Investigating the shared genetic information between serum concentration levels of liver enzymes and cholelithiasis

• Published in: BMC gastroenterology Vol. 25; no. 1; pp. 564 - 18
• Main Authors: Tian, Wenhao, Wu, Zixin, Yang, Wen, Wang, Hongyang, Feng, Qiyu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.08.2025; BioMed Central; BMC
• Subjects: Alanine Transaminase - blood; Alanine Transaminase - genetics; Alkaline Phosphatase - blood; Alkaline Phosphatase - genetics; Cholelithiasis; Cholelithiasis - blood; Cholelithiasis - enzymology; Cholelithiasis - genetics; Enzymes; Gallstones; gamma-Glutamyltransferase - blood; gamma-Glutamyltransferase - genetics; Genetic aspects; Genetic Predisposition to Disease; Genome-Wide Association Study; GWAS; Health aspects; Humans; Liver; Liver - enzymology; Liver enzymes; Liver injury; Medical research; Medicine, Experimental; Mendelian Randomization Analysis; Physiological aspects; Polymorphism, Single Nucleotide; Shared genetic information; China; Liver enzymes; GWAS; Shared genetic information; Cholelithiasis; Liver injury

Liver injury is associated with cholelithiasis, with changes in liver enzyme levels potentially influencing cholelithiasis risk. This study investigates the shared genetic basis between serum levels of four liver enzymes and cholelithiasis using summary data from large-scale genome-wide association...