CD4-imitating human antibodies in HIV infection and anti-idiotypic vaccination

• Published in: The Journal of immunology (1950) Vol. 156; no. 2; pp. 826 - 833
• Main Authors: Deckert, PM, Ballmaier, M, Lang, S, Deicher, H, Schedel, I
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.01.1996
• Subjects: Adult; AIDS/HIV; Animals; Antibodies, Anti-Idiotypic - blood; Antibodies, Anti-Idiotypic - immunology; Antibodies, Anti-Idiotypic - therapeutic use; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - therapeutic use; Antibody Specificity; CD4 Antigens - immunology; Cross Reactions; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; HIV Envelope Protein gp120 - immunology; HIV Infections - blood; HIV Infections - immunology; HIV Infections - therapy; HIV-1 - immunology; human immunodeficiency virus; Humans; Immunotherapy, Active; Male; Mice; Middle Aged; Molecular Mimicry; Rabbits; Recombinant Proteins - immunology; Vaccination

Anti-idiotypic vaccination against HIV infection aims at inducing an anti-gp120 immune response through anti-CD4 Abs mimicking epitopes of the gp120 molecule. The mAb IOT4a induces anti-gp120 Abs in rabbits. This study investigates the presence of human serum Abs cross-reacting with anti-CD4 mAbs an...