The urinary metabolic profile of diethylene glycol methyl ether and triethylene glycol methyl ether in Sprague-Dawley rats and the role of the metabolite methoxyacetic acid in their toxicity

• Published in: Regulatory toxicology and pharmacology Vol. 110; p. 104512
• Main Authors: Kelsey, Jeffrey R., Cnubben, Nicole H.P., Bogaards, Jan J.P., Braakman, René B.H., van Stee, Leo L.P., Smet, Karen
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.02.2020
• Subjects: 2-(2-(2-methoxyethoxy)ethoxy)ethanol; 2-(2-methoxyethoxy)ethanol; 2-Methoxyacetic acid; DEGME; Glycol ethers; Metabolism; TEGME; DEGME; Glycol ethers; 2-(2-methoxyethoxy)ethanol; 2-Methoxyacetic acid; Metabolism; 2-(2-(2-methoxyethoxy)ethoxy)ethanol; TEGME

Ethylene glycol ethers are a well-known series of solvents and hydraulic fluids derived from the reaction of ethylene oxide and monoalcohols. Use of methanol as the alcohol results in a series of mono, di and triethylene glycol methyl ethers. The first in the series, monoethylene glycol methyl ether...