In vitro anti-inflammatory effects of vitamin D supplementation may be blurred in hemodialysis patients

• Published in: Clinics (São Paulo, Brazil) Vol. 76; p. e1821
• Main Authors: Gregório, Paulo C., Bucharles, Sergio, Cunha, Regiane S. da, Braga, Tárcio, Almeida, Ana Clara, Henneberg, Railson, Stinghen, Andréa E.M., Barreto, Fellype C.
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Elsevier España, S.L.U 2021; Faculdade de Medicina / USP; Elsevier España
• Subjects: Anti-Inflammatory Agents - therapeutic use; Cholecalciferol - therapeutic use; Dietary Supplements; Hemodialysis; hs-CRP; Humans; Inflammation; Interleukin-1β; MEDICINE, GENERAL & INTERNAL; Mineral metabolism; Original; Parathyroid Hormone - therapeutic use; Renal Dialysis; Secondary hyperparathyroidism; Vitamin D; Vitamin D Deficiency; Vitamin D; Hemodialysis; Interleukin-1β; Inflammation; hs-CRP; Secondary hyperparathyroidism; Mineral metabolism

This study aimed to evaluate the potential anti-inflammatory effects of vitamin D supplementation under uremic conditions, both in vivo and in vitro, and its effects on the parameters of mineral metabolism. Thirty-two hemodialysis patients were randomly assigned to receive placebo (N=14) or cholecal...