Analysis of genetic polymorphisms associated with leukoaraiosis in the southern Chinese population: A case–control study

• Published in: Medicine (Baltimore) Vol. 95; no. 35; p. e3857
• Main Authors: Huang, Wen-Qing, Ye, Hui-Ming, Li, Fang-Fang, Yi, Ke-Hui, Zhang, Ya, Cai, Liang-Liang, Lin, Hui-Nuan, Lin, Qing, Tzeng, Chi-Meng
• Format: Journal Article
• Language: English
• Published: United States The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved 01.08.2016; Wolters Kluwer Health
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Aged; Aged, 80 and over; Asian Continental Ancestry Group - genetics; Carrier Proteins - genetics; Case-Control Studies; China; Female; Genetic Predisposition to Disease; Genotype; Humans; Leukoaraiosis - genetics; Male; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; Neoplasm Proteins - genetics; Nuclear Proteins - genetics; Observational Study; Polymorphism, Single Nucleotide; Transcription Factors - genetics; Tripartite Motif Proteins - genetics; Ubiquitin-Protein Ligases - genetics

Leukoaraiosis (LA) is a frequent neuroimaging finding commonly observed on brain MRIs of elderly people with prevalence ranging from 50% to 100%. Multiple susceptibility genes or genetic risk factors for LA have been identified in subjects of European descent. Here, we report the first replication s...