Amount and avidity of salivary and serum antibodies against Streptococcus mutans in two groups of human subjects with different dental caries susceptibility

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Published inInfection and Immunity Vol. 43; no. 1; pp. 308 - 313
Main Authors LEHTONEN, O.-P. J, GRAHN, E. M, STAHLBERG, T. H, LAITINEN, L. A
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.01.1984
Subjects
Antibodies, Bacterial - immunology
Bacteriology
Biological and medical sciences
Dental Caries - immunology
Disease Susceptibility
Enzyme-Linked Immunosorbent Assay
Fundamental and applied biological sciences. Psychology
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Microbiology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Saliva - immunology
Streptococcus mutans
Streptococcus mutans - immunology
Human
IgA
Antibody
Dental carie
IgG
Immunoglobulin
Enzyme immunoassay
Immunological method
Streptococcus mutans
Sensitivity
Bacteria
Serum
Saliva
ELISA assay
Online AccessGet full text
ISSN0019-9567
1098-5522
DOI10.1128/iai.43.1.308-313.1984

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Abstract Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue IAI About IAI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy Connect to IAI IAI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0019-9567 Online ISSN: 1098-5522 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to IAI .asm.org, visit: IAI       
AbstractList Immunoglobulin A (IgA) and IgG antibodies against Streptococcus mutans K1R and 10449 were measured in serum and in stimulated whole saliva from two groups of naval recruits, representing high or low caries susceptibility. The antibody assays were performed by using the enzyme-linked immunosorbent assay, and the results were expressed by a method able to estimate the amount of high-avidity and total specific antibodies. As a control, concentrations of salivary total immunoglobulins were related to the amounts of specific antibodies. Further, antibodies were assayed against three antigens, unrelated to the streptococci. No clear differences were observed in serum antibodies between the subjects with high or low caries susceptibility. However, in saliva, low caries susceptibility was associated with a high amount of total antigen-specific IgA, and possibly IgG, against S. mutans. This difference between the groups still existed when the amounts of specific antibodies were related to the amounts of salivary immunoglobulins. There were no differences in the amounts of total specific antibodies against the unrelated antigens. No differences were observed in the estimates of high-avidity anti-S. mutans antibodies between the groups, either in serum or saliva. Thus, within the limitations of the assays and crude antigen, lack of high-avidity antibodies is not responsible for caries susceptibility. Instead, the amount of anti-S. mutans antibodies seems to be linked with caries protection. The results of the present study indicate that salivary antibodies are linked with the control of human dental caries.Immunoglobulin A (IgA) and IgG antibodies against Streptococcus mutans K1R and 10449 were measured in serum and in stimulated whole saliva from two groups of naval recruits, representing high or low caries susceptibility. The antibody assays were performed by using the enzyme-linked immunosorbent assay, and the results were expressed by a method able to estimate the amount of high-avidity and total specific antibodies. As a control, concentrations of salivary total immunoglobulins were related to the amounts of specific antibodies. Further, antibodies were assayed against three antigens, unrelated to the streptococci. No clear differences were observed in serum antibodies between the subjects with high or low caries susceptibility. However, in saliva, low caries susceptibility was associated with a high amount of total antigen-specific IgA, and possibly IgG, against S. mutans. This difference between the groups still existed when the amounts of specific antibodies were related to the amounts of salivary immunoglobulins. There were no differences in the amounts of total specific antibodies against the unrelated antigens. No differences were observed in the estimates of high-avidity anti-S. mutans antibodies between the groups, either in serum or saliva. Thus, within the limitations of the assays and crude antigen, lack of high-avidity antibodies is not responsible for caries susceptibility. Instead, the amount of anti-S. mutans antibodies seems to be linked with caries protection. The results of the present study indicate that salivary antibodies are linked with the control of human dental caries.
Immunoglobulin A (IgA) and IgG antibodies against Streptococcus mutans K1R and 10449 were measured in serum and in stimulated whole saliva from two groups of naval recruits, representing high or low caries susceptibility. The antibody assays were performed by using the enzyme-linked immunosorbent assay, and the results were expressed by a method able to estimate the amount of high-avidity and total specific antibodies. As a control, concentrations of salivary total immunoglobulins were related to the amounts of specific antibodies. Further, antibodies were assayed against three antigens, unrelated to the streptococci. No clear differences were observed in serum antibodies between the subjects with high or low caries susceptibility. However, in saliva, low caries susceptibility was associated with a high amount of total antigen-specific IgA, and possibly IgG, against S. mutans. This difference between the groups still existed when the amounts of specific antibodies were related to the amounts of salivary immunoglobulins. There were no differences in the amounts of total specific antibodies against the unrelated antigens. No differences were observed in the estimates of high-avidity anti-S. mutans antibodies between the groups, either in serum or saliva. Thus, within the limitations of the assays and crude antigen, lack of high-avidity antibodies is not responsible for caries susceptibility. Instead, the amount of anti-S. mutans antibodies seems to be linked with caries protection. The results of the present study indicate that salivary antibodies are linked with the control of human dental caries.
In this study, anti-S. mutans antibodies of IgA and IgG classes in serum and stimulated whole saliva were measured in subjects with high-or low-caries susceptibility. Antibody avidity may have a role in protection against caries. Therefore, in this study, a modified enzyme-linked immunosorbent assay (ELISA) was employed, enabling the authors to perform independent estimations of high-avidity and total antigen-specific antibodies. In addition, salivary and serum totals IgA and IgG were assayed. To evaluate the validity of anti-S. mutans antibodies, three unrelated antigens were also used in the antibody assays.
Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue IAI About IAI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy Connect to IAI IAI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0019-9567 Online ISSN: 1098-5522 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to IAI .asm.org, visit: IAI       
Author E M Gråhn
O P Lehtonen
T H Ståhlberg
L A Laitinen
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Keywords Human
IgA
Antibody
Dental carie
IgG
Immunoglobulin
Enzyme immunoassay
Immunological method
Streptococcus mutans
Sensitivity
Bacteria
Serum
Saliva
ELISA assay
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Snippet Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit...
Immunoglobulin A (IgA) and IgG antibodies against Streptococcus mutans K1R and 10449 were measured in serum and in stimulated whole saliva from two groups of...
In this study, anti-S. mutans antibodies of IgA and IgG classes in serum and stimulated whole saliva were measured in subjects with high-or low-caries...
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StartPage 308
SubjectTerms Antibodies, Bacterial - immunology
Bacteriology
Biological and medical sciences
Dental Caries - immunology
Disease Susceptibility
Enzyme-Linked Immunosorbent Assay
Fundamental and applied biological sciences. Psychology
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Microbiology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Saliva - immunology
Streptococcus mutans
Streptococcus mutans - immunology
Title Amount and avidity of salivary and serum antibodies against Streptococcus mutans in two groups of human subjects with different dental caries susceptibility
URI http://iai.asm.org/content/43/1/308.abstract
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