In Vivo Optical Properties of Melanocytic Skin Lesions: Common Nevi, Dysplastic Nevi and Malignant Melanoma
We present an in vivo study of the optical properties of common nevi, dysplastic nevi and malignant melanoma skin lesions in human subjects. Reflectance spectra were measured on 1379 skin lesions, in the visible and near‐infrared spectral regions, using a spectral imaging system, in a clinical setti...
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| Published in | Photochemistry and photobiology Vol. 86; no. 1; pp. 236 - 240 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.2010
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0031-8655 1751-1097 1751-1097 |
| DOI | 10.1111/j.1751-1097.2009.00630.x |
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| Abstract | We present an in vivo study of the optical properties of common nevi, dysplastic nevi and malignant melanoma skin lesions in human subjects. Reflectance spectra were measured on 1379 skin lesions, in the visible and near‐infrared spectral regions, using a spectral imaging system, in a clinical setting. Analysis of the data using a reflectance model revealed differences between the optical properties of melanin present in nevi and melanoma lesions. These differences, which are in agreement with our previous observations on average reflectance spectra, may be potentially useful for the noninvasive characterization of pigmented skin lesions and the early diagnosis of melanoma. |
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| AbstractList | We present an in vivo study of the optical properties of common nevi, dysplastic nevi and malignant melanoma skin lesions in human subjects. Reflectance spectra were measured on 1379 skin lesions, in the visible and near-infrared spectral regions, using a spectral imaging system, in a clinical setting. Analysis of the data using a reflectance model revealed differences between the optical properties of melanin present in nevi and melanoma lesions. These differences, which are in agreement with our previous observations on average reflectance spectra, may be potentially useful for the noninvasive characterization of pigmented skin lesions and the early diagnosis of melanoma. We present an in vivo study of the optical properties of common nevi, dysplastic nevi and malignant melanoma skin lesions in human subjects. Reflectance spectra were measured on 1379 skin lesions, in the visible and near-infrared spectral regions, using a spectral imaging system, in a clinical setting. Analysis of the data using a reflectance model revealed differences between the optical properties of melanin present in nevi and melanoma lesions. These differences, which are in agreement with our previous observations on average reflectance spectra, may be potentially useful for the noninvasive characterization of pigmented skin lesions and the early diagnosis of melanoma.We present an in vivo study of the optical properties of common nevi, dysplastic nevi and malignant melanoma skin lesions in human subjects. Reflectance spectra were measured on 1379 skin lesions, in the visible and near-infrared spectral regions, using a spectral imaging system, in a clinical setting. Analysis of the data using a reflectance model revealed differences between the optical properties of melanin present in nevi and melanoma lesions. These differences, which are in agreement with our previous observations on average reflectance spectra, may be potentially useful for the noninvasive characterization of pigmented skin lesions and the early diagnosis of melanoma. We present an in vivo study of the optical properties of common nevi, dysplastic nevi and malignant melanoma skin lesions in human subjects. Reflectance spectra were measured on 1379 skin lesions, in the visible and near‐infrared spectral regions, using a spectral imaging system, in a clinical setting. Analysis of the data using a reflectance model revealed differences between the optical properties of melanin present in nevi and melanoma lesions. These differences, which are in agreement with our previous observations on average reflectance spectra, may be potentially useful for the noninvasive characterization of pigmented skin lesions and the early diagnosis of melanoma. |
| Author | Zonios, George Dimou, Aikaterini Carrara, Mauro Marchesini, Renato |
| Author_xml | – sequence: 1 givenname: George surname: Zonios fullname: Zonios, George email: gzonios@alum.mit.edu organization: Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece – sequence: 2 givenname: Aikaterini surname: Dimou fullname: Dimou, Aikaterini organization: Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece – sequence: 3 givenname: Mauro surname: Carrara fullname: Carrara, Mauro organization: Fondazione Istituto Nazionale Tumori, Medical Physics Unit, Milan, Italy – sequence: 4 givenname: Renato surname: Marchesini fullname: Marchesini, Renato organization: Fondazione Istituto Nazionale Tumori, Medical Physics Unit, Milan, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19845538$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1117/1.3080140 10.1101/gad.1437206 10.1016/S0010-4655(98)00005-8 10.1364/AO.48.003490 10.1088/0031-9155/53/3/008 10.1016/S0889-8588(05)70020-4 10.1002/bies.950140111 10.1117/1.2844710 10.1088/0031-9155/50/8/004 10.1111/j.1600-0749.2006.00345.x 10.1364/OE.14.008661 10.1177/030089160709300210 10.1111/j.1600-0749.2004.0165_2.x 10.1007/s10434-999-0467-8 10.1046/j.1365-2133.146.s61.3.x 10.1364/OE.16.008263 10.1034/j.1600-0749.2003.00037.x |
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| References | Zonios, G. and A. Dimou (2008) Melanin optical properties provide evidence for chemical and structural disorder in vivo. Opt. Express 16, 8263-8268. Zonios, G. and A. Dimou (2006) Modeling diffuse reflectance from semi-infinite turbid media: Application to the study of skin optical properties. Opt. Express 14, 8661-8674. McMasters, K. M., V. K. Sondak, M. T. Lotze and M. I. Ross (1999) Recent advances in melanoma staging and therapy. Ann. Surg. Oncol. 6, 467-475. Chin, L., L. A. Garraway and D. E. Fisher (2006) Malignant melanoma: Genetics and therapeutics in the genomic era. Genes Dev. 20, 2149-2182. Meredith, P. and T. Sarna (2006) The physical and chemical properties of eumelanin. Pigment Cell Res. 19, 572-594. Barnhill, R. L., K. Fandrey, M. A. Levy, M. C. Mihm Jr and B. Hyman (1992) Angiogenesis and tumor progression of melanoma. Quantification of vascularity in melanocytic nevi and cutaneous malignant melanoma. Lab. Invest. 67, 331-337. Byers, H. R. and J. Bhawan (1998) Pathologic parameters in the diagnosis and prognosis of primary cutaneous melanoma. Hematol. Oncol. Clin. North Am. 12, 717-735. Zonios, G., A. Dimou, I. Bassukas, D. Galaris, A. Tsolakidis and E. Kaxiras (2008) Melanin absorption spectroscopy: New method for noninvasive skin investigation and melanoma detection. J. Biomed. Opt. 13, 014017. Binzoni, T., A. Vogel, A. H. Gandjbakhche and R. Marchesini (2008) Detection limits of multi-spectral optical imaging under the skin surface. Phys. Med. Biol. 53, 617-636. Hill, H. Z. (1992) The function of melanin or 6 blind people examine an elephant. Bioessays 14, 49-56. Mantis, G. and G. Zonios (2009) Simple two-layer reflectance model for biological tissue applications. Appl. Opt. 48, 3490-3496. Marchesini, R., A. Bono and M. Carrara (2009) In vivo characterization of melanin in melanocytic lesions: Spectroscopic study on 1671 pigmented skin lesions. J. Biomed. Opt. 14, 014027. Papageorgiou, D. G., I. N. Demetropoulos and I. E. Lagaris (1998) MERLIN-3.0-A multidimensional optimization environment. Comput. Phys. Commun. 109, 227-249. Simon, J. D. and S. Ito (2004) The chemical structure of melanin. Pigment Cell Res. 17, 423-424. Tomatis, S., M. Carrara, A. Bono, C. Bartoli, M. Lualdi, G. Tragni, A. Colombo and R. Marchesini (2005) Automated melanoma detection with a novel multispectral imaging system: Results of a prospective study. Phys. Med. Biol. 30, 1675-1687. Ortonne, J. P. (2002) Photoprotective properties of skin melanin. Br. J. Dermatol. 146, 7-10. Ito, S. (2003) A chemist's view of melanogenesis. Pigment Cell Res. 16, 230-236. Marchesini, R., A. Bono, S. Tomatis, C. Bartoli, A. Colombo, M. Lualdi and M. Carrara (2007) In vivo evaluation of melanoma thickness by multispectral imaging and an artificial neural network. A retrospective study on 250 cases of cutaneous melanoma. Tumori 93, 170-177. 2009; 14 2006; 20 2004; 17 2002; 146 2006; 14 2008; 16 2005; 30 2003; 16 2006; 19 2008; 13 1998; 109 2007; 93 1992; 14 2008; 53 1999; 6 1992; 67 1998; 12 2009; 48 e_1_2_5_14_2 e_1_2_5_13_2 e_1_2_5_9_2 e_1_2_5_16_2 Barnhill R. L. (e_1_2_5_17_2) 1992; 67 e_1_2_5_8_2 e_1_2_5_15_2 e_1_2_5_7_2 e_1_2_5_10_2 e_1_2_5_6_2 e_1_2_5_5_2 e_1_2_5_12_2 e_1_2_5_4_2 e_1_2_5_11_2 e_1_2_5_3_2 e_1_2_5_2_2 e_1_2_5_18_2 e_1_2_5_19_2 |
| References_xml | – reference: Meredith, P. and T. Sarna (2006) The physical and chemical properties of eumelanin. Pigment Cell Res. 19, 572-594. – reference: Zonios, G., A. Dimou, I. Bassukas, D. Galaris, A. Tsolakidis and E. Kaxiras (2008) Melanin absorption spectroscopy: New method for noninvasive skin investigation and melanoma detection. J. Biomed. Opt. 13, 014017. – reference: Zonios, G. and A. Dimou (2006) Modeling diffuse reflectance from semi-infinite turbid media: Application to the study of skin optical properties. Opt. Express 14, 8661-8674. – reference: Chin, L., L. A. Garraway and D. E. Fisher (2006) Malignant melanoma: Genetics and therapeutics in the genomic era. Genes Dev. 20, 2149-2182. – reference: Barnhill, R. L., K. Fandrey, M. A. Levy, M. C. Mihm Jr and B. Hyman (1992) Angiogenesis and tumor progression of melanoma. Quantification of vascularity in melanocytic nevi and cutaneous malignant melanoma. Lab. Invest. 67, 331-337. – reference: Simon, J. D. and S. Ito (2004) The chemical structure of melanin. Pigment Cell Res. 17, 423-424. – reference: Byers, H. R. and J. Bhawan (1998) Pathologic parameters in the diagnosis and prognosis of primary cutaneous melanoma. Hematol. Oncol. Clin. North Am. 12, 717-735. – reference: Tomatis, S., M. Carrara, A. Bono, C. Bartoli, M. Lualdi, G. Tragni, A. Colombo and R. Marchesini (2005) Automated melanoma detection with a novel multispectral imaging system: Results of a prospective study. Phys. Med. Biol. 30, 1675-1687. – reference: Papageorgiou, D. G., I. N. Demetropoulos and I. E. Lagaris (1998) MERLIN-3.0-A multidimensional optimization environment. Comput. Phys. Commun. 109, 227-249. – reference: Mantis, G. and G. Zonios (2009) Simple two-layer reflectance model for biological tissue applications. Appl. Opt. 48, 3490-3496. – reference: Marchesini, R., A. Bono, S. Tomatis, C. Bartoli, A. Colombo, M. Lualdi and M. Carrara (2007) In vivo evaluation of melanoma thickness by multispectral imaging and an artificial neural network. A retrospective study on 250 cases of cutaneous melanoma. Tumori 93, 170-177. – reference: Zonios, G. and A. Dimou (2008) Melanin optical properties provide evidence for chemical and structural disorder in vivo. Opt. Express 16, 8263-8268. – reference: Marchesini, R., A. Bono and M. Carrara (2009) In vivo characterization of melanin in melanocytic lesions: Spectroscopic study on 1671 pigmented skin lesions. J. Biomed. Opt. 14, 014027. – reference: Ito, S. (2003) A chemist's view of melanogenesis. Pigment Cell Res. 16, 230-236. – reference: Hill, H. Z. (1992) The function of melanin or 6 blind people examine an elephant. Bioessays 14, 49-56. – reference: McMasters, K. M., V. K. Sondak, M. T. Lotze and M. I. Ross (1999) Recent advances in melanoma staging and therapy. Ann. Surg. Oncol. 6, 467-475. – reference: Ortonne, J. P. (2002) Photoprotective properties of skin melanin. Br. J. Dermatol. 146, 7-10. – reference: Binzoni, T., A. Vogel, A. H. Gandjbakhche and R. Marchesini (2008) Detection limits of multi-spectral optical imaging under the skin surface. Phys. Med. Biol. 53, 617-636. – volume: 109 start-page: 227 year: 1998 end-page: 249 article-title: MERLIN‐3.0—A multidimensional optimization environment publication-title: Comput. Phys. Commun. – volume: 16 start-page: 8263 year: 2008 end-page: 8268 article-title: Melanin optical properties provide evidence for chemical and structural disorder publication-title: Opt. Express – volume: 48 start-page: 3490 year: 2009 end-page: 3496 article-title: Simple two‐layer reflectance model for biological tissue applications publication-title: Appl. Opt. – volume: 146 start-page: 7 year: 2002 end-page: 10 article-title: Photoprotective properties of skin melanin publication-title: Br. J. 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| Snippet | We present an in vivo study of the optical properties of common nevi, dysplastic nevi and malignant melanoma skin lesions in human subjects. Reflectance... We present an in vivo study of the optical properties of common nevi, dysplastic nevi and malignant melanoma skin lesions in human subjects. Reflectance... |
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| SubjectTerms | Dysplastic Nevus Syndrome - pathology Humans Melanins Melanocytes Melanoma - diagnosis Melanoma - pathology Nevus, Pigmented - pathology Spectrum Analysis |
| Title | In Vivo Optical Properties of Melanocytic Skin Lesions: Common Nevi, Dysplastic Nevi and Malignant Melanoma |
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