Normal distribution of presenilin-1 and nicastrin in skeletal muscle and the differential responses of these proteins after denervation

• Published in: Biochimica et biophysica acta Vol. 1760; no. 6; pp. 980 - 987
• Main Authors: Sakuma, Kunihiro, Nakao, Ryuta, Yamasa, Yuka, Yasuhara, Masahiro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2006
• Subjects: Amyloid Precursor Protein Secretases; Animals; Cell Membrane - metabolism; Cell Nucleus - metabolism; Denervation; Male; Membrane Glycoproteins - genetics; Membrane Glycoproteins - immunology; Membrane Glycoproteins - metabolism; Membrane Proteins - genetics; Membrane Proteins - immunology; Membrane Proteins - metabolism; Muscle Denervation; Muscle, Skeletal - cytology; Muscle, Skeletal - innervation; Muscle, Skeletal - metabolism; Myonucleus; Nicastrin; Presenilin-1; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; RNA, Messenger - metabolism; Skeletal muscle; Presenilin-1; Nicastrin; Myonucleus; Skeletal muscle; Denervation

Presenilin-1 and nicastrin, two components of γ-secretase associated with Alzheimer's disease plaques, are present in the synapses of the brain and in various peripheral organs, including skeletal muscle. In the present study, we examined the expression pattern of presenilin-1 and nicastrin in...