Characterization of a phase 1 metabolite of mycophenolic acid produced by CYP3A4/5

• Published in: Therapeutic drug monitoring Vol. 26; no. 6; p. 600
• Main Authors: Picard, Nicolas, Cresteil, Thierry, Prémaud, Aurélie, Marquet, Pierre
• Format: Journal Article
• Language: English
• Published: United States 01.12.2004
• Subjects: Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System - metabolism; Dose-Response Relationship, Drug; Enzyme Inhibitors - pharmacology; Humans; Kidney Transplantation - physiology; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Mycophenolic Acid - blood; Mycophenolic Acid - metabolism; Mycophenolic Acid - pharmacology; Mycophenolic Acid - urine

To characterize a phase 1 metabolite of mycophenolic acid (MPA) and the human cytochrome P450 isoform(s) (CYP) involved in its formation. MPA metabolites were investigated in blood and urine samples from transplant patients under mycophenolate mofetil therapy (n = 5) as well as with in vitro incubat...