Genetically increased circulating 25(OH)D level reduces the risk of type 2 diabetes in subjects with deficiency of vitamin D: A large-scale Mendelian randomization study

• Published in: Medicine (Baltimore) Vol. 99; no. 51; p. e23672
• Main Authors: Xu, Yingying, Zhou, Yuan, Liu, Jingjing, Wang, Chenfang, Qu, Zhongjie, Wei, Zhili, Zhou, Dan
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 18.12.2020
• Subjects: Adult; Aged; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Female; Genome-Wide Association Study; Humans; Male; Mendelian Randomization Analysis; Middle Aged; Observational Study; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - complications

Observational studies have reported that Vitamin D deficiency and the risk type 2 diabetes are associated, but the causation is unclear. Mendelian randomization (MR) involving genetic variants as instrument variables (IVs) overcomes the reverse-casualty and unmeasured confounding. However, with limi...