Antiulcer and antiproliferative properties of spent brewer's yeast peptide extracts for incorporation into foods

• Published in: Food & function Vol. 7; no. 5; pp. 2331 - 2337
• Main Authors: Amorim, Maria M, Pereira, Joana O, Monteiro, Karin M, Ruiz, Ana L, Carvalho, João E, Pinheiro, Hélder, Pintado, Manuela
• Format: Journal Article
• Language: English
• Published: England 18.05.2016
• Subjects: Administration, Oral; animal models; Animals; Anti-Ulcer Agents - chemistry; Anti-Ulcer Agents - isolation & purification; Anti-Ulcer Agents - pharmacology; brewers yeast; Cell Line, Tumor; Cell Proliferation - drug effects; Cercopithecus aethiops; ethanol; Ethanol - adverse effects; filtration; Functional Food; functional foods; Fungal Proteins - administration & dosage; Fungal Proteins - pharmacology; gastric mucosa; Gastric Mucosa - drug effects; Gastric Mucosa - injuries; Gastric Mucosa - pathology; HT29 Cells; human cell lines; Humans; Hydrolysis; Leukemia; Male; MCF-7 Cells; Models, Animal; Nitric Oxide - pharmacology; oral administration; peptides; Peptides - administration & dosage; Peptides - pharmacology; Prostaglandins - pharmacology; proteins; Rats; Rats, Wistar; Saccharomyces cerevisiae; Saccharomyces cerevisiae - chemistry; Stomach Ulcer - chemically induced; Stomach Ulcer - drug therapy; Stomach Ulcer - pathology; value added; Vero Cells

The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. Peptide concentrates were obtained by hydrolysis of spent brewer's yeast proteins followed by a filtration process. In order to prove the possi...