Baicalin, Baicalein, and Lactobacillus Rhamnosus JB3 Alleviated Helicobacter pylori Infections in Vitro and in Vivo

• Published in: Journal of food science Vol. 83; no. 12; pp. 3118 - 3125
• Main Authors: Chen, Mu‐En, Su, Chiu‐Hsian, Yang, Jai‐Sing, Lu, Chi‐Cheng, Hou, Yu‐Chi, Wu, Jin‐Bin, Hsu, Yuan‐Man
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2018
• Subjects: adhesion; AGS cells; animal disease models; anti-inflammatory activity; Antibiotics; baicalein; Baicalin; Biocompatibility; blood serum; C57BL/6 mice; Cancer; Chronic infection; Cytotoxicity; dairy products; epithelium; Gastric cancer; Gastritis; Gene expression; Health promotion; Health risk assessment; Helicobacter pylori; Immunoglobulin A; Immunoglobulin M; In vivo methods and tests; Infections; Inflammation; interleukin-1beta; Interleukins; Intestinal microflora; intestinal microorganisms; Lactobacillus; Lactobacillus rhamnosus; Medicinal plants; Mice; Microbiota; Pathogens; Peptic ulcers; risk reduction; stomach; stomach neoplasms; synergism; Synergistic effect; therapeutics; Toxicity; Ulcers; VacA protein; Virulence; AGS cells; baicalein; Helicobacter pylori; baicalin; C57BL/6 mice; Lactobacillus rhamnosus

Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The flavonoid compounds baicalin and baicalein found in many medicinal plants exhibit an anti‐inflammatory effect. The administration of Lactobacillus strains reducing the risk of H. pylori infecti...