Morphological and Ultrastructural Features of Human Islet Grafts Performed in Diabetic Nude Mice

• Published in: Ultrastructural pathology Vol. 29; no. 6; pp. 525 - 533
• Main Authors: Finzi, Giovanna, Davalli, Alberto, Placidi, Claudia, Usellini, Luciana, La Rosa, Stefano, Folli, Franco, Capella, Carlo
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.11.2005; Taylor & Francis
• Subjects: Animals; Diabetes Mellitus, Experimental - surgery; Graft Rejection - pathology; Humans; islet transplantation; Islets of Langerhans - ultrastructure; Islets of Langerhans Transplantation; Mice; Mice, Nude; Microscopy, Electron, Transmission; type 1 diabetes; β cells degeneration

Islet transplantation is a new therapeutic approach to type 1 diabetes mellitus. However, in several patients insulin levels are not restored and the glycemic control is inadequate. To clarify the cause of graft failure, the authors investigated with light and electron microscopy some human islet gr...