Manganese superoxide dismutase activity and incidence of hepatocellular carcinoma in patients with Child-Pugh class A liver cirrhosis: a 7-year follow-up study

• Published in: Liver international Vol. 27; no. 6; pp. 791 - 797
• Main Authors: Clemente, Caterina, Elba, Silvana, Buongiorno, Gianpiero, Guerra, Vito, D'Attoma, Benedetta, Orlando, Antonella, Russo, Francesco
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2007
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - blood; Carcinoma, Hepatocellular - enzymology; Carcinoma, Hepatocellular - epidemiology; Carcinoma, Hepatocellular - etiology; Carcinoma, Hepatocellular - pathology; Case-Control Studies; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Female; Follow-Up Studies; hepatocellular carcinoma; Humans; Incidence; liver cirrhosis; Liver Cirrhosis - complications; Liver Cirrhosis - enzymology; Liver Cirrhosis - epidemiology; Liver Cirrhosis - pathology; Liver Neoplasms - enzymology; Liver Neoplasms - epidemiology; Liver Neoplasms - etiology; Liver Neoplasms - pathology; Male; manganese superoxide dismutase; Middle Aged; Proportional Hazards Models; Reproducibility of Results; Risk Assessment; Risk Factors; ROC Curve; Severity of Illness Index; Superoxide Dismutase - blood; Time Factors

Aims: To evaluate possible modifications in the manganese superoxide dismutase (MnSOD) activity during neoplastic transformation of a cirrhotic liver and to find out whether its assessment may have predictive value to identify cirrhotic patients at a higher risk of hepatocellular carcinoma (HCC). Me...