Efficacy and safety of adjunctive corticosteroids therapy for patients with severe community-acquired pneumonia: A systematic review and meta-analysis

• Published in: Medicine (Baltimore) Vol. 98; no. 13; p. e14636
• Main Authors: Huang, Jing, Guo, Jiquan, Li, Hongtao, Huang, Weibin, Zhang, Tiantuo
• Format: Journal Article
• Language: English
• Published: United States the Author(s). Published by Wolters Kluwer Health, Inc 01.03.2019; Wolters Kluwer Health
• Subjects: Adrenal Cortex Hormones - administration & dosage; Adrenal Cortex Hormones - adverse effects; Adrenal Cortex Hormones - therapeutic use; Adult; Aged; Community-Acquired Infections - drug therapy; Community-Acquired Infections - epidemiology; Humans; Hydrocortisone - administration & dosage; Hydrocortisone - adverse effects; Hydrocortisone - therapeutic use; Intensive Care Units; Length of Stay - statistics & numerical data; Methylprednisolone - administration & dosage; Methylprednisolone - adverse effects; Methylprednisolone - therapeutic use; Middle Aged; Mortality - trends; Pneumonia - drug therapy; Pneumonia - mortality; Prednisolone - administration & dosage; Prednisolone - adverse effects; Prednisolone - therapeutic use; Randomized Controlled Trials as Topic; Respiration, Artificial - statistics & numerical data; Severity of Illness Index; Systematic Review and Meta-Analysis; Treatment Outcome

The systemic use of corticosteroids for patients in severe community-acquired pneumonia (CAP) remains disputed in clinical practice. We undertook a systematic review and meta-analysis to assess the efficacy and safety of corticosteroids in patients with severe CAP. We searched MEDLINE (1946 to June...