Terpenoids from the Chinese liverwort Heteroscyphus coalitus and their anti-virulence activity against Candida albicans

• Published in: Phytochemistry (Oxford) Vol. 174; pp. 112324 - 112334
• Main Authors: Wang, Xue, Jin, Xue-Yang, Zhou, Jin-Chuan, Zhu, Rong-Xiu, Qiao, Ya-Nan, Zhang, Jiao-Zhen, Li, Yi, Zhang, Chun-Yang, Chen, Wang, Chang, Wen-Qiang, Lou, Hong-Xiang
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.06.2020; Elsevier
• Subjects: acids; active ingredients; Anti-virulence; Biochemistry & Molecular Biology; biofilm; Candida albicans; circular dichroism spectroscopy; Diterpenes, Clerodane; fungi; genes; Geocalycaceae; Hepatophyta; Heteroscyphus coalitus (Hook.) Schiffner; hyphae; labdane; Life Sciences & Biomedicine; Liverwort; mosses and liverworts; nuclear magnetic resonance spectroscopy; Plant Sciences; Science & Technology; Sesquiterpenes; sesquiterpenoids; Terpenes; Terpenoids; transcription (genetics); X-ray diffraction; Candida albicans; Geocalycaceae; Anti-virulence; Liverwort; Heteroscyphus coalitus (Hook.) Schiffner; Terpenoids; BRYOPHYTES; DITERPENOIDS; CONSTITUENTS

In this study, 14 previously undescribed terpenoids were isolated from the Chinese liverwort Heteroscyphus coalitus (Hook.) Schiffner, including a rare harziane type diterpenoid, heteroscyphsic acid A; eight ent-clerodane diterpenoids, heteroscyphsic acids B–I; four labdane diterpenoids, heteroscyph...