Postnatal exposure to DINP was associated with greater alterations of lipidomic markers for hepatic steatosis than DEHP in postweaning mice

• Published in: The Science of the total environment Vol. 758; p. 143631
• Main Authors: Yang, Yan, Sun, Fengjiang, Chen, Haojia, Tan, Hongli, Yang, Liu, Zhang, Long, Xie, Jinxin, Sun, Jiachen, Huang, Xiaochen, Huang, Yichao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2021
• Subjects: Animals; blood lipids; body weight; ceramides; cholesterol; di(2-ethylhexyl) phthalate; di-isononyl phthalate; Diethylhexyl Phthalate - toxicity; endocrine-disrupting chemicals; environment; fatty liver; Fatty Liver - chemically induced; Female; females; glycerol; lactation; Lipid metabolism; Lipidomics; Liver; Male; Mice; phosphates; phosphatidylethanolamines; phthalates; Phthalic Acids - toxicity; Steatosis; toxicity; triacylglycerols; di-isononyl phthalate; Lipidomics; di(2-ethylhexyl) phthalate; Lipid metabolism; Liver; Steatosis

The toxicity of the endocrine disruptor di(2-ethylhexyl) phthalate (DEHP) has been extensively studied for its hormonal dysregulation, obesogenic effect and associated metabolic diseases. DEHP's primary substitute di-isononyl phthalate (DINP), however, although increased in annual production gl...