Rosmarinic acid alleviates ethanol-induced lipid accumulation by repressing fatty acid biosynthesis
Recent studies have demonstrated that rosmarinic acid is a valuable natural product for treatment of alcoholic liver disease. However, the mechanisms whereby rosmarinic acid improves alcoholic liver disease remain unclear. Here we performed experiments using a non-transformed mouse hepatocyte cell l...
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Published in | Food & function Vol. 11; no. 3; pp. 294 - 216 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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England
Royal Society of Chemistry
01.03.2020
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Abstract | Recent studies have demonstrated that rosmarinic acid is a valuable natural product for treatment of alcoholic liver disease. However, the mechanisms whereby rosmarinic acid improves alcoholic liver disease remain unclear. Here we performed experiments using a non-transformed mouse hepatocyte cell line (AML12). Oil-red O staining demonstrated that rosmarinic acid reduced ethanol-induced lipid accumulation. It was shown that rosmarinic acid prevented ethanol-induced elevation of the malondialdehyde level. We also found that rosmarinic acid inhibited ethanol-induced mRNA expression of tumor necrosis factor-α and interleukin 6. Metabolomics analysis revealed that rosmarinic acid ameliorated ethanol-induced fatty acid biosynthesis in the cytoplasm. In addition, palmitic acid was a candidate biomarker in cells exposed to ethanol or ethanol plus rosmarinic acid. Rosmarinic acid prevented the ethanol-induced increase in sorbitol that is a component of the polyol pathway. Moreover, we confirmed that rosmarinic acid attenuated ethanol-induced mRNA expression of fatty acid synthase, probably by modulating the AMPK/SREBP-1c pathway. Furthermore, rosmarinic acid prevented the ethanol-induced decrease in eight metabolites that are involved in mitochondrial metabolism, including glycine and succinic acid which are the components of carnitine synthesis. These results provide a crucial insight into the molecular mechanism of rosmarinic acid in alleviating ethanol-induced injury.
Rosmarinic acid ameliorates ethanol-induced lipid accumulation by reducing fatty acid biosynthesis and tumor necrosis factor-α. |
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AbstractList | Recent studies have demonstrated that rosmarinic acid is a valuable natural product for treatment of alcoholic liver disease. However, the mechanisms whereby rosmarinic acid improves alcoholic liver disease remain unclear. Here we performed experiments using a non-transformed mouse hepatocyte cell line (AML12). Oil-red O staining demonstrated that rosmarinic acid reduced ethanol-induced lipid accumulation. It was shown that rosmarinic acid prevented ethanol-induced elevation of the malondialdehyde level. We also found that rosmarinic acid inhibited ethanol-induced mRNA expression of tumor necrosis factor-α and interleukin 6. Metabolomics analysis revealed that rosmarinic acid ameliorated ethanol-induced fatty acid biosynthesis in the cytoplasm. In addition, palmitic acid was a candidate biomarker in cells exposed to ethanol or ethanol plus rosmarinic acid. Rosmarinic acid prevented the ethanol-induced increase in sorbitol that is a component of the polyol pathway. Moreover, we confirmed that rosmarinic acid attenuated ethanol-induced mRNA expression of fatty acid synthase, probably by modulating the AMPK/SREBP-1c pathway. Furthermore, rosmarinic acid prevented the ethanol-induced decrease in eight metabolites that are involved in mitochondrial metabolism, including glycine and succinic acid which are the components of carnitine synthesis. These results provide a crucial insight into the molecular mechanism of rosmarinic acid in alleviating ethanol-induced injury. Recent studies have demonstrated that rosmarinic acid is a valuable natural product for treatment of alcoholic liver disease. However, the mechanisms whereby rosmarinic acid improves alcoholic liver disease remain unclear. Here we performed experiments using a non-transformed mouse hepatocyte cell line (AML12). Oil-red O staining demonstrated that rosmarinic acid reduced ethanol-induced lipid accumulation. It was shown that rosmarinic acid prevented ethanol-induced elevation of the malondialdehyde level. We also found that rosmarinic acid inhibited ethanol-induced mRNA expression of tumor necrosis factor-α and interleukin 6. Metabolomics analysis revealed that rosmarinic acid ameliorated ethanol-induced fatty acid biosynthesis in the cytoplasm. In addition, palmitic acid was a candidate biomarker in cells exposed to ethanol or ethanol plus rosmarinic acid. Rosmarinic acid prevented the ethanol-induced increase in sorbitol that is a component of the polyol pathway. Moreover, we confirmed that rosmarinic acid attenuated ethanol-induced mRNA expression of fatty acid synthase, probably by modulating the AMPK/SREBP-1c pathway. Furthermore, rosmarinic acid prevented the ethanol-induced decrease in eight metabolites that are involved in mitochondrial metabolism, including glycine and succinic acid which are the components of carnitine synthesis. These results provide a crucial insight into the molecular mechanism of rosmarinic acid in alleviating ethanol-induced injury. Rosmarinic acid ameliorates ethanol-induced lipid accumulation by reducing fatty acid biosynthesis and tumor necrosis factor-α. |
Author | Shangguan, Yu Guo, Chang Yang, Jian Ruan, Yanxin Xue, Guoqing Ma, Jingfan Qiu, Longxin Zhang, Meiru |
AuthorAffiliation | Key Laboratory of Preventive Veterinary Medicine and Biotechnology (Longyan University) Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology Fujian Province University School of Life Sciences Longyan University |
AuthorAffiliation_xml | – name: Longyan University – name: Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology – name: Key Laboratory of Preventive Veterinary Medicine and Biotechnology (Longyan University) – name: School of Life Sciences – name: Fujian Province University |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32129352$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Accumulation Animals Biomarkers Biosynthesis Carnitine Cell Line Cinnamates - pharmacology Cytoplasm Depsides - pharmacology Ethanol Ethanol - pharmacology Fatty acids Fatty Acids - biosynthesis Fatty-acid synthase Gene expression Glycine Hepatocytes - drug effects Hepatocytes - metabolism Interleukin 6 Lipid Metabolism Lipids Liver Liver diseases Malondialdehyde Medical treatment Metabolism Metabolites Metabolomics Mice Mitochondria Natural products Palmitic acid Rosmarinic Acid Sorbitol Sterol regulatory element-binding protein Stress, Physiological Succinic acid Tumor necrosis factor-α |
Title | Rosmarinic acid alleviates ethanol-induced lipid accumulation by repressing fatty acid biosynthesis |
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