Prognostic significance of tumor-associated macrophages in patients with nasopharyngeal carcinoma: A meta-analysis

To explore the prognostic value of diverse subsets of tumor-associated macrophages (TAMs) in prognosis in patients with nasopharyngeal carcinoma (NPC) using meta-analysis. Relevant studies were searched in the database of PubMed, Web of Science, Embase, Cochrane Library, Scopus, China National Knowl...

Full description

Saved in:
Bibliographic Details
Published inMedicine (Baltimore) Vol. 99; no. 39; p. e21999
Main Author Chen, Ya-Lian
Format Journal Article
LanguageEnglish
Published United States Lippincott Williams & Wilkins 25.09.2020
Subjects
Adult
Aged
Biomarkers, Tumor - metabolism
Disease-Free Survival
Female
Humans
Macrophages - metabolism
Male
Middle Aged
Nasopharyngeal Carcinoma - mortality
Nasopharyngeal Neoplasms - mortality
Systematic Review and Meta-Analysis
Young Adult
Online AccessGet full text

Cover

Abstract To explore the prognostic value of diverse subsets of tumor-associated macrophages (TAMs) in prognosis in patients with nasopharyngeal carcinoma (NPC) using meta-analysis. Relevant studies were searched in the database of PubMed, Web of Science, Embase, Cochrane Library, Scopus, China National Knowledge Infrastructure (CNKI), and Wanfang till November 2019. The relationship between TAMs and survival outcomes was estimated by pooling hazard ratios (HRs) and 95% confidence intervals (CIs); and the correlation of TAMs and clinicopathological factors was evaluated by using odds ratios (ORs) and 95%CIs. Six studies with 1549 patients were included in this meta-analysis. The high expression of CD68+ TAMs was associated with favorable disease-free survival (DFS) (HR = 0.66, 95%CI = 0.50-0.88, P = .005), whereas the density of M2-like TAMs (CD163+, CD68+CCL18+, and CD206+) was correlated to poor overall survival (OS) (HR = 1.77, 95%CI = 1.22-2.56, P = .003) and DFS (HR = 1.96, 95%CI = 1.00-3.85, P = .050) in patients with NPC. CD68+ TAM density is associated with superior DFS, while CD163+ M2-like TAMs predicted poor prognosis in patients with NPC.
AbstractList To explore the prognostic value of diverse subsets of tumor-associated macrophages (TAMs) in prognosis in patients with nasopharyngeal carcinoma (NPC) using meta-analysis.BACKGROUNDTo explore the prognostic value of diverse subsets of tumor-associated macrophages (TAMs) in prognosis in patients with nasopharyngeal carcinoma (NPC) using meta-analysis.Relevant studies were searched in the database of PubMed, Web of Science, Embase, Cochrane Library, Scopus, China National Knowledge Infrastructure (CNKI), and Wanfang till November 2019. The relationship between TAMs and survival outcomes was estimated by pooling hazard ratios (HRs) and 95% confidence intervals (CIs); and the correlation of TAMs and clinicopathological factors was evaluated by using odds ratios (ORs) and 95%CIs.METHODSRelevant studies were searched in the database of PubMed, Web of Science, Embase, Cochrane Library, Scopus, China National Knowledge Infrastructure (CNKI), and Wanfang till November 2019. The relationship between TAMs and survival outcomes was estimated by pooling hazard ratios (HRs) and 95% confidence intervals (CIs); and the correlation of TAMs and clinicopathological factors was evaluated by using odds ratios (ORs) and 95%CIs.Six studies with 1549 patients were included in this meta-analysis. The high expression of CD68+ TAMs was associated with favorable disease-free survival (DFS) (HR = 0.66, 95%CI = 0.50-0.88, P = .005), whereas the density of M2-like TAMs (CD163+, CD68+CCL18+, and CD206+) was correlated to poor overall survival (OS) (HR = 1.77, 95%CI = 1.22-2.56, P = .003) and DFS (HR = 1.96, 95%CI = 1.00-3.85, P = .050) in patients with NPC.RESULTSSix studies with 1549 patients were included in this meta-analysis. The high expression of CD68+ TAMs was associated with favorable disease-free survival (DFS) (HR = 0.66, 95%CI = 0.50-0.88, P = .005), whereas the density of M2-like TAMs (CD163+, CD68+CCL18+, and CD206+) was correlated to poor overall survival (OS) (HR = 1.77, 95%CI = 1.22-2.56, P = .003) and DFS (HR = 1.96, 95%CI = 1.00-3.85, P = .050) in patients with NPC.CD68+ TAM density is associated with superior DFS, while CD163+ M2-like TAMs predicted poor prognosis in patients with NPC.CONCLUSIONSCD68+ TAM density is associated with superior DFS, while CD163+ M2-like TAMs predicted poor prognosis in patients with NPC.
To explore the prognostic value of diverse subsets of tumor-associated macrophages (TAMs) in prognosis in patients with nasopharyngeal carcinoma (NPC) using meta-analysis. Relevant studies were searched in the database of PubMed, Web of Science, Embase, Cochrane Library, Scopus, China National Knowledge Infrastructure (CNKI), and Wanfang till November 2019. The relationship between TAMs and survival outcomes was estimated by pooling hazard ratios (HRs) and 95% confidence intervals (CIs); and the correlation of TAMs and clinicopathological factors was evaluated by using odds ratios (ORs) and 95%CIs. Six studies with 1549 patients were included in this meta-analysis. The high expression of CD68+ TAMs was associated with favorable disease-free survival (DFS) (HR = 0.66, 95%CI = 0.50-0.88, P = .005), whereas the density of M2-like TAMs (CD163+, CD68+CCL18+, and CD206+) was correlated to poor overall survival (OS) (HR = 1.77, 95%CI = 1.22-2.56, P = .003) and DFS (HR = 1.96, 95%CI = 1.00-3.85, P = .050) in patients with NPC. CD68+ TAM density is associated with superior DFS, while CD163+ M2-like TAMs predicted poor prognosis in patients with NPC.
Author Chen, Ya-Lian
AuthorAffiliation Department of Otolaryngology, Shengzhou People's Hospital, (The First Affiliated Hospital of Zhejiang University Shengzhou Branch), Zhejiang, China
AuthorAffiliation_xml – name: Department of Otolaryngology, Shengzhou People's Hospital, (The First Affiliated Hospital of Zhejiang University Shengzhou Branch), Zhejiang, China
Author_xml – sequence: 1
  givenname: Ya-Lian
  surname: Chen
  fullname: Chen, Ya-Lian
  organization: Department of Otolaryngology, Shengzhou People's Hospital, (The First Affiliated Hospital of Zhejiang University Shengzhou Branch), Zhejiang, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32991403$$D View this record in MEDLINE/PubMed
BookMark eNqFUU1v1TAQtFARfS38AiTkI5cU24njmANS1fIltYIDnK2NYyeGxH7YDk_99_j1lQK94Iul3Znd2ZkTdOSDNwg9p-SMEileXV-ekT-PUSnlI7ShvG4rLtvmCG1KlVdCiuYYnaT0jRBaC9Y8Qcc1k5I2pN6g-DmG0YeUncbJjd5Zp8Frg4PFeV1CrCCloB1kM-AFdAzbCUaTsPN4C9kZnxPeuTxhD2nfizd-NDBjDVE7HxZ4jc_xYjJU4GG-SS49RY8tzMk8u_tP0dd3b79cfKiuPr3_eHF-VemGcF4xM9CusQP0fd_ZnlJNOZChp42QtW3NIIyAbhiErS20mhHLgAhNKS-3db2sT9Gbw9zt2i9m0EVqhFlto1uKShXAqX873k1qDD-V4KwWkpYBL-8GxPBjNSmrxSVt5hm8CWtSrGkE56xreYG--HvX_ZLfRhdAfQAUB1OKxt5DKFH7ONX1pXoYZ2HJByztcnE97AW7-T_c5sDdhTmbmL7P685ENZVw8nQL50KyihFGiGScVLel-hf09LcX
CitedBy_id crossref_primary_10_1096_fj_202201628RR
crossref_primary_10_3389_fonc_2021_744889
crossref_primary_10_1186_s12885_021_08675_x
crossref_primary_10_3389_fimmu_2023_1193235
crossref_primary_10_3389_bjbs_2023_11065
crossref_primary_10_3390_diagnostics14232648
crossref_primary_10_3390_biomedicines12102306
crossref_primary_10_3389_fonc_2022_840467
crossref_primary_10_3390_genes15020197
crossref_primary_10_1016_j_gendis_2021_07_002
crossref_primary_10_3390_cancers15194850
crossref_primary_10_3390_ijms21239328
crossref_primary_10_1038_s41568_022_00546_2
crossref_primary_10_3390_cancers13205189
Cites_doi 10.2217/imt-2018-0006
10.1111/sji.12814
10.1080/00016489.2017.1296585
10.1259/bjr.20190209
10.1038/nrclinonc.2016.217
10.1158/0008-5472.CAN-16-2706
10.1016/S0140-6736(19)30956-0
10.2147/CMAR.S196951
10.1002/jcb.27646
10.3322/caac.21492
10.1186/1745-6215-8-16
10.21037/cco.2016.03.08
10.2147/CMAR.S167071
10.1016/j.ygyno.2018.01.014
10.1038/s41577-019-0127-6
10.1371/journal.pone.0170042
10.18632/oncotarget.15736
10.1172/JCI59643
10.18632/oncotarget.25334
10.1111/jop.12643
10.1111/j.1600-065X.2008.00607.x
10.1016/j.oraloncology.2019.04.019
10.1371/journal.pone.0223971
10.18632/oncotarget.9079
10.1159/000486816
10.1158/1055-9965.EPI-06-0353
10.1371/journal.pone.0050946
10.1007/s11033-020-05334-5
10.1016/j.genrep.2020.100706
10.1007/s10654-010-9491-z
10.1186/s43046-019-0005-0
10.1159/000364945
10.1016/j.jclinepi.2009.06.005
10.2217/fon-2018-0669
10.1038/srep37874
ContentType Journal Article
Copyright Lippincott Williams & Wilkins
Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020
Copyright_xml – notice: Lippincott Williams & Wilkins
– notice: Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1097/MD.0000000000021999
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1536-5964
EndPage e21999
ExternalDocumentID PMC7523791
32991403
10_1097_MD_0000000000021999
00005792-202009250-00005
Genre Meta-Analysis
Systematic Review
Journal Article
GroupedDBID ---
.-D
.XZ
.Z2
01R
0R~
354
40H
4Q1
4Q2
4Q3
5GY
5RE
5VS
71W
77Y
7O~
AAAAV
AAGIX
AAHPQ
AAIQE
AAMOA
AAQKA
AARTV
AASCR
AAWTL
AAXQO
AAYEP
ABASU
ABBUW
ABCQX
ABDIG
ABFRF
ABOCM
ABVCZ
ABXVJ
ABZAD
ABZZY
ACDDN
ACEWG
ACGFO
ACGFS
ACILI
ACLDA
ACWDW
ACWRI
ACXJB
ACXNZ
ACZKN
ADGGA
ADHPY
ADNKB
ADPDF
AE6
AEFWE
AENEX
AFBFQ
AFDTB
AGOPY
AHOMT
AHQNM
AHVBC
AIJEX
AINUH
AJCLO
AJIOK
AJNWD
AJNYG
AJZMW
AKCTQ
AKULP
ALKUP
ALMA_UNASSIGNED_HOLDINGS
ALMTX
AMJPA
AMKUR
AMNEI
AOHHW
AOQMC
BQLVK
CS3
DIWNM
DU5
E.X
EBS
EEVPB
ERAAH
EX3
F2K
F2L
F2M
F2N
F5P
FCALG
FD6
FIJ
FL-
GNXGY
GQDEL
GROUPED_DOAJ
H0~
HLJTE
HYE
HZ~
H~9
IKREB
IKYAY
IN~
IPNFZ
JK3
JK8
K8S
KD2
KMI
KQ8
L-C
N9A
N~7
N~B
O9-
OAG
OAH
OB2
OHH
OK1
OL1
OLB
OLG
OLH
OLU
OLV
OLY
OLZ
OPUJH
OUVQU
OVD
OVDNE
OVEED
OVIDH
OVLEI
OWV
OWW
OWZ
OXXIT
P2P
RIG
RLZ
RPM
RXW
S4R
S4S
TAF
TEORI
TSPGW
UNMZH
V2I
VVN
W3M
WOQ
WOW
X3V
X3W
XYM
YFH
YOC
ZFV
ZY1
AAYXX
CITATION
8L-
ACIJW
AWKKM
CGR
CUY
CVF
ECM
EIF
NPM
ODA
7X8
5PM
ADSXY
ID FETCH-LOGICAL-c4055-2ed184fdabbb8fb11c15a0db14793f6ed7e7a8dd7f3fa6c20f2a07c1159918b93
ISSN 0025-7974
1536-5964
IngestDate Thu Aug 21 18:03:00 EDT 2025
Thu Jul 10 23:45:32 EDT 2025
Wed Feb 19 02:29:17 EST 2025
Thu Apr 24 23:08:13 EDT 2025
Tue Jul 01 03:29:59 EDT 2025
Fri May 16 03:50:24 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 39
Language English
License http://creativecommons.org/licenses/by-nc/4.0
This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c4055-2ed184fdabbb8fb11c15a0db14793f6ed7e7a8dd7f3fa6c20f2a07c1159918b93
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
ORCID 0000-0003-1907-8193
OpenAccessLink http://dx.doi.org/10.1097/MD.0000000000021999
PMID 32991403
PQID 2447552865
PQPubID 23479
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7523791
proquest_miscellaneous_2447552865
pubmed_primary_32991403
crossref_primary_10_1097_MD_0000000000021999
crossref_citationtrail_10_1097_MD_0000000000021999
wolterskluwer_health_00005792-202009250-00005
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20200925
2020-09-25
2020-Sep-25
PublicationDateYYYYMMDD 2020-09-25
PublicationDate_xml – month: 09
  year: 2020
  text: 20200925
  day: 25
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Hagerstown, MD
PublicationTitle Medicine (Baltimore)
PublicationTitleAlternate Medicine (Baltimore)
PublicationYear 2020
Publisher Lippincott Williams & Wilkins
Publisher_xml – name: Lippincott Williams & Wilkins
References Alves (R36-20230915) 2018; 47
Zhang (R32-20230915) 2019
Wu (R40-20230915) 2018; 9
Sun (R3-20230915) 2019; 92
Bray (R1-20230915) 2018; 68
Tamura (R13-20230915) 2018; 10
Huang (R19-20230915) 2017; 137
Abdel Ghafar (R6-20230915) 2020; 47
Zhang (R31-20230915) 2012; 7
Moher (R22-20230915) 2009; 62
Xu (R33-20230915) 2020; 91
Pignatelli (R30-20230915) 2016; 6
He (R16-20230915) 1999
Stang (R24-20230915) 2010; 25
El-Guindy (R8-20230915) 2019; 31
Sica (R11-20230915) 2012; 122
DeNardo (R25-20230915) 2019; 19
Najafi (R28-20230915) 2019; 120
Chen (R4-20230915) 2019; 394
Ding (R27-20230915) 2019; 14
Yu (R38-20230915) 2019; 11
Mantovani (R15-20230915) 2017; 14
Jain (R5-20230915) 2016; 5
Lissbrant (R26-20230915) 2000; 17
Allavena (R9-20230915) 2008; 222
Cai (R17-20230915) 2016; 44
Li (R39-20230915) 2019; 15
Troiano (R34-20230915) 2019; 93
Yin (R35-20230915) 2017; 12
Mei (R37-20230915) 2016; 7
Zhong (R14-20230915) 2018; 45
Yu (R21-20230915) 2018; 10
Krishnan (R29-20230915) 2018; 149
Tierney (R23-20230915) 2007; 8
Zhao (R10-20230915) 2017; 8
Ghafar (R7-20230915) 2020; 20
Xia (R20-20230915) 2017; 17
Huang (R18-20230915) 2017; 77
Mills (R12-20230915) 2014; 6
Chang (R2-20230915) 2006; 15
References_xml – volume: 10
  start-page: 899
  year: 2018
  ident: R13-20230915
  article-title: Dual role of macrophage in tumor immunity
  publication-title: Immunotherapy
  doi: 10.2217/imt-2018-0006
– volume: 91
  start-page: e12814
  year: 2020
  ident: R33-20230915
  article-title: The prognostic value of tumor-associated macrophages in Non-Hodgkin's Lymphoma: a systematic review and meta-analysis
  publication-title: Scand J Immunol
  doi: 10.1111/sji.12814
– volume: 137
  start-page: 888
  year: 2017
  ident: R19-20230915
  article-title: M2-polarized tumour-associated macrophages in stroma correlate with poor prognosis and Epstein-Barr viral infection in nasopharyngeal carcinoma
  publication-title: Acta Otolaryngol
  doi: 10.1080/00016489.2017.1296585
– volume: 17
  start-page: 445
  year: 2000
  ident: R26-20230915
  article-title: Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survival
  publication-title: Int J Oncol
– volume: 92
  start-page: 20190209
  year: 2019
  ident: R3-20230915
  article-title: Future of radiotherapy in nasopharyngeal carcinoma
  publication-title: Br J Radiol
  doi: 10.1259/bjr.20190209
– volume: 14
  start-page: 399
  year: 2017
  ident: R15-20230915
  article-title: Tumour-associated macrophages as treatment targets in oncology
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/nrclinonc.2016.217
– volume: 77
  start-page: 3591
  year: 2017
  ident: R18-20230915
  article-title: Epstein-Barr Virus-induced VEGF and GM-CSF drive nasopharyngeal carcinoma metastasis via recruitment and activation of macrophages
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-16-2706
– volume: 394
  start-page: 64
  year: 2019
  ident: R4-20230915
  article-title: Nasopharyngeal carcinoma
  publication-title: Lancet
  doi: 10.1016/S0140-6736(19)30956-0
– volume: 11
  start-page: 4141
  year: 2019
  ident: R38-20230915
  article-title: Prognostic value of tumor-associated macrophages in pancreatic cancer: a meta-analysis
  publication-title: Cancer Manag Res
  doi: 10.2147/CMAR.S196951
– volume: 120
  start-page: 2756
  year: 2019
  ident: R28-20230915
  article-title: Macrophage polarity in cancer: a review
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.27646
– volume: 68
  start-page: 394
  year: 2018
  ident: R1-20230915
  article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21492
– start-page: 34
  year: 1999
  ident: R16-20230915
  article-title: Immunocyte reaction in stage III nasopharyngeal carcinoma in relation to biological findings and prognosis
  publication-title: Chin J Pathol
– volume: 8
  start-page: 16
  year: 2007
  ident: R23-20230915
  article-title: Practical methods for incorporating summary time-to-event data into meta-analysis
  publication-title: Trials
  doi: 10.1186/1745-6215-8-16
– volume: 5
  start-page: 22
  year: 2016
  ident: R5-20230915
  article-title: Immunotherapy for nasopharyngeal cancer-a review
  publication-title: Chin Clin Oncol
  doi: 10.21037/cco.2016.03.08
– volume: 10
  start-page: 1935
  year: 2018
  ident: R21-20230915
  article-title: The prognostic significance of carcinoma-associated fibroblasts and tumor-associated macrophages in nasopharyngeal carcinoma
  publication-title: Cancer Manag Res
  doi: 10.2147/CMAR.S167071
– volume: 17
  start-page: 333
  year: 2017
  ident: R20-20230915
  article-title: Tumor-associated macrophages promote invasion and metastasis of nasopharyngeal carcinoma
  publication-title: J Trop Med
– volume: 149
  start-page: 205
  year: 2018
  ident: R29-20230915
  article-title: Tumor associated macrophages in gynecologic cancers
  publication-title: Gynecol Oncol
  doi: 10.1016/j.ygyno.2018.01.014
– volume: 19
  start-page: 369
  year: 2019
  ident: R25-20230915
  article-title: Macrophages as regulators of tumour immunity and immunotherapy
  publication-title: Nat Rev Immunol
  doi: 10.1038/s41577-019-0127-6
– volume: 12
  start-page: e0170042
  year: 2017
  ident: R35-20230915
  article-title: The prognostic and clinicopathological significance of tumor-associated macrophages in patients with gastric cancer: a meta-analysis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0170042
– volume: 44
  start-page: 258
  year: 2016
  ident: R17-20230915
  article-title: Influence of CD68+ macrophages in different parts in the tumor microenvironment on progression and prognosis of nasopharyngeal carcinoma
  publication-title: Med Sci J Central South China
– volume: 8
  start-page: 30576
  year: 2017
  ident: R10-20230915
  article-title: Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.15736
– volume: 122
  start-page: 787
  year: 2012
  ident: R11-20230915
  article-title: Macrophage plasticity and polarization: in vivo veritas
  publication-title: J Clin Invest
  doi: 10.1172/JCI59643
– volume: 9
  start-page: 25294
  year: 2018
  ident: R40-20230915
  article-title: Prognostic roles of tumor associated macrophages in bladder cancer: a system review and meta-analysis
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.25334
– volume: 47
  start-page: 460
  year: 2018
  ident: R36-20230915
  article-title: Macrophages and prognosis of oral squamous cell carcinoma: a systematic review
  publication-title: J Oral Pathol Med
  doi: 10.1111/jop.12643
– volume: 222
  start-page: 155
  year: 2008
  ident: R9-20230915
  article-title: The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance
  publication-title: Immunol Rev
  doi: 10.1111/j.1600-065X.2008.00607.x
– volume: 93
  start-page: 66
  year: 2019
  ident: R34-20230915
  article-title: Prognostic significance of CD68(+) and CD163(+) tumor associated macrophages in head and neck squamous cell carcinoma: a systematic review and meta-analysis
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2019.04.019
– volume: 14
  start-page: e0223971
  year: 2019
  ident: R27-20230915
  article-title: Clinicopathologic and prognostic significance of tumor-associated macrophages in patients with hepatocellular carcinoma: a meta-analysis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0223971
– volume: 7
  start-page: 34217
  year: 2016
  ident: R37-20230915
  article-title: Prognostic impact of tumor-associated macrophage infiltration in non-small cell lung cancer: a systemic review and meta-analysis
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.9079
– volume: 45
  start-page: 356
  year: 2018
  ident: R14-20230915
  article-title: The role of tumor-associated macrophages in colorectal carcinoma progression
  publication-title: Cell Physiol Biochem
  doi: 10.1159/000486816
– volume: 15
  start-page: 1765
  year: 2006
  ident: R2-20230915
  article-title: The enigmatic epidemiology of nasopharyngeal carcinoma
  publication-title: Cancer Epidemiol Biomarkers Prev
  doi: 10.1158/1055-9965.EPI-06-0353
– start-page: 1
  year: 2019
  ident: R32-20230915
  article-title: Meta-analysis of the prognostic and clinical value of tumor-associated macrophages in hepatocellular carcinoma
  publication-title: J Investig Surg
– volume: 7
  start-page: e50946
  year: 2012
  ident: R31-20230915
  article-title: Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0050946
– volume: 47
  start-page: 2509
  year: 2020
  ident: R6-20230915
  article-title: Role of serum Metadherin mRNA expression in the diagnosis and prediction of survival in patients with colorectal cancer
  publication-title: Mol Biol Rep
  doi: 10.1007/s11033-020-05334-5
– volume: 20
  start-page: 100706
  year: 2020
  ident: R7-20230915
  article-title: Serum high-temperature-required protein A2: a potential biomarker for the diagnosis of breast cancer
  publication-title: Gene Rep
  doi: 10.1016/j.genrep.2020.100706
– volume: 25
  start-page: 603
  year: 2010
  ident: R24-20230915
  article-title: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses
  publication-title: Eur J Epidemiol
  doi: 10.1007/s10654-010-9491-z
– volume: 31
  start-page: 3
  year: 2019
  ident: R8-20230915
  article-title: Oct4 expression in gastric carcinoma: association with tumor proliferation, angiogenesis and survival
  publication-title: J Egypt Natl Canc Inst
  doi: 10.1186/s43046-019-0005-0
– volume: 6
  start-page: 716
  year: 2014
  ident: R12-20230915
  article-title: M1 and M2 macrophages: the chicken and the egg of immunity
  publication-title: J Innate Immun
  doi: 10.1159/000364945
– volume: 62
  start-page: 1006
  year: 2009
  ident: R22-20230915
  article-title: Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement
  publication-title: J Clin Epidemiol
  doi: 10.1016/j.jclinepi.2009.06.005
– volume: 15
  start-page: 2303
  year: 2019
  ident: R39-20230915
  article-title: Prognostic impact of tumor-associated macrophage infiltration in esophageal cancer: a meta-analysis
  publication-title: Future Oncol
  doi: 10.2217/fon-2018-0669
– volume: 6
  start-page: 37874
  year: 2016
  ident: R30-20230915
  article-title: Macrophage-dependent tumor cell transendothelial migration is mediated by Notch1/Mena(INV)-initiated invadopodium formation
  publication-title: Sci Rep
  doi: 10.1038/srep37874
SSID ssj0013724
Score 2.4073932
SecondaryResourceType review_article
Snippet To explore the prognostic value of diverse subsets of tumor-associated macrophages (TAMs) in prognosis in patients with nasopharyngeal carcinoma (NPC) using...
SourceID pubmedcentral
proquest
pubmed
crossref
wolterskluwer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage e21999
SubjectTerms Adult
Aged
Biomarkers, Tumor - metabolism
Disease-Free Survival
Female
Humans
Macrophages - metabolism
Male
Middle Aged
Nasopharyngeal Carcinoma - mortality
Nasopharyngeal Neoplasms - mortality
Systematic Review and Meta-Analysis
Young Adult
Title Prognostic significance of tumor-associated macrophages in patients with nasopharyngeal carcinoma: A meta-analysis
URI https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005792-202009250-00005
https://www.ncbi.nlm.nih.gov/pubmed/32991403
https://www.proquest.com/docview/2447552865
https://pubmed.ncbi.nlm.nih.gov/PMC7523791
Volume 99
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdgk6ZJCPE5ysdkJB4xNE5SN7yNtWhCFHjY0HiK7NjeKpZk6loh-Ou5i-20WQsC-hBVjuukvl8ud_bd7wh5YfqJLtIM3ZLEsESnMVPDoWEmUVnBudCaY3Ly5OPg6CR5f5qeLgtdNtklc_Wq-Lkxr-R_pAptIFfMkv0HybaDQgN8B_nCESQMx7-S8edZjXFyyLmKcRgY9dNkAOC-_6KsZ0z6yQerspRYrOtcnhkXOe74VH1yWyWxmoGc_ajOkGi4wAJDVV1Kl7demrlk0rOXrFqzE78xj2bqW3kxn7qo3XZt4dCnfnyV7EOAoV9hAHcSN13cVrMJWnHA0szRjQe16eoaeXg4QiKvBA1HboON-tnx_k5GjjbSfdZ6w3-7LBuRxfCyRELB5cuqDSEMp26SbQ4eAqi47U9fxuPRcgtJ8CTQTGXi9YZr7pKdMErXKllzNdYjZm99rzGa4epbk8ywYpIc3yG3vS9BDxww7pIbprpHdoJQ7pPZEh90FR-0tvQ6PugKPui0ogEfFPFBu_igLT7e0APaQccDcvJufHx4xHyNDVaAqZ4ybjT4-FZLpdTQqigqolT2tYpwxdUOjBZGyKHWwsZWDgret1z2RQF-BEzcUGXxQ7JV1ZV5RKiVPLap0pGJo8QmUgqbgQUPzzxcQg6SHuFhjvPCE9BjHZSLPARCTEb5dRn1yMv2R5eOf-XP3Z8H4eWgJ3HzS1amXlzlHJktU8zD7pE9J8x2wICCHhEdMbcdkIO9e6aanjdc7CLlsciiHmEdQOQui7m5v1RknOFz1c_A32BN0-Pf3sMTsrt8Bp-SrflsYZ6B3TtX-8160b7H-S8GPK1y
linkProvider Ovid
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1db9MwFLXQJgESQnwTPo2E8kSgceI4QepD1WaUsZRJ7WA8RXZsb9OoMyUpiH-Pb5IWygQSeUkkO4mUex0f-557LkIv1SCUBU1gWRIqL5Q08EQcK0-FIikIYVISSE7OZtH0KNw_psc92wJyYSD7rL54Daf2Pw0XUA8HFoaL4f7cnaWf50Pjjufj4Rf3cPQubfepgSXhToblN924o1nLv6IsIdYHWlUh2mZPg9TpbkQJswN49-OnNJ38ijcwEm6Ku1qIvdYnStibbNJpHHYHgbT97TnsEjC9zK-88b2E2Hd93lLff5vA9m6hmz3yxKPOVW6jK8rcQVezPrZ-F1WHVQmsO9uMgdUBHCJwCVxq3KyWZeXx3pRK4iWH0l-n9mdU4zODe3XWGsO2LjYcaiPw6oc5sTAUF1CuyJRL_haP8FI13OO9Eso9dLSXLsZTr6_I4BUW2FGPKGlXhFpyIUSshe8XPuUDKXzYn9ORkkwxHkvJdKB5VJCBJnzACos6LQyNRRLcRzumNOohwpqTQFMhfRX4oQ45ZzqxprIeYl_Bo9BBZP2N86KXK4eqGV_zddg8m-R_GsZBrzY3XXRqHf_u_mJtvNyOKgiVcKPKVZ0T0EGkkLXroAedMTcPDOwMDiqHDmJbZt50AMXu7RZzdtoqdzO77GeJ7yBvyyHyLuc1_5vbPvrP_s_RtekiO8gP3s8-PEbXoRUoLoQ-QTtNtVJPLY5qxLN-EPwEz6MUdw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3rb9MwELdGJ01ICPEmPI2E8omgxInrBCkfqiZlDNpV6gbjU2TH9jaNJlOTgvbf48ujUIaQyJdEsvNQ7mz_znf3O4ReKzeQOY3ALAmUE0jqOyIMlaMCEeWEMCkJJCdPZ8P94-DghJ7soN5jCsln1eVbODXTNFxAORywC4_ig4U9Xozjr_Ys_bKIZ_Z89D5ttqkhSMKeJ5P4yk7i8ruu7eQw7vkZp0lLUtgeBPLub6DdMDRAfoB2Dz-nafLL78BIsCnyaqB2z1P098dsr2XXAOr1OMtbP0rwgVcXTQj8bwvZ5A663SFQPGpV5i7aUcU9tDftfOz30Wq-KiH6zjRjiO6AWCJQDVxqXK-X5crhnUiVxEsOJcDOzKRU4fMCdyytFYbtXVxwqJHAV1fFqYGjOIeyRUW55O_wCC9VzR3eMaI8QMeT9Gi873SVGZzcADzqECWNZaglF0KEWnhe7lHuSuHBPp0eKskU46GUTPuaD3PiasJdlhv0aeBoKCL_IRoUZaEeI6w58TUV0lO-F-iAc6Yjg_uMpphX8GFgIdL_4yzvaMuhesa3rHefT5PsT8FY6M3mpsuWtePf3V_1wsvM6AKXCS9Uua4yAnyIFLJ3LfSoFebmgb5ZyYHt0EJsS8ybDsDcvd1SnJ81DN7MmP8s8izkbClE1ua-Nt9HWUTMFNaQYtEm-d-lT_6z_0u0ZwZF9unD7ONTdBMaIdKF0GdoUK_W6rmBU7V40Y2BnybUFhI
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prognostic+significance+of+tumor-associated+macrophages+in+patients+with+nasopharyngeal+carcinoma%3A+A+meta-analysis&rft.jtitle=Medicine+%28Baltimore%29&rft.au=Chen%2C+Ya-Lian&rft.date=2020-09-25&rft.eissn=1536-5964&rft.volume=99&rft.issue=39&rft.spage=e21999&rft_id=info:doi/10.1097%2FMD.0000000000021999&rft_id=info%3Apmid%2F32991403&rft.externalDocID=32991403
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0025-7974&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0025-7974&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0025-7974&client=summon