Current smoking predicts inadequate response to methotrexate monotherapy in rheumatoid arthritis patients naïve to DMARDs: Results from a retrospective cohort study

• Published in: Medicine (Baltimore) Vol. 100; no. 17; p. e25481
• Main Authors: Floris, Alberto, Perra, Daniela, Cangemi, Ignazio, Congia, Mattia, Chessa, Elisabetta, Angioni, Maria Maddalena, Mangoni, Arduino Aleksander, Erre, Gian Luca, Mathieu, Alessandro, Piga, Matteo, Cauli, Alberto
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 30.04.2021
• Subjects: Adult; Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - drug therapy; Female; Humans; Induction Chemotherapy; Male; Methotrexate - therapeutic use; Middle Aged; Observational Study; Retrospective Studies; Severity of Illness Index; Smoking - adverse effects; Treatment Failure

Identifying predictors of inadequate response to methotrexate (MTX) in rheumatoid arthritis (RA) is key to move from a "trial and error" to a "personalized medicine" treatment approach where patients less likely to adequately respond to MTX monotherapy could start combination the...