Effect of functional nuclear factor-kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma

• Published in: Annals of oncology Vol. 25; no. 12; pp. 2413 - 2419
• Main Authors: Zhang, Q., Ji, X.W., Hou, X.M., Lu, F.M., Du, Y., Yin, J.H., Sun, X.Y., Deng, Y., Zhao, J., Han, X., Yang, G.S., Zhang, H.W., Chen, X.M., Shen, H.B., Wang, H.Y., Cao, G.W.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.12.2014; Oxford University Press
• Subjects: Antineoplastic agents; Biological and medical sciences; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - virology; Gastroenterology. Liver. Pancreas. Abdomen; Genetic Predisposition to Disease; Hepatitis B virus; Hepatitis B virus - genetics; hepatocellular carcinoma; Humans; Infectious diseases; interaction; Liver Neoplasms - genetics; Liver Neoplasms - virology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Mutation; NF-kappa B - genetics; NF-κB; Pharmacology. Drug treatments; polymorphism; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Tumors; Viral diseases; viral mutation; interaction; NF-κB; viral mutation; polymorphism; hepatitis B virus; hepatocellular carcinoma; Genetic variability; Interaction; Orthohepadnavirus; Hepatic disease; Hepatocellular carcinoma; Genotype; Malignant tumor; Infection; Virus; Persistence; Liver cancer; Hepadnaviridae; Viral disease; Risk factor; Digestive diseases; Genetics; Transcription factor NFκB; Mutation; Hepatitis B virus; Transcription factor; Cancer; Polymorphism

Nonresolving inflammation and viral mutations are important in hepatitis B virus (HBV)-induced hepatocarcinogenesis. However, the effects of genetic polymorphisms affecting nuclear factor-kappaB (NF-κB) on HBV persistence and generation of hepatocellular carcinoma (HCC)-related HBV mutations remain...