A survey of electrokinetically‐driven microfluidics for cancer cells manipulation

Cancer is one of the leading causes of annual deaths worldwide, accounting for nearly 10 million deaths each year. Metastasis, the process by which cancer spreads across the patient's body, is the main cause of death in cancer patients. Because the rising trend observed in statistics of new can...

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Published inElectrophoresis Vol. 42; no. 5; pp. 605 - 625
Main Authors Romero‐Soto, Fabian O., Polanco‐Oliva, Maria I., Gallo‐Villanueva, Roberto C., Martinez‐Chapa, Sergio O., Perez‐Gonzalez, Victor H.
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.03.2021
Subjects
Biomarkers
Body fluids
Cancer
Dielectrophoresis
Electrokinetics
Electrophoresis
Fatalities
Growth factors
Lab‐on‐a‐Chip
Microfluidics
Miniaturization
State-of-the-art reviews
Dielectrophoresis
Lab-on-a-Chip
Microfluidics
Electrokinetics
Cancer
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Summary:Cancer is one of the leading causes of annual deaths worldwide, accounting for nearly 10 million deaths each year. Metastasis, the process by which cancer spreads across the patient's body, is the main cause of death in cancer patients. Because the rising trend observed in statistics of new cancer cases and cancer‐related deaths does not allow for an optimistic viewpoint on the future—in relation to this terrible disease—the scientific community has sought methods to enable early detection of cancer and prevent the apparition of metastatic tumors. One such method is known as liquid biopsy, wherein a sample is taken from a bodily fluid and analyzed for the presence of CTCs or other cancer biomarkers (e.g., growth factors). With this objective, interest is growing by year in electrokinetically‐driven microfluidics applied for the concentration, capture, filtration, transportation, and characterization of CTCs. Electrokinetic techniques—electrophoresis, dielectrophoresis, electrorotation, and electrothermal and EOF—have great potential for miniaturization and integration with electronic instrumentation for the development of point‐of‐care devices, which can become a tool for early cancer diagnostics and for the design of personalized therapeutics. In this contribution, we review the state of the art of electrokinetically‐driven microfluidics for cancer cells manipulation.
Bibliography:ObjectType-Article-2
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ISSN:0173-0835
1522-2683
DOI:10.1002/elps.202000221