Antiulcer and antiproliferative properties of spent brewer's yeast peptide extracts for incorporation into foods
The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. Peptide concentrates were obtained by hydrolysis of spent brewer's yeast proteins followed by a filtration process. In order to prove the possi...
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| Published in | Food & function Vol. 7; no. 5; pp. 2331 - 2337 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
18.05.2016
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. Peptide concentrates were obtained by hydrolysis of spent brewer's yeast proteins followed by a filtration process. In order to prove the possible protection of gastric mucosa, an animal model with ulcerative lesions caused by oral administration of absolute ethanol was used. The peptide fraction <3 kDa was able to reduce gastric injuries to significant levels (
p
< 0.001) and the effective dose (DE
50
) was 816 mg per kg bw. The cytoprotective effect appears to depend on a prostaglandin-mediated mechanism and also on a nonspecific mechanism. The antiproliferative activity of the extract in nine different human tumoral cell lines was tested. The results exhibited a promising antiproliferative activity against the cell line K-562 (leukemia). The results suggest that a new peptide extract can be used to develop new value-added functional food products, although further studies are required.
The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. |
|---|---|
| AbstractList | The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. Peptide concentrates were obtained by hydrolysis of spent brewer's yeast proteins followed by a filtration process. In order to prove the possible protection of gastric mucosa, an animal model with ulcerative lesions caused by oral administration of absolute ethanol was used. The peptide fraction <3 kDa was able to reduce gastric injuries to significant levels (
p
< 0.001) and the effective dose (DE
50
) was 816 mg per kg bw. The cytoprotective effect appears to depend on a prostaglandin-mediated mechanism and also on a nonspecific mechanism. The antiproliferative activity of the extract in nine different human tumoral cell lines was tested. The results exhibited a promising antiproliferative activity against the cell line K-562 (leukemia). The results suggest that a new peptide extract can be used to develop new value-added functional food products, although further studies are required.
The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. Peptide concentrates were obtained by hydrolysis of spent brewer's yeast proteins followed by a filtration process. In order to prove the possible protection of gastric mucosa, an animal model with ulcerative lesions caused by oral administration of absolute ethanol was used. The peptide fraction <3 kDa was able to reduce gastric injuries to significant levels (p < 0.001) and the effective dose (DE50) was 816 mg per kg bw. The cytoprotective effect appears to depend on a prostaglandin-mediated mechanism and also on a nonspecific mechanism. The antiproliferative activity of the extract in nine different human tumoral cell lines was tested. The results exhibited a promising antiproliferative activity against the cell line K-562 (leukemia). The results suggest that a new peptide extract can be used to develop new value-added functional food products, although further studies are required.The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. Peptide concentrates were obtained by hydrolysis of spent brewer's yeast proteins followed by a filtration process. In order to prove the possible protection of gastric mucosa, an animal model with ulcerative lesions caused by oral administration of absolute ethanol was used. The peptide fraction <3 kDa was able to reduce gastric injuries to significant levels (p < 0.001) and the effective dose (DE50) was 816 mg per kg bw. The cytoprotective effect appears to depend on a prostaglandin-mediated mechanism and also on a nonspecific mechanism. The antiproliferative activity of the extract in nine different human tumoral cell lines was tested. The results exhibited a promising antiproliferative activity against the cell line K-562 (leukemia). The results suggest that a new peptide extract can be used to develop new value-added functional food products, although further studies are required. The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. Peptide concentrates were obtained by hydrolysis of spent brewer's yeast proteins followed by a filtration process. In order to prove the possible protection of gastric mucosa, an animal model with ulcerative lesions caused by oral administration of absolute ethanol was used. The peptide fraction <3 kDa was able to reduce gastric injuries to significant levels ( p < 0.001) and the effective dose (DE 50 ) was 816 mg per kg bw. The cytoprotective effect appears to depend on a prostaglandin-mediated mechanism and also on a nonspecific mechanism. The antiproliferative activity of the extract in nine different human tumoral cell lines was tested. The results exhibited a promising antiproliferative activity against the cell line K-562 (leukemia). The results suggest that a new peptide extract can be used to develop new value-added functional food products, although further studies are required. The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. Peptide concentrates were obtained by hydrolysis of spent brewer's yeast proteins followed by a filtration process. In order to prove the possible protection of gastric mucosa, an animal model with ulcerative lesions caused by oral administration of absolute ethanol was used. The peptide fraction <3 kDa was able to reduce gastric injuries to significant levels (p< 0.001) and the effective dose (DE sub(50)) was 816 mg per kg bw. The cytoprotective effect appears to depend on a prostaglandin-mediated mechanism and also on a nonspecific mechanism. The antiproliferative activity of the extract in nine different human tumoral cell lines was tested. The results exhibited a promising antiproliferative activity against the cell line K-562 (leukemia). The results suggest that a new peptide extract can be used to develop new value-added functional food products, although further studies are required. The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. Peptide concentrates were obtained by hydrolysis of spent brewer's yeast proteins followed by a filtration process. In order to prove the possible protection of gastric mucosa, an animal model with ulcerative lesions caused by oral administration of absolute ethanol was used. The peptide fraction <3 kDa was able to reduce gastric injuries to significant levels (p < 0.001) and the effective dose (DE50) was 816 mg per kg bw. The cytoprotective effect appears to depend on a prostaglandin-mediated mechanism and also on a nonspecific mechanism. The antiproliferative activity of the extract in nine different human tumoral cell lines was tested. The results exhibited a promising antiproliferative activity against the cell line K-562 (leukemia). The results suggest that a new peptide extract can be used to develop new value-added functional food products, although further studies are required. The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. Peptide concentrates were obtained by hydrolysis of spent brewer's yeast proteins followed by a filtration process. In order to prove the possible protection of gastric mucosa, an animal model with ulcerative lesions caused by oral administration of absolute ethanol was used. The peptide fraction <3 kDa was able to reduce gastric injuries to significant levels (p < 0.001) and the effective dose (DE₅₀) was 816 mg per kg bw. The cytoprotective effect appears to depend on a prostaglandin-mediated mechanism and also on a nonspecific mechanism. The antiproliferative activity of the extract in nine different human tumoral cell lines was tested. The results exhibited a promising antiproliferative activity against the cell line K-562 (leukemia). The results suggest that a new peptide extract can be used to develop new value-added functional food products, although further studies are required. |
| Author | Carvalho, João E Pinheiro, Hélder Amorim, Maria M Monteiro, Karin M Pereira, Joana O Pintado, Manuela Ruiz, Ana L |
| AuthorAffiliation | Divisão de Farmacologia e Toxicologia Faculdade de Ciências Médicas Rua Tessália Vieira de Camargo Escola Superior de Biotecnologia Universidade Católica Portuguesa/Porto Departamento de Farmacologia e Terapêutica da Faculdade de Medicina da Universidade do Porto Departamento de Clínica Médica Centro Pluridisciplinar de Pesquisas Químicas CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado Biológicas e Agrícolas (CPQBA) Faculdade de Ciências Farmacêuticas UNICAMP Universidade Estadual de Campinas |
| AuthorAffiliation_xml | – sequence: 0 name: Divisão de Farmacologia e Toxicologia – sequence: 0 name: Departamento de Farmacologia e Terapêutica da Faculdade de Medicina da Universidade do Porto – sequence: 0 name: Faculdade de Ciências Médicas – sequence: 0 name: Universidade Católica Portuguesa/Porto – sequence: 0 name: Escola Superior de Biotecnologia – sequence: 0 name: CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado – sequence: 0 name: Centro Pluridisciplinar de Pesquisas Químicas – sequence: 0 name: UNICAMP – sequence: 0 name: Rua Tessália Vieira de Camargo – sequence: 0 name: Faculdade de Ciências Farmacêuticas – sequence: 0 name: Biológicas e Agrícolas (CPQBA) – sequence: 0 name: Departamento de Clínica Médica – sequence: 0 name: Universidade Estadual de Campinas |
| Author_xml | – sequence: 1 givenname: Maria M surname: Amorim fullname: Amorim, Maria M – sequence: 2 givenname: Joana O surname: Pereira fullname: Pereira, Joana O – sequence: 3 givenname: Karin M surname: Monteiro fullname: Monteiro, Karin M – sequence: 4 givenname: Ana L surname: Ruiz fullname: Ruiz, Ana L – sequence: 5 givenname: João E surname: Carvalho fullname: Carvalho, João E – sequence: 6 givenname: Hélder surname: Pinheiro fullname: Pinheiro, Hélder – sequence: 7 givenname: Manuela surname: Pintado fullname: Pintado, Manuela |
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| Snippet | The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods. Peptide... |
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| SubjectTerms | Administration, Oral animal models Animals Anti-Ulcer Agents - chemistry Anti-Ulcer Agents - isolation & purification Anti-Ulcer Agents - pharmacology brewers yeast Cell Line, Tumor Cell Proliferation - drug effects Cercopithecus aethiops ethanol Ethanol - adverse effects filtration Functional Food functional foods Fungal Proteins - administration & dosage Fungal Proteins - pharmacology gastric mucosa Gastric Mucosa - drug effects Gastric Mucosa - injuries Gastric Mucosa - pathology HT29 Cells human cell lines Humans Hydrolysis Leukemia Male MCF-7 Cells Models, Animal Nitric Oxide - pharmacology oral administration peptides Peptides - administration & dosage Peptides - pharmacology Prostaglandins - pharmacology proteins Rats Rats, Wistar Saccharomyces cerevisiae Saccharomyces cerevisiae - chemistry Stomach Ulcer - chemically induced Stomach Ulcer - drug therapy Stomach Ulcer - pathology value added Vero Cells |
| Title | Antiulcer and antiproliferative properties of spent brewer's yeast peptide extracts for incorporation into foods |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27125503 https://www.proquest.com/docview/1790458983 https://www.proquest.com/docview/1794500834 https://www.proquest.com/docview/2253243454 |
| Volume | 7 |
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