Increased therapeutic efficiency of a lipid-soluble alkylating agent incorporated in liposomes
A highly hydrophobic alkylating agent, 1-N,N-bis(beta-bromoethyl) amino-3-methylnaphthalene, given as the free drug in oil, cured a substantial proportion of mice bearing the PC6 myeloma in the dose range 2-7 mg/kg. However, these doses were toxic, and the LD50 was 6-7 mg/kg. When incorporated in li...
Saved in:
| Published in | British journal of cancer Vol. 45; no. 6; pp. 830 - 834 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
Nature Publishing Group
01.06.1982
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | A highly hydrophobic alkylating agent, 1-N,N-bis(beta-bromoethyl) amino-3-methylnaphthalene, given as the free drug in oil, cured a substantial proportion of mice bearing the PC6 myeloma in the dose range 2-7 mg/kg. However, these doses were toxic, and the LD50 was 6-7 mg/kg. When incorporated in liposomes, similar curative effects were obtained at doses of 10-41 mg/kg without material toxicity, even at the highest dose. Liposome entrapment therefore greatly increases the therapeutic efficiency of this agent. |
|---|---|
| AbstractList | A highly hydrophobic alkylating agent, 1-N,N-bis(beta-bromoethyl) amino-3-methylnaphthalene, given as the free drug in oil, cured a substantial proportion of mice bearing the PC6 myeloma in the dose range 2-7 mg/kg. However, these doses were toxic, and the LD50 was 6-7 mg/kg. When incorporated in liposomes, similar curative effects were obtained at doses of 10-41 mg/kg without material toxicity, even at the highest dose. Liposome entrapment therefore greatly increases the therapeutic efficiency of this agent. |
| Author | Babbage, J W Berenbaum, M C |
| Author_xml | – sequence: 1 givenname: J W surname: Babbage fullname: Babbage, J W – sequence: 2 givenname: M C surname: Berenbaum fullname: Berenbaum, M C |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/7093119$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVkE1LxDAQhoMoun7cvAr5AXbNJO02uQgifoHgRa-GNJ2u0W5Skq6w_96UlUVPQ3jfPDM8x2TfB4-EnAObAxPyqvm0c1CSz0GUe2QGleAFSF7vkxljrC6Y4uyIHKf0mZ-KyfqQHNZMCQA1I-9P3kY0CVs6fmA0A65HZyl2nbMOvd3Q0FFDeze4tkihXzc9UtN_bXozOr-kZol-pM7bEIcQzZg5zk_1kMIK0yk56Eyf8Ox3npC3-7vX28fi-eXh6fbmubAlK8eilbVqZQvYcQtGCVVxUfEOqqaqSkAlmQDVcMHEolSyZBwX0JTQLVSt5KJpxAm53nKHdbPC1uajoun1EN3KxI0Oxun_iXcfehm-NWcArBQZcLkF2BhSitjt_gLTk2adNetJs86ac_3i775d-ddrzuk292ZcR9zlGTIxJsQPNO2G9A |
| CitedBy_id | crossref_primary_10_1016_0006_2952_83_90289_7 crossref_primary_10_1016_0169_409X_89_90029_X crossref_primary_10_3109_02652048609031561 crossref_primary_10_1016_0277_5379_84_90096_8 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 5PM |
| DOI | 10.1038/bjc.1982.134 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1532-1827 |
| EndPage | 834 |
| ExternalDocumentID | 10_1038_bjc_1982_134 7093119 bjc1982134 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GroupedDBID | - -Q- 02 08R 0R 23N 39C 3V. 4.4 53G 55 5GY 5RE 70F 7RV 7X7 88E 8AO 8C1 8FI 8FJ 8R4 8R5 8WZ A6W AADWK AAPBV AAWBL AAWTL AAYJO AAZLF ABAWZ ABDBF ABDEU ABFLS ABGIJ ABOCM ABPTK ABUWG ACGFS ACKTT ACPRK ADACO ADBBV ADBIT ADHDB ADQMX AEDAW AEJRE AENEX AEXYK AFKRA AFRAH AFSHS AGEZK AHMBA AHSBF AJRNO ALFFA ALMA_UNASSIGNED_HOLDINGS AN0 ASPBG AVWKF AXYYD AZFZN B0M BAWUL BBAFP BBNVY BENPR BHPHI BKEYQ BKKNO BNQBC BPHCQ BVXVI CAG COF CS3 DIK DU5 E3Z EAD EAP EAS EBC EBD EBLON EBS EE. EIOEI EJD EMB EMK EPL ESX EX3 F5P FDQFY FEDTE FERAY FIZPM FRJ FSGXE FYUFA GJ GX1 HCIFZ HVGLF HYE HZ IH2 J5H JSO KQ8 M1P M41 M7P NAO NAPCQ O9- OK1 P2P PQEST PQQKQ PQUKI PRINS PROAC PSQYO Q- Q2X RIG RNT RNTTT RPM SNX SNYQT SV3 SWTZT TAOOD TBHMF TDRGL TR2 TUS UDS VH1 W2D WH7 WOW X7M XFK Y6R ZA5 ZGI --- .55 .GJ 0R~ 36B 406 6J9 AACDK AANZL AASML AATNV AAYZH ABAKF ABLJU ABZZP ACAOD ACGFO ACRQY ACZOJ ADFRT AEFQL AEMSY AEVLU AFBBN AGAYW AGHAI AGQEE AI. AIGIU AILAN AMYLF AOIJS CCPQU CGR CUY CVF DNIVK DPUIP ECM EIF EMOBN FIGPU HMCUK HZ~ IWAJR JZLTJ NPM NQJWS SOHCF SRMVM UKHRP ~02 ~8M AAYXX CITATION 5PM |
| ID | FETCH-LOGICAL-c404t-d879d8d1ef2c1a93952352f15b5541e980319b23036498402e61b41f697986bb3 |
| IEDL.DBID | RPM |
| ISSN | 0007-0920 |
| IngestDate | Tue Sep 17 21:27:22 EDT 2024 Fri Aug 23 02:26:27 EDT 2024 Wed Oct 16 00:51:54 EDT 2024 Thu Oct 07 19:38:29 EDT 2021 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| License | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c404t-d879d8d1ef2c1a93952352f15b5541e980319b23036498402e61b41f697986bb3 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011043/ |
| PMID | 7093119 |
| PageCount | 5 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2011043 crossref_primary_10_1038_bjc_1982_134 pubmed_primary_7093119 nature_primary_bjc1982134 |
| ProviderPackageCode | ABDEU AEDAW AAZLF -Q- AADWK AAYJO 70F ADQMX EE. RNTTT SWTZT ABGIJ RNT NAO |
| PublicationCentury | 1900 |
| PublicationDate | 19820601 |
| PublicationDateYYYYMMDD | 1982-06-01 |
| PublicationDate_xml | – month: 6 year: 1982 text: 19820601 day: 1 |
| PublicationDecade | 1980 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | British journal of cancer |
| PublicationTitleAlternate | Br J Cancer |
| PublicationYear | 1982 |
| Publisher | Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group |
| SSID | ssj0009087 |
| Score | 1.30897 |
| Snippet | A highly hydrophobic alkylating agent, 1-N,N-bis(beta-bromoethyl) amino-3-methylnaphthalene, given as the free drug in oil, cured a substantial proportion of... |
| SourceID | pubmedcentral crossref pubmed nature |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 830 |
| SubjectTerms | 1-Naphthylamine - analogs & derivatives 1-Naphthylamine - therapeutic use 1-Naphthylamine - toxicity Alkylating Agents - therapeutic use Alkylating Agents - toxicity Animals Dose-Response Relationship, Drug Liposomes - administration & dosage Male Mice Mice, Inbred BALB C Multiple Myeloma - drug therapy Naphthalenes - therapeutic use Neoplasms, Experimental - drug therapy Oils - administration & dosage |
| Title | Increased therapeutic efficiency of a lipid-soluble alkylating agent incorporated in liposomes |
| URI | http://dx.doi.org/10.1038/bjc.1982.134 https://www.ncbi.nlm.nih.gov/pubmed/7093119 https://pubmed.ncbi.nlm.nih.gov/PMC2011043 |
| Volume | 45 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LTuswEB0BEogN4inKS15wl2kT203sJUIgHipicZFYEdmJc2-gTStaFvw9M85D7Zb12JF1PNbM2GdOAC4N9Z6JTAShMHEgncQzxzMXyDyxnIdGca_ENHqK717kw-vwdQ2GbS-MJ-1ntuxX40m_Kv97buVskg1antjgeXTtg5YUg3VYRwdtS_RWaTdUtVAm3cFpHjZs91CogX3P-lhk834k5DZsJljNRySxsxSROj3NLh6tciWXgs_tLuw0WSO7qle3B2uu2oetUfMufgBveMyJXe5yttRQxZzXh6DmSjYtmGHjclbmAXmbHTtmxh_fxISr_jFDDVaMhBpqXWP8TlnR8Ol8OnHzQ3i5vfl7fRc0f04IMhnKRZCrROcqj1zBs8hoobHcHPIiGlrMHiKnFfUuWU7hS2os8biLIyujItaJVrG14gg2qmnljoHxQhVJJjDPwGheFMLQHKNl7HSYYzrTgz8teumsFshI_cO2UCninRLeKeLdg14NbTcKrWT0tqMa5M7WbE0PkhX0OzuJYq9a0Fe8OHbjGye_nnkK27Ssmg52BhuLzy93jonHwl5gyn3_eOHd7Qd4o9fM |
| link.rule.ids | 230,315,730,783,787,888,27936,27937,53804,53806 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB2VIqAXviuWFvABjskmtjexj1VFtUC34tCinohsxymhu9kV3R7g1zPjfGiXWzk_O3L0nMxM_OYF4L2h3jPhRJQIk0XSS3zmuPORLHPLeWIUD05Ms7NseiE_X04ud2DS98IE0b6zddzMF3FT_wjaytXCjXud2Pjr7DgELSnG9-A-Pq-J7Iv03ms3Ua1VJn2F0zzp9O6JUGP708VYZvM4FXIPHuRYz6dksrMRkwZHzSEibaslN8LPyRP41i-8VZ1cx7drG7s__3g63vnOnsLjLiFlRy38DHZ88xwezroj9xfwHd8gJFz3Jdvo1WI-WE9Q3yZbVsyweb2qy4g2sp17ZubXv0lk11wxQ71bjDwgWstkvE7d0PDlzXLhb17CxcnH8-Np1P2UIXIykeuoVLkuVZn6irvUaKGxkp3wKp1YTExSrxW1RVlOkVFqrB65z1Ir0yrTuVaZtWIfdptl418B45WqcicwhcFEoaqEoTlGy8zrpMRMaQQfelqKVeu9UYQzc6EKJLIgIgskcgSjlrNhFKIEBmy_ZW_AOs5HkG_ROuDkt72NIFnBd7sj5_V_z3wHj6bns9Pi9NPZlwPYoyW2qrND2F3_uvVvML9Z27dhN_8FylH4tA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VVlS9QHlUbAvFBzjmZXsT-4haVm1hqx6oVHEgsh0bQnezq3Z7gF_P2Hlol2PPM44cfXZmJv7mM8AH5XvPmGFRylQecctxz1FjI14VmtJUCRqUmKaX-dk1v7gZ36xd9RVI-0bXcTObx039K3Arl3OT9Dyx5Gp6EoIWZ8mycskT2ME9m-Z9od7r7aailcv0f-IkTTvOe8pEon-bGEttGmeM78HTAmv6zAvtrMWlQVVziEqbjMm1EDR5Dt_7ybfMk9v4YaVj8_c_XcdHvd0-POsSU_KpdXkBW7Z5CbvT7uj9FfzAL4knsNuKrPVsERskKHz_Jlk4osisXtZV5Be0nlmiZrd_PNmu-UmU7-EiXguilU7G59SNd1_cL-b2_jVcTz5_OzmLussZIsNTvooqUchKVJl11GRKMokV7Zi6bKwxQcmsFL49SlMfIbnEKpLaPNM8c7kspMi1Zgew3Swa-wYIdcIVhmEqgwmDc0z5MUry3Mq0woxpBB97aMplq8FRhrNzJkoEs_RglgjmCEYtboMXWr0x2A5aBAdbh_sIig1oB7vX3d60IGBBf7sD6PDRI9_D7tXppPx6fvnlCPb8DFvy2VvYXt092HeY5qz0cVjQ_wCoDvs0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Increased+therapeutic+efficiency+of+a+lipid-soluble+alkylating+agent+incorporated+in+liposomes&rft.jtitle=British+journal+of+cancer&rft.au=Babbage%2C+J.+W.&rft.au=Berenbaum%2C+M.+C.&rft.date=1982-06-01&rft.pub=Nature+Publishing+Group&rft.issn=0007-0920&rft.eissn=1532-1827&rft.volume=45&rft.issue=6&rft.spage=830&rft.epage=834&rft_id=info:doi/10.1038%2Fbjc.1982.134&rft_id=info%3Apmid%2F7093119&rft.externalDBID=PMC2011043 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0007-0920&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0007-0920&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0007-0920&client=summon |