Baicalin, Baicalein, and Lactobacillus Rhamnosus JB3 Alleviated Helicobacter pylori Infections in Vitro and in Vivo

Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The flavonoid compounds baicalin and baicalein found in many medicinal plants exhibit an anti‐inflammatory effect. The administration of Lactobacillus strains reducing the risk of H. pylori infecti...

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Published inJournal of food science Vol. 83; no. 12; pp. 3118 - 3125
Main Authors Chen, Mu‐En, Su, Chiu‐Hsian, Yang, Jai‐Sing, Lu, Chi‐Cheng, Hou, Yu‐Chi, Wu, Jin‐Bin, Hsu, Yuan‐Man
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.12.2018
Subjects
adhesion
AGS cells
animal disease models
anti-inflammatory activity
Antibiotics
baicalein
Baicalin
Biocompatibility
blood serum
C57BL/6 mice
Cancer
Chronic infection
Cytotoxicity
dairy products
epithelium
Gastric cancer
Gastritis
Gene expression
Health promotion
Health risk assessment
Helicobacter pylori
Immunoglobulin A
Immunoglobulin M
In vivo methods and tests
Infections
Inflammation
interleukin-1beta
Interleukins
Intestinal microflora
intestinal microorganisms
Lactobacillus
Lactobacillus rhamnosus
Medicinal plants
Mice
Microbiota
Pathogens
Peptic ulcers
risk reduction
stomach
stomach neoplasms
synergism
Synergistic effect
therapeutics
Toxicity
Ulcers
VacA protein
Virulence
AGS cells
baicalein
Helicobacter pylori
baicalin
C57BL/6 mice
Lactobacillus rhamnosus
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Abstract Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The flavonoid compounds baicalin and baicalein found in many medicinal plants exhibit an anti‐inflammatory effect. The administration of Lactobacillus strains reducing the risk of H. pylori infection is well accepted. In this study, the therapeutic effects against H. pylori infection of baicalin, baicalein, and L. rhamnosus JB3 (LR‐JB3), isolated from a dairy product, were investigated. Compared to baicalin, baicalein exhibited stronger anti‐H. pylori activity and cytotoxicity on human gastric cancer epithelial AGS cells. Baicalin and baicalein both suppressed the vacA gene expression of H. pylori and interfered with the adhesion and invasion ability of H. pylori to AGS cells, as well as decreased H. pylori‐induced interleukin (IL)‐8 expression. In the mice infection model, high dosages of baicalin and baicalein inhibited H. pylori growth in the mice stomachs. Serum IL‐1β levels and H. pylori‐specific serum IgM and IgA levels in mice treated with baicalin and baicalein were decreased. Moreover, a synergistic therapeutic effect of baicalein and LR‐JB3 on eradicating H. pylori infections was observed. Thus, administrating baicalin, baicalein, or LR‐JB3 for an H. pylori infection could offer similar therapeutic effects to administering antibiotics while not disturbing the balance of gut microbiota. This study revealed the effects of baicalin, baicalein, and LR‐JB3 on attenuating the virulence of H. pylori. The synergistic effect with baicalein and LR‐JB3 provides the experimental rationale for testing the reliability, safety, and efficacy of this approach in higher animals and perhaps ultimately in humans to eradicate H. pylori infections. Practical Application Baicalin and baicalein exert health promotion and avoidance of H. pylori infections by interfering with H. pylori growth and virulence. Lactobacillus rhamnosus JB3 was used to reduce the gastric inflammation caused by H. pylori infection.
AbstractList Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The flavonoid compounds baicalin and baicalein found in many medicinal plants exhibit an anti‐inflammatory effect. The administration of Lactobacillus strains reducing the risk of H. pylori infection is well accepted. In this study, the therapeutic effects against H. pylori infection of baicalin, baicalein, and L. rhamnosus JB3 (LR‐JB3), isolated from a dairy product, were investigated. Compared to baicalin, baicalein exhibited stronger anti‐H. pylori activity and cytotoxicity on human gastric cancer epithelial AGS cells. Baicalin and baicalein both suppressed the vacA gene expression of H. pylori and interfered with the adhesion and invasion ability of H. pylori to AGS cells, as well as decreased H. pylori‐induced interleukin (IL)‐8 expression. In the mice infection model, high dosages of baicalin and baicalein inhibited H. pylori growth in the mice stomachs. Serum IL‐1β levels and H. pylori‐specific serum IgM and IgA levels in mice treated with baicalin and baicalein were decreased. Moreover, a synergistic therapeutic effect of baicalein and LR‐JB3 on eradicating H. pylori infections was observed. Thus, administrating baicalin, baicalein, or LR‐JB3 for an H. pylori infection could offer similar therapeutic effects to administering antibiotics while not disturbing the balance of gut microbiota. This study revealed the effects of baicalin, baicalein, and LR‐JB3 on attenuating the virulence of H. pylori. The synergistic effect with baicalein and LR‐JB3 provides the experimental rationale for testing the reliability, safety, and efficacy of this approach in higher animals and perhaps ultimately in humans to eradicate H. pylori infections.Practical ApplicationBaicalin and baicalein exert health promotion and avoidance of H. pylori infections by interfering with H. pylori growth and virulence. Lactobacillus rhamnosus JB3 was used to reduce the gastric inflammation caused by H. pylori infection.
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The flavonoid compounds baicalin and baicalein found in many medicinal plants exhibit an anti-inflammatory effect. The administration of Lactobacillus strains reducing the risk of H. pylori infection is well accepted. In this study, the therapeutic effects against H. pylori infection of baicalin, baicalein, and L. rhamnosus JB3 (LR-JB3), isolated from a dairy product, were investigated. Compared to baicalin, baicalein exhibited stronger anti-H. pylori activity and cytotoxicity on human gastric cancer epithelial AGS cells. Baicalin and baicalein both suppressed the vacA gene expression of H. pylori and interfered with the adhesion and invasion ability of H. pylori to AGS cells, as well as decreased H. pylori-induced interleukin (IL)-8 expression. In the mice infection model, high dosages of baicalin and baicalein inhibited H. pylori growth in the mice stomachs. Serum IL-1β levels and H. pylori-specific serum IgM and IgA levels in mice treated with baicalin and baicalein were decreased. Moreover, a synergistic therapeutic effect of baicalein and LR-JB3 on eradicating H. pylori infections was observed. Thus, administrating baicalin, baicalein, or LR-JB3 for an H. pylori infection could offer similar therapeutic effects to administering antibiotics while not disturbing the balance of gut microbiota. This study revealed the effects of baicalin, baicalein, and LR-JB3 on attenuating the virulence of H. pylori. The synergistic effect with baicalein and LR-JB3 provides the experimental rationale for testing the reliability, safety, and efficacy of this approach in higher animals and perhaps ultimately in humans to eradicate H. pylori infections. PRACTICAL APPLICATION: Baicalin and baicalein exert health promotion and avoidance of H. pylori infections by interfering with H. pylori growth and virulence. Lactobacillus rhamnosus JB3 was used to reduce the gastric inflammation caused by H. pylori infection.Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The flavonoid compounds baicalin and baicalein found in many medicinal plants exhibit an anti-inflammatory effect. The administration of Lactobacillus strains reducing the risk of H. pylori infection is well accepted. In this study, the therapeutic effects against H. pylori infection of baicalin, baicalein, and L. rhamnosus JB3 (LR-JB3), isolated from a dairy product, were investigated. Compared to baicalin, baicalein exhibited stronger anti-H. pylori activity and cytotoxicity on human gastric cancer epithelial AGS cells. Baicalin and baicalein both suppressed the vacA gene expression of H. pylori and interfered with the adhesion and invasion ability of H. pylori to AGS cells, as well as decreased H. pylori-induced interleukin (IL)-8 expression. In the mice infection model, high dosages of baicalin and baicalein inhibited H. pylori growth in the mice stomachs. Serum IL-1β levels and H. pylori-specific serum IgM and IgA levels in mice treated with baicalin and baicalein were decreased. Moreover, a synergistic therapeutic effect of baicalein and LR-JB3 on eradicating H. pylori infections was observed. Thus, administrating baicalin, baicalein, or LR-JB3 for an H. pylori infection could offer similar therapeutic effects to administering antibiotics while not disturbing the balance of gut microbiota. This study revealed the effects of baicalin, baicalein, and LR-JB3 on attenuating the virulence of H. pylori. The synergistic effect with baicalein and LR-JB3 provides the experimental rationale for testing the reliability, safety, and efficacy of this approach in higher animals and perhaps ultimately in humans to eradicate H. pylori infections. PRACTICAL APPLICATION: Baicalin and baicalein exert health promotion and avoidance of H. pylori infections by interfering with H. pylori growth and virulence. Lactobacillus rhamnosus JB3 was used to reduce the gastric inflammation caused by H. pylori infection.
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The flavonoid compounds baicalin and baicalein found in many medicinal plants exhibit an anti-inflammatory effect. The administration of Lactobacillus strains reducing the risk of H. pylori infection is well accepted. In this study, the therapeutic effects against H. pylori infection of baicalin, baicalein, and L. rhamnosus JB3 (LR-JB3), isolated from a dairy product, were investigated. Compared to baicalin, baicalein exhibited stronger anti-H. pylori activity and cytotoxicity on human gastric cancer epithelial AGS cells. Baicalin and baicalein both suppressed the vacA gene expression of H. pylori and interfered with the adhesion and invasion ability of H. pylori to AGS cells, as well as decreased H. pylori-induced interleukin (IL)-8 expression. In the mice infection model, high dosages of baicalin and baicalein inhibited H. pylori growth in the mice stomachs. Serum IL-1β levels and H. pylori-specific serum IgM and IgA levels in mice treated with baicalin and baicalein were decreased. Moreover, a synergistic therapeutic effect of baicalein and LR-JB3 on eradicating H. pylori infections was observed. Thus, administrating baicalin, baicalein, or LR-JB3 for an H. pylori infection could offer similar therapeutic effects to administering antibiotics while not disturbing the balance of gut microbiota. This study revealed the effects of baicalin, baicalein, and LR-JB3 on attenuating the virulence of H. pylori. The synergistic effect with baicalein and LR-JB3 provides the experimental rationale for testing the reliability, safety, and efficacy of this approach in higher animals and perhaps ultimately in humans to eradicate H. pylori infections. PRACTICAL APPLICATION: Baicalin and baicalein exert health promotion and avoidance of H. pylori infections by interfering with H. pylori growth and virulence. Lactobacillus rhamnosus JB3 was used to reduce the gastric inflammation caused by H. pylori infection.
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The flavonoid compounds baicalin and baicalein found in many medicinal plants exhibit an anti‐inflammatory effect. The administration of Lactobacillus strains reducing the risk of H. pylori infection is well accepted. In this study, the therapeutic effects against H. pylori infection of baicalin, baicalein, and L. rhamnosus JB3 (LR‐JB3), isolated from a dairy product, were investigated. Compared to baicalin, baicalein exhibited stronger anti‐H. pylori activity and cytotoxicity on human gastric cancer epithelial AGS cells. Baicalin and baicalein both suppressed the vacA gene expression of H. pylori and interfered with the adhesion and invasion ability of H. pylori to AGS cells, as well as decreased H. pylori‐induced interleukin (IL)‐8 expression. In the mice infection model, high dosages of baicalin and baicalein inhibited H. pylori growth in the mice stomachs. Serum IL‐1β levels and H. pylori‐specific serum IgM and IgA levels in mice treated with baicalin and baicalein were decreased. Moreover, a synergistic therapeutic effect of baicalein and LR‐JB3 on eradicating H. pylori infections was observed. Thus, administrating baicalin, baicalein, or LR‐JB3 for an H. pylori infection could offer similar therapeutic effects to administering antibiotics while not disturbing the balance of gut microbiota. This study revealed the effects of baicalin, baicalein, and LR‐JB3 on attenuating the virulence of H. pylori. The synergistic effect with baicalein and LR‐JB3 provides the experimental rationale for testing the reliability, safety, and efficacy of this approach in higher animals and perhaps ultimately in humans to eradicate H. pylori infections. Practical Application Baicalin and baicalein exert health promotion and avoidance of H. pylori infections by interfering with H. pylori growth and virulence. Lactobacillus rhamnosus JB3 was used to reduce the gastric inflammation caused by H. pylori infection.
Author Yang, Jai‐Sing
Hou, Yu‐Chi
Su, Chiu‐Hsian
Hsu, Yuan‐Man
Chen, Mu‐En
Lu, Chi‐Cheng
Wu, Jin‐Bin
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  surname: Chen
  fullname: Chen, Mu‐En
  organization: China Medical Univ
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  surname: Su
  fullname: Su, Chiu‐Hsian
  organization: China Medical Univ
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  givenname: Jai‐Sing
  surname: Yang
  fullname: Yang, Jai‐Sing
  organization: China Medical Univ
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  givenname: Chi‐Cheng
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  fullname: Lu, Chi‐Cheng
  organization: Natl. Taiwan Univ. of Sport
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  givenname: Yu‐Chi
  surname: Hou
  fullname: Hou, Yu‐Chi
  organization: China Medical Univ
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  givenname: Jin‐Bin
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  surname: Hsu
  fullname: Hsu, Yuan‐Man
  email: yuanmh@mail.cmu.edu.tw
  organization: China Medical Univ
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Issue 12
Keywords AGS cells
baicalein
Helicobacter pylori
baicalin
C57BL/6 mice
Lactobacillus rhamnosus
Language English
License 2018 Institute of Food Technologists®.
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Snippet Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The flavonoid compounds baicalin and baicalein found in...
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SubjectTerms adhesion
AGS cells
animal disease models
anti-inflammatory activity
Antibiotics
baicalein
Baicalin
Biocompatibility
blood serum
C57BL/6 mice
Cancer
Chronic infection
Cytotoxicity
dairy products
epithelium
Gastric cancer
Gastritis
Gene expression
Health promotion
Health risk assessment
Helicobacter pylori
Immunoglobulin A
Immunoglobulin M
In vivo methods and tests
Infections
Inflammation
interleukin-1beta
Interleukins
Intestinal microflora
intestinal microorganisms
Lactobacillus
Lactobacillus rhamnosus
Medicinal plants
Mice
Microbiota
Pathogens
Peptic ulcers
risk reduction
stomach
stomach neoplasms
synergism
Synergistic effect
therapeutics
Toxicity
Ulcers
VacA protein
Virulence
Title Baicalin, Baicalein, and Lactobacillus Rhamnosus JB3 Alleviated Helicobacter pylori Infections in Vitro and in Vivo
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2F1750-3841.14372
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Volume 83
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