Development strategies and application of antimicrobial peptides as future alternatives to in-feed antibiotics

The use of in-feed antibiotics has been widely restricted due to the significant environmental pollution and food safety concerns they have caused. Antimicrobial peptides (AMPs) have attracted widespread attention as potential future alternatives to in-feed antibiotics owing to their demonstrated an...

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Published inThe Science of the total environment Vol. 927; p. 172150
Main Authors Liang, Qingping, Liu, Zhemin, Liang, Ziyu, Zhu, Changliang, Li, Dongyu, Kong, Qing, Mou, Haijin
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2024
Subjects
Alternative to in-feed antibiotics
animal husbandry
Antimicrobial peptides
antimicrobial properties
Development strategies
environment
feed industry
fermentation
food safety
Global health
Optimization of structural parameters
pollution
Sequence modification
Development strategies
Global health
Sequence modification
Optimization of structural parameters
Alternative to in-feed antibiotics
Antimicrobial peptides
Online AccessGet full text
ISSN0048-9697
1879-1026
1879-1026
DOI10.1016/j.scitotenv.2024.172150

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Abstract The use of in-feed antibiotics has been widely restricted due to the significant environmental pollution and food safety concerns they have caused. Antimicrobial peptides (AMPs) have attracted widespread attention as potential future alternatives to in-feed antibiotics owing to their demonstrated antimicrobial activity and environment friendly characteristics. However, the challenges of weak bioactivity, immature stability, and low production yields of natural AMPs impede practical application in the feed industry. To address these problems, efforts have been made to develop strategies for approaching the AMPs with enhanced properties. Herein, we summarize approaches to improving the properties of AMPs as potential alternatives to in-feed antibiotics, mainly including optimization of structural parameters, sequence modification, selection of microbial hosts, fusion expression, and industrially fermentation control. Additionally, the potential for application of AMPs in animal husbandry is discussed. This comprehensive review lays a strong theoretical foundation for the development of in-feed AMPs to achieve the public health globally. [Display omitted] •Antimicrobial peptides (AMPs) are potential antibiotic alternatives for application in feed.•Multiple mechanisms and broad-spectrum of AMPs reduce microbial resistance emergence.•AMPs promote animal growth, regulate gut microbiota, and improve disease resistance.•Weak activity and stability, and low yield are limitations for AMPs application.•Development strategies like gene engineering may improve in-feed AMPs properties.
AbstractList The use of in-feed antibiotics has been widely restricted due to the significant environmental pollution and food safety concerns they have caused. Antimicrobial peptides (AMPs) have attracted widespread attention as potential future alternatives to in-feed antibiotics owing to their demonstrated antimicrobial activity and environment friendly characteristics. However, the challenges of weak bioactivity, immature stability, and low production yields of natural AMPs impede practical application in the feed industry. To address these problems, efforts have been made to develop strategies for approaching the AMPs with enhanced properties. Herein, we summarize approaches to improving the properties of AMPs as potential alternatives to in-feed antibiotics, mainly including optimization of structural parameters, sequence modification, selection of microbial hosts, fusion expression, and industrially fermentation control. Additionally, the potential for application of AMPs in animal husbandry is discussed. This comprehensive review lays a strong theoretical foundation for the development of in-feed AMPs to achieve the public health globally.The use of in-feed antibiotics has been widely restricted due to the significant environmental pollution and food safety concerns they have caused. Antimicrobial peptides (AMPs) have attracted widespread attention as potential future alternatives to in-feed antibiotics owing to their demonstrated antimicrobial activity and environment friendly characteristics. However, the challenges of weak bioactivity, immature stability, and low production yields of natural AMPs impede practical application in the feed industry. To address these problems, efforts have been made to develop strategies for approaching the AMPs with enhanced properties. Herein, we summarize approaches to improving the properties of AMPs as potential alternatives to in-feed antibiotics, mainly including optimization of structural parameters, sequence modification, selection of microbial hosts, fusion expression, and industrially fermentation control. Additionally, the potential for application of AMPs in animal husbandry is discussed. This comprehensive review lays a strong theoretical foundation for the development of in-feed AMPs to achieve the public health globally.
The use of in-feed antibiotics has been widely restricted due to the significant environmental pollution and food safety concerns they have caused. Antimicrobial peptides (AMPs) have attracted widespread attention as potential future alternatives to in-feed antibiotics owing to their demonstrated antimicrobial activity and environment friendly characteristics. However, the challenges of weak bioactivity, immature stability, and low production yields of natural AMPs impede practical application in the feed industry. To address these problems, efforts have been made to develop strategies for approaching the AMPs with enhanced properties. Herein, we summarize approaches to improving the properties of AMPs as potential alternatives to in-feed antibiotics, mainly including optimization of structural parameters, sequence modification, selection of microbial hosts, fusion expression, and industrially fermentation control. Additionally, the potential for application of AMPs in animal husbandry is discussed. This comprehensive review lays a strong theoretical foundation for the development of in-feed AMPs to achieve the public health globally.
The use of in-feed antibiotics has been widely restricted due to the significant environmental pollution and food safety concerns they have caused. Antimicrobial peptides (AMPs) have attracted widespread attention as potential future alternatives to in-feed antibiotics owing to their demonstrated antimicrobial activity and environment friendly characteristics. However, the challenges of weak bioactivity, immature stability, and low production yields of natural AMPs impede practical application in the feed industry. To address these problems, efforts have been made to develop strategies for approaching the AMPs with enhanced properties. Herein, we summarize approaches to improving the properties of AMPs as potential alternatives to in-feed antibiotics, mainly including optimization of structural parameters, sequence modification, selection of microbial hosts, fusion expression, and industrially fermentation control. Additionally, the potential for application of AMPs in animal husbandry is discussed. This comprehensive review lays a strong theoretical foundation for the development of in-feed AMPs to achieve the public health globally. [Display omitted] •Antimicrobial peptides (AMPs) are potential antibiotic alternatives for application in feed.•Multiple mechanisms and broad-spectrum of AMPs reduce microbial resistance emergence.•AMPs promote animal growth, regulate gut microbiota, and improve disease resistance.•Weak activity and stability, and low yield are limitations for AMPs application.•Development strategies like gene engineering may improve in-feed AMPs properties.
ArticleNumber 172150
Author Li, Dongyu
Kong, Qing
Liu, Zhemin
Liang, Ziyu
Zhu, Changliang
Liang, Qingping
Mou, Haijin
Author_xml – sequence: 1
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  surname: Liang
  fullname: Liang, Qingping
  organization: College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China
– sequence: 2
  givenname: Zhemin
  surname: Liu
  fullname: Liu, Zhemin
  organization: Fundamental Science R&D Center of Vazyme Biotech Co. Ltd., Nanjing 210000, China
– sequence: 3
  givenname: Ziyu
  surname: Liang
  fullname: Liang, Ziyu
  organization: Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
– sequence: 4
  givenname: Changliang
  surname: Zhu
  fullname: Zhu, Changliang
  organization: College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China
– sequence: 5
  givenname: Dongyu
  surname: Li
  fullname: Li, Dongyu
  organization: College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China
– sequence: 6
  givenname: Qing
  surname: Kong
  fullname: Kong, Qing
  organization: College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China
– sequence: 7
  givenname: Haijin
  surname: Mou
  fullname: Mou, Haijin
  email: mousun@ouc.edu.cn
  organization: College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38580107$$D View this record in MEDLINE/PubMed
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ISSN 0048-9697
1879-1026
IngestDate Thu Sep 04 16:52:05 EDT 2025
Fri Sep 05 07:25:48 EDT 2025
Thu Apr 03 07:08:44 EDT 2025
Thu Apr 24 22:52:15 EDT 2025
Tue Jul 01 05:16:14 EDT 2025
Sat Apr 12 15:20:33 EDT 2025
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Keywords Development strategies
Global health
Sequence modification
Optimization of structural parameters
Alternative to in-feed antibiotics
Antimicrobial peptides
Language English
License Copyright © 2024 Elsevier B.V. All rights reserved.
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PublicationTitle The Science of the total environment
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Publisher Elsevier B.V
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Snippet The use of in-feed antibiotics has been widely restricted due to the significant environmental pollution and food safety concerns they have caused....
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SubjectTerms Alternative to in-feed antibiotics
animal husbandry
Antimicrobial peptides
antimicrobial properties
Development strategies
environment
feed industry
fermentation
food safety
Global health
Optimization of structural parameters
pollution
Sequence modification
Title Development strategies and application of antimicrobial peptides as future alternatives to in-feed antibiotics
URI https://dx.doi.org/10.1016/j.scitotenv.2024.172150
https://www.ncbi.nlm.nih.gov/pubmed/38580107
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