Pathophysiological levels of the obesity related peptides resistin and ghrelin increase adhesion molecule expression on human vascular endothelial cells

• Published in: Clinical and experimental pharmacology & physiology Vol. 32; no. 10; pp. 839 - 844
• Main Authors: Skilton, Michael R, Nakhla, Shirley, Sieveking, Daniel P, Caterson, Ian D, Celermajer, David S
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Pty 01.10.2005
• Subjects: atherosclerosis; Cell Adhesion - drug effects; cell adhesion molecules; Cell Adhesion Molecules - biosynthesis; Cells, Cultured; cytokines; Dose-Response Relationship, Drug; E-Selectin - biosynthesis; Endothelial Cells - cytology; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Enzyme-Linked Immunosorbent Assay; Ghrelin; Humans; Insulin - pharmacology; Intercellular Adhesion Molecule-1 - biosynthesis; Leptin - pharmacology; Monocytes - cytology; Monocytes - drug effects; Peptide Hormones - pharmacology; Resistin - pharmacology; Time Factors; Vascular Cell Adhesion Molecule-1 - biosynthesis

SUMMARY 1. In the present study, we sought to determine whether physiological or pathophysiological concentrations of obesity related peptides influence the key early atherogenic events of monocyte adhesion to endothelial cells and adhesion molecule expression using primary human cells. 2. Human umb...