Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes

• Published in: The Journal of immunology (1950) Vol. 180; no. 7; pp. 5092 - 5100
• Main Authors: Perez, Carina L, Larsen, Mette V, Gustafsson, Rasmus, Norstrom, Melissa M, Atlas, Ann, Nixon, Douglas F, Nielsen, Morten, Lund, Ole, Karlsson, Annika C
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.04.2008
• Subjects: Amino Acid Sequence; Epitopes, T-Lymphocyte - chemistry; Epitopes, T-Lymphocyte - immunology; Histocompatibility Antigens Class I - immunology; HIV Infections - classification; HIV Infections - epidemiology; HIV Infections - immunology; HIV-1 - classification; HIV-1 - immunology; Human immunodeficiency virus 1; Humans; Molecular Sequence Data; T-Lymphocytes, Cytotoxic - immunology

The genetic variations of the HIV-1 virus and its human host constitute major obstacles for obtaining potent HIV-1-specific CTL responses in individuals of diverse ethnic backgrounds infected with different HIV-1 variants. In this study, we developed and used a novel algorithm to select 184 predicte...