Successful acute lymphoblastic leukemia‐type therapy in two children with mixed‐phenotype acute leukemia

• Published in: Pediatrics international Vol. 58; no. 10; pp. 1072 - 1076
• Main Authors: Otsubo, Keisuke, Yabe, Miharu, Yabe, Hiromasa, Fukumura, Akiko, Morimoto, Tsuyoshi, Kato, Masahiko, Mochizuki, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.10.2016
• Subjects: 2008 World Health Organization classification; Acute Disease; Acute lymphoblastic leukemia; acute lymphoblastic leukemia‐type therapy; acute myeloblastic leukemia‐type therapy; Biopsy; Bone Marrow Cells - pathology; CD3 antigen; Child; Children; Classification; Combined Modality Therapy - methods; Female; Genotype & phenotype; Humans; Immunology; Leukemia; Lymphatic leukemia; Male; mixed phenotype; Patients; Pediatrics; Peroxidase; Phenotypes; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy; Remission; Stem cell transplantation; Transplantation; Treatment Outcome; 2008 World Health Organization classification; mixed phenotype; acute myeloblastic leukemia-type therapy; acute lymphoblastic leukemia-type therapy

Mixed‐phenotype acute leukemia (MPAL) is a rare type of leukemia expressing both myeloid and lymphoid markers. There is limited information, especially on pediatric cases. Therefore, the optimal therapeutic approach to pediatric MPAL has not been defined. Here, we report two pediatric cases of MPAL....