Potential Role of Circulating MiR-21 in the Diagnosis and Prognosis of Digestive System Cancer: A Systematic Review and Meta-Analysis

• Published in: Medicine (Baltimore) Vol. 94; no. 50; p. e2123
• Main Authors: Yin, Chengqiang, Zhou, Xiaoying, Dang, Yini, Yan, Jin, Zhang, Guoxin
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc. All rights reserved 01.12.2015; Wolters Kluwer Health
• Subjects: Biomarkers, Tumor; Digestive System Neoplasms - blood; Digestive System Neoplasms - diagnosis; Humans; MicroRNAs - blood; Prognosis; Proportional Hazards Models; ROC Curve; Survival Analysis; Systematic Review and Meta-Analysis

Recent evidences indicate that circulating microRNAs (miRNAs) exhibit aberrant expression in the plasma of patients suffering from cancer compared to normal individuals, suggesting that it may be a useful noninvasion diagnostic method. MiR-21 plays crucial roles in carcinogenesis and can be served a...