37-20210226
  article-title: Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgn286
– volume: 27
  start-page: 305
  year: 2012
  ident: R74-37-20210226
  article-title: The interleukin-10-1082 promoter polymorphism and cancer risk: a meta-analysis
  publication-title: Mutagenesis
  doi: 10.1093/mutage/ger078
– volume: 13
  start-page: 1547
  year: 2004
  ident: R47-37-20210226
  article-title: Polymorphisms in interleukin -2, -6, and -10 are not associated with gastric cardia or esophageal cancer in a high-risk chinese population
  publication-title: Cancer Epidemiol Biomarkers Prevent
  doi: 10.1158/1055-9965.1547.13.9
– volume: 139
  start-page: 737
  year: 2014
  ident: R48-37-20210226
  article-title: Association of interleukin-10 with hepatitis B virus (HBV) mediated disease progression in Indian population
  publication-title: Indian J Med Res
– volume: 118
  start-page: 649
  year: 2006
  ident: R52-37-20210226
  article-title: Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and -10 genes
  publication-title: Int J Cancer
  doi: 10.1002/ijc.21364
– volume: 5
  start-page: 169
  year: 2005
  ident: R11-37-20210226
  article-title: Association of interleukin-1B and interleukin-1RN polymorphisms with gastric cancer in a high-risk population of Costa Rica
  publication-title: Clin Exp Med
  doi: 10.1007/s10238-005-0082-3
– volume: 102
  start-page: 336
  year: 2011
  ident: R68-37-20210226
  article-title: Interaction of coagulation factors and tumor-associated macrophages mediates migration and invasion of gastric cancer
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2010.01795.x
– volume: 16
  start-page: 9
  year: 2012
  ident: R30-37-20210226
  article-title: Increased risk for gastric cancer in carriers of the lymphotoxin-alpha+252G variant infected by Helicobacter pylori
  publication-title: Genet Test Mol Biomarkers
  doi: 10.1089/gtmb.2011.0078
– volume: 14
  start-page: 1613
  year: 2005
  ident: R41-37-20210226
  article-title: The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland
  publication-title: Cancer Epidemiol Biomarkers Prevent
  doi: 10.1158/1055-9965.EPI-04-0878
– volume: 38
  start-page: 46
  year: 2007
  ident: R58-37-20210226
  article-title: Is IL-10-819C/T gene polymorphism modulating the risk of gallbladder disease in north Indian population?
  publication-title: J Gastrointest Cancer
  doi: 10.1007/s12029-008-9016-0
– volume: 12
  start-page: 183
  year: 2012
  ident: R12-37-20210226
  article-title: Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-12-183
– volume: 34
  start-page: 19
  year: 2003
  ident: R31-37-20210226
  article-title: Frequency and nature of cytokine gene polymorphisms in hepatocellular carcinoma in Hong Kong Chinese
  publication-title: Int J Gastrointest Cancer
  doi: 10.1385/IJGC:34:1:19
– volume: 20
  start-page: 1739
  year: 2009
  ident: R57-37-20210226
  article-title: Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer
  publication-title: Cancer Causes Control
  doi: 10.1007/s10552-009-9427-7
– volume: 14
  start-page: 3443
  year: 2013
  ident: R54-37-20210226
  article-title: Interleukin 10 rs1800872 T>G polymorphism was associated with an increased risk of esophageal cancer in a Chinese population
  publication-title: Asian Pac J Cancer Prev
  doi: 10.7314/APJCP.2013.14.6.3443
– volume: 11
  start-page: e1001713
  year: 2014
  ident: R6-37-20210226
  article-title: Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a mendelian randomization analysis
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.1001713
– volume: 327
  start-page: 557
  year: 2003
  ident: R9-37-20210226
  article-title: Measuring inconsistency in meta-analyses
  publication-title: BMJ
  doi: 10.1136/bmj.327.7414.557
– volume: 157
  start-page: 243
  year: 2012
  ident: R7-37-20210226
  article-title: Association of interleukin-6 circulating levels with coronary artery disease: a meta-analysis implementing mendelian randomization approach
  publication-title: Int J Cardiol
  doi: 10.1016/j.ijcard.2011.12.098
– volume: 4
  start-page: 5335
  year: 2014
  ident: R72-37-20210226
  article-title: The -1082A>G polymorphism in promoter region of interleukin-10 and risk of digestive cancer: a meta-analysis
  publication-title: Sci Rep
  doi: 10.1038/srep05335
– volume: 7
  start-page: 1
  year: 1995
  ident: R70-37-20210226
  article-title: Isolation of the human interleukin 10 promoter. Characterization of the promoter activity in Burkitt's lymphoma cell lines
  publication-title: Cytokine
  doi: 10.1006/cyto.1995.1001
– volume: 139
  start-page: 1008
  year: 2009
  ident: R36-37-20210226
  article-title: Soybean product intake modifies the association between interleukin-10 genetic polymorphisms and gastric cancer risk
  publication-title: J Nutr
  doi: 10.3945/jn.108.101865
– volume: 9
  start-page: 2678
  year: 2003
  ident: R65-37-20210226
  article-title: Persistence of epidermal growth factor receptor and interleukin 10 in blood of colorectal cancer patients after surgery identifies patients with high risk to relapse
  publication-title: Clin Cancer Res
– volume: 15
  start-page: 6961
  year: 2014
  ident: R14-37-20210226
  article-title: Combined effects of six cytokine gene polymorphisms and SNP-SNP interactions on hepatocellular carcinoma risk in Southern Guangxi, China
  publication-title: Asian Pac J Cancer Prev
  doi: 10.7314/APJCP.2014.15.16.6961
– volume: 15
  start-page: 1126
  year: 2006
  ident: R28-37-20210226
  article-title: Inflammation-related gene polymorphisms and colorectal adenoma
  publication-title: Cancer Epidemiol Biomarkers Prev
  doi: 10.1158/1055-9965.EPI-06-0042
– volume: 68
  start-page: 6442
  year: 2008
  ident: R32-37-20210226
  article-title: Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-08-0444
– volume: 347
  start-page: 89
  year: 2011
  ident: R62-37-20210226
  article-title: Interleukin-10-1082 promoter polymorphism and gastric cancer risk in a Chinese Han population
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-010-0616-1
– volume: 29
  start-page: 1572
  year: 2008
  ident: R18-37-20210226
  article-title: Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgn164
– volume: 124
  start-page: 1193
  year: 2003
  ident: R24-37-20210226
  article-title: Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(03)00157-4
– volume: 68
  start-page: 698
  year: 2007
  ident: R19-37-20210226
  article-title: High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer
  publication-title: Hum Immunol
  doi: 10.1016/j.humimm.2007.05.002
– volume: 42
  start-page: 505
  year: 2005
  ident: R42-37-20210226
  article-title: Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection–association between TGF-beta1 polymorphisms and hepatocellular carcinoma
  publication-title: J Hepatol
  doi: 10.1016/j.jhep.2004.11.026
– volume: 32
  start-page: 3938
  year: 2012
  ident: R67-37-20210226
  article-title: Interleukin-10-induced neutrophil gelatinase-associated lipocalin production in macrophages with consequences for tumor growth
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00413-12
– volume: 12
  start-page: 901
  year: 2003
  ident: R51-37-20210226
  article-title: Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddg104
– volume: 362
  start-page: 241
  year: 2012
  ident: R61-37-20210226
  article-title: Diverse H. pylori strains, IL-10 promoter polymorphisms with high morbidity of gastric cancer in Hexi area of Gansu Province, China
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-011-1149-y
– volume: 26
  start-page: 532
  year: 2012
  ident: R16-37-20210226
  article-title: Interleukin-4 receptor -3223T→C polymorphism is associated with increased gastric adenocarcinoma risk
  publication-title: Can J Gastroenterol
  doi: 10.1155/2012/804173
– volume: 143
  start-page: 550
  year: 2012
  ident: R2-37-20210226
  article-title: Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2012.07.009
– volume: 125
  start-page: 2595
  year: 2009
  ident: R13-37-20210226
  article-title: Synergistic effect of HLA class II loci and cytokine gene polymorphisms on the risk of gastric cancer in Japanese patients with Helicobacter pylori infection
  publication-title: Int J Cancer
  doi: 10.1002/ijc.24666
– volume: 380
  start-page: 19
  year: 2014
  ident: R64-37-20210226
  article-title: Control of intestinal inflammation by interleukin-10
  publication-title: Curr Top Microbiol Immunol
– volume: 22
  start-page: 1443
  year: 2007
  ident: R53-37-20210226
  article-title: Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects
  publication-title: J Gastroenterol Hepatol
  doi: 10.1111/j.1440-1746.2006.04613.x
– volume: 102
  start-page: 1878
  year: 2007
  ident: R26-37-20210226
  article-title: Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain
  publication-title: Am J Gastroenterol
  doi: 10.1111/j.1572-0241.2007.01423.x
– volume: 12
  start-page: 95
  year: 2009
  ident: R3-37-20210226
  article-title: Serum interleukin-6 and -10 levels in patients with gastric cancer
  publication-title: Gastric Cancer
  doi: 10.1007/s10120-009-0509-8
– volume: 1155
  start-page: 284
  year: 2009
  ident: R49-37-20210226
  article-title: Genetic determined downregulation of both type 1 and type 2 cytokine pathways might be protective against pancreatic cancer
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2008.03686.x
– volume: 1089
  start-page: 98
  year: 2006
  ident: R20-37-20210226
  article-title: Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma
  publication-title: Ann N Y Acad Sci
  doi: 10.1196/annals.1386.002
– volume: 19
  start-page: 1894
  year: 2008
  ident: R21-37-20210226
  article-title: Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdn400
– volume: 7
  start-page: e29643
  year: 2012
  ident: R35-37-20210226
  article-title: Effects of interleukin-10 polymorphisms, Helicobacter pylori infection, and smoking on the risk of noncardia gastric cancer
  publication-title: PloS One
  doi: 10.1371/journal.pone.0029643
– volume: 53
  start-page: 1934
  year: 2012
  ident: R1-37-20210226
  article-title: Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma
  publication-title: Leuk Lymphoma
  doi: 10.3109/10428194.2012.682307
– volume: 11
  start-page: 41
  year: 2011
  ident: R10-37-20210226
  article-title: Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics
  publication-title: BMC Med Res Methodol
  doi: 10.1186/1471-2288-11-41
– volume: 225
  start-page: 207
  year: 2005
  ident: R37-37-20210226
  article-title: Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in Korea
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2004.11.028
– volume: 14
  start-page: 2577
  year: 2013
  ident: R46-37-20210226
  article-title: Interleukin-10 gene promoter polymorphisms and risk of gastric cancer in a Chinese population: single nucleotide and haplotype analyses
  publication-title: Asian Pac J Cancer Prev
  doi: 10.7314/APJCP.2013.14.4.2577
– volume: 34
  start-page: 3523
  year: 2014
  ident: R27-37-20210226
  article-title: Role of cytokine gene polymorphisms in gastric cancer risk in Chile
  publication-title: Anticancer Res
– volume: 104
  start-page: 617
  year: 2003
  ident: R59-37-20210226
  article-title: Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese
  publication-title: Int J Cancer
  doi: 10.1002/ijc.10987
– volume: 75
  start-page: 711
  year: 2003
  ident: R4-37-20210226
  article-title: Interindividual variations in constitutive interleukin-10 messenger RNA and protein levels and their association with genetic polymorphisms
  publication-title: Transplantation
  doi: 10.1097/01.TP.0000055216.19866.9A
– volume: 29
  start-page: 141
  year: 2005
  ident: R60-37-20210226
  article-title: Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2004.10.013
– volume: 67
  start-page: 127
  year: 2006
  ident: R56-37-20210226
  article-title: Correlation of interleukin-10 gene haplotype with hepatocellular carcinoma in Taiwan
  publication-title: Tissue Antigens
  doi: 10.1111/j.1399-0039.2006.00536.x
– volume: 17
  start-page: 1362
  year: 2011
  ident: R39-37-20210226
  article-title: Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v17.i10.1362
– volume: 4
  start-page: 1103
  year: 2006
  ident: R43-37-20210226
  article-title: Gastric cancer and the high combination prevalence of host cytokine genotypes and Helicobacter pylori in Honduras
  publication-title: Clin Gastroenterol Hepatol
  doi: 10.1016/j.cgh.2006.05.025
– volume: 59
  start-page: 773
  year: 2013
  ident: R17-37-20210226
  article-title: Cytokine promoter polymorphisms and risk of colorectal cancer
  publication-title: Clin Lab
  doi: 10.7754/Clin.Lab.2012.120713
– volume: 35
  start-page: 362
  year: 2011
  ident: R38-37-20210226
  article-title: Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population
  publication-title: Cancer Epidemiol
  doi: 10.1016/j.canep.2011.01.005
SSID ssj0013724
Score 2.2138934
SecondaryResourceType review_article
Snippet Recent studies have observed a high level of circulating interleukin-10 (IL-10) in patients with digestive cancers, yet whether elevated IL-10 is causally...
Supplemental Digital Content is available in the text Recent studies have observed a high level of circulating interleukin-10 (IL-10) in patients with...
SourceID pubmedcentral
proquest
pubmed
crossref
wolterskluwer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage e2799
SubjectTerms Digestive System Neoplasms - blood
Digestive System Neoplasms - genetics
Humans
Interleukin-10 - blood
Interleukin-10 - genetics
Mendelian Randomization Analysis
Regression Analysis
Systematic Reviewand Meta-Analysis
Title A Causal Role of Genetically Elevated Circulating Interleukin-10 in the Development of Digestive Cancers: Evidence from Mendelian Randomization Analysis Based on 29,307 Subjects
URI https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005792-201602150-00037
https://www.ncbi.nlm.nih.gov/pubmed/26886630
https://www.proquest.com/docview/1767072560
https://pubmed.ncbi.nlm.nih.gov/PMC4998630
Volume 95
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgkxASQtzpgMlIvI1A6zhx_FjaogmpA6QOJl4ix3HUaFXK1obbr8fHlzRZp4nRh6hKHCvJ-XJy7PP5Owi9CjNaSJbxQA9-RECFiALOKQ9UTpNMShZayfzpUXx4TD-cRCebdIFZXbLO3sg_l64r-R-r6n3arrBK9hqWbTrVO_R_bV-91RbW23-y8fBgJOoVyOM7jiCISJvJ6cXvg8lC_RAQT47Kc2mKdBluADA4VX1aVto1epJjizkEvdikE1CKRoAJl-_xZZ9cMh5C03disS4tU7eZTzgqa8PbU9VZvUHeJzct_dl_KYEDZOULZq1dX12zb_Pyl5MEdzMSg4bEvPGyUCKX2-o73svaUpoOTazlMhVhtkTSljO3IsHTsdWYdD_fuiudfeGT1hANfYp9Ok4vdnIT7RI9tNC-cffjl8lkvMk9MUKbQr_6LrxWFWdvL7mWbjyzNUjZ5tre-bkEHsTq1CyDaAUzs3vorhuF4KGF1H10Q1UP0C1v2odoPsQWWRiQhZcFbiELe2ThFrJwF1m4rLBGFm4hC3ppkIUdsh6h4_eT2egwcDU5AgmhfRCpnGd5pmhBYtB6JEVO-jyROYvzgQjDTPZDUWQsktwoOfWTXN97RmNVREzqF_8x2qmWlXqKMAtjHSwTGiqW0DDsc1EoyomURCRRTIseIv7JptIJ1kPdlEV6hVV76HVz0ner13J185feZKn2q5AsE5Va1qt0wGLWZzAg6KEn1oRNhyROEh2p6yOsY9ymAWi2d49U5dxot1POE3Nm0IFBalc9m-uLGCcBvFcQjhvZh5DtXe-2nqHbmxfzOdpZn9fqhQ6e19m-mXTad5j_CxaTvHI
linkProvider Ovid
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bb9MwFLZgkwAJIa6jXI2E-rSM1HHiGKkPpc0oYylo7WB7ihLHgWolmZp2iJ_FP-QcJyktE0jkJVHs-CE-Pv58Lt8h5KWT8EyJRFpw-IktHseuJSWXlk65nyglnIoyPxx5w2N-cOKe1NEWmAuD2Wfl-R7ejJ7GB6yHgwfDSfdg3B4Fn8fdvN0f97un7Y-9t4GxU2OURHvQLS6yRbs3MvFXrpAMZKDj4a5msqcdcZVsey4TsIC3P3wKgsFvf4NgfFXcFSB2w08kxatwUHEc1hcThiZ2bQ-7BEwvx1fe_F6g77s8M6HvaxvY_m1yq0aetFeJyh1yRed3ybWw9q3fIz97tB8vS-hyVMw0LTKKlNTG1D37QYOZvgBYmtL-dK5Mya_8CzXmxJlenk1zULR0mlOAk3QtDglHqVxYoFRheJCwefmaNqVMKSa30BCt8GhtoUdxnhbf6sxQ2vCl0Dew06YU3jC5C8qCgrJD61F5nxzvB5P-0KoLOlgKcaHl6lQmaaJ5xjwkCmRZymzpq1R4aSd2nETZTpwlwlXS0ADZfgo_MeGezlyhQGoekK28yPVDQoXjAdJi3NHC545jyzjTXDKlWOy7Hs9ahDVTFKma7RyLbsyixuseDqI_57VFdlcfnVdkH__u_qKZ-wgWJXpa4lwXyzLqCE_YAtFki-xUsrAakHm-DzAPWsSGlKw6IOH3Zks-_WqIv-F06psvrQ15iqqU2ehvUv_oP_s_J9eHk_AwOnw3ev-Y3MDWKk79CdlazJf6KcCwRfKsXkO_AMXYJzc
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bb9MwFLZGJ01ICDGu5TYjoTwtKLWdOEbKQ2lSxqDdtG5jPEWJ40C1kkxNO7SfxT_k2EnKyhASeUkUXxTFx8efzzn-DkKvacpyyVNhw-YnsVmSuLYQTNgqY34qJac1Zf5o7O2dsP0z92wDtR5Tffisunijb0ZN6wedDkfvC4-D_Yk1mAyCL9Y4-jwJxtZh_31kzNQ6SMI6DIfBlRUG5WW-sMKDoOVnHIU1SWFzES7ELbTp-wDkO2jz4DSKwt9-B07YKskrQO2Wp-jv3ayvZTcA6s04yzs_Su0Dr85NCPy1hWx4D91tECju1yKzjTZUcR9tjRof-wP0s48HybKCKkflTOEyx5qa2pi8Z1c4mqlLgKcZHkzn0qT-Kr5iY1acqeX5tACFi6cFBliJr8Uj6V5qVxYoV-geJG1evcVtSlOsD7ngkbbGa6sLPkqKrPzenBDFLW8KfgcrbobhDRG7oDQwKD1tRaoeopNhdDzYs5vEDrbU-NB2VSbSLFUsJ54mDCR5Rhzhy4x7WS-hNJUOTfKUu1IYOiDHz-AnpsxTucslSM8j1CnKQj1BmFMPEBdhVHGfUeqIJFdMEClJ4rsey7uItEMUy4b1XCffmMWt930Uxn-Oaxftrhpd1KQf_67-qh37GCan9rgkhSqXVdzjHne4RpVd9LiWhVWHxAMR9CiU8DUpWVXQxN_rJcX0myEAh12qb1raa_IU10dnzfe5XBDQgD1PYzrDHUD50_-sv4O2YE7Fnz6MPz5Dt3VhHa7-HHUW86V6AWhskb5sptAvdhMozQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Causal+Role+of+Genetically+Elevated+Circulating+Interleukin-10+in+the+Development+of+Digestive+Cancers&rft.jtitle=Medicine+%28Baltimore%29&rft.au=Niu%2C+Wenquan&rft.au=Pang%2C+Qing&rft.au=Lin%2C+Ting&rft.au=Wang%2C+Zhixin&rft.date=2016-02-01&rft.issn=0025-7974&rft.volume=95&rft.issue=7&rft.spage=e2799&rft_id=info:doi/10.1097%2FMD.0000000000002799&rft.externalDBID=n%2Fa&rft.externalDocID=10_1097_MD_0000000000002799
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0025-7974&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0025-7974&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0025-7974&client=summon