Administration of the Hyper-immune Bovine Colostrum Extract IMM-124E Ameliorates Experimental Murine Colitis

• Published in: Journal of Crohn's and colitis Vol. 13; no. 6; pp. 785 - 797
• Main Authors: Spalinger, Marianne R, Atrott, Kirstin, Baebler, Katharina, Schwarzfischer, Marlene, Melhem, Hassan, Peres, Dan R, Lalazar, Gadi, Rogler, Gerhard, Scharl, Michael, Frey-Wagner, Isabelle
• Format: Journal Article
• Language: English
• Published: England 27.05.2019
• Subjects: Animals; Blotting, Western; Cattle; Colitis - drug therapy; Colitis - pathology; Colon - pathology; Colostrum - chemistry; Colostrum - immunology; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunoglobulin G - immunology; Immunoglobulin G - therapeutic use; Lipopolysaccharides - immunology; Mice; Mice, Inbred C57BL; Peroxidase - metabolism; novel therapeutic approach in IBD; Systemic LPS exposure

Inflammatory bowel disease [IBD] is accompanied by lesions in the epithelial barrier, which allow translocation of bacterial products from the gut lumen to the host's circulation. IMM-124E is a colostrum-based product containing high levels of anti-E.coli-LPS IgG, and might limit exposure to ba...