TNF-α Gene Promoter -238G>A and -308G>A Polymorphisms Alter Risk of Psoriasis Vulgaris: A Meta-Analysis

• Published in: Journal of investigative dermatology Vol. 127; no. 8; pp. 1886 - 1892
• Main Authors: Li, Chunying, Wang, Gang, Gao, Ying, Liu, Ling, Gao, Tianwen
• Format: Journal Article
• Language: English
• Published: Danvers, MA Elsevier Inc 01.08.2007; Nature Publishing
• Subjects: Biological and medical sciences; biomarkers; Case-Control Studies; Cytokines; Dermatology; Etiology; Gene polymorphism; Genetic Predisposition to Disease; Genotype; Inflammation; Internet; Medical sciences; Nuchal Cord; Promoter Regions, Genetic; Promoters; Psoriasis - etiology; Psoriasis - genetics; psoriasis vulgaris; Psoriasis. Parapsoriasis. Lichen; Reviews; Risk Factors; Transcription; Tumor necrosis factor- alpha; Tumor Necrosis Factor-alpha - genetics; Skin disease; Genetic variability; Psoriasis; Dermatology; Cytokine; Genotype; Risk; Epidemiology; Metaanalysis; Promoter; Gene; Risk factor; Genetics; Tumor necrosis factor α; Polymorphism

Tumor necrosis factor-α (TNF-α) is a major proinflammatory cytokine and involved in the etiology of psoriasis. The -238G>A and -308G>A polymorphisms influence the transcription of the TNF-α gene and have been implicated in psoriasis risk. However, the results from the published studies on the...