A single mutation in one of the CORE elements of Moloney murine leukemia virus reduced binding of a 42-kDa T lymphoma cell nuclear factor but did not affect lymphomagenesis

• Published in: Molecular carcinogenesis Vol. 3; no. 2; p. 93
• Main Authors: Case, R S, Khang, Y H, Kumar, A, Yuen, P H
• Format: Journal Article
• Language: English
• Published: United States 1990
• Subjects: Animals; Base Sequence; Cell Transformation, Viral; Cloning, Molecular; DNA Probes; DNA, Viral - analysis; Enhancer Elements, Genetic; Lymphoma - genetics; Lymphoma - pathology; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Moloney murine leukemia virus - genetics; Mutation; Nuclear Proteins - genetics; T-Lymphocytes - metabolism; Tumor Cells, Cultured

The genetic determinant responsible for virulence in Moloney murine leukemia virus (MoMuLV) induced T-cell lymphomagenesis has recently been mapped [J Virol 63:471-480, 1989] by homologous genomic fragment exchange between MoMuLV and MoMuLV-TB to the Clal/Xbal at the 3' end of the genome. This...