“Normal values” for the lymphocyte cytokinesis-block micronucleus cytome parameters: Repeatability and reproducibility in a healthy reference population

• Published in: The Science of the total environment Vol. 652; pp. 513 - 522
• Main Authors: Bolognesi, Claudia, Bonelli, Luigina, Compalati, Andrea, Ferla, Valentina, Stagnaro, Laura, Ubezio, Gianluca, Bruzzi, Paolo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 20.02.2019
• Subjects: Biomarkers; Biomonitoring; blood sampling; Chromosomal instability; Cytokinesis; Cytome assay; diet; DNA Damage; Environmental Monitoring; Female; females; Healthy subjects; human population; Humans; lifestyle; Lymphocytes; Male; males; Micronucleus; micronucleus tests; Micronucleus Tests - methods; Micronucleus Tests - standards; mutagens; neoplasms; normal values; Occupational exposure; Reference Values; Reproducibility of Results; risk; Healthy subjects; Biomonitoring; Chromosomal instability; Occupational exposure; Cytome assay; Micronucleus

The micronucleus test in peripheral blood lymphocytes is the most widely validated technique to evaluate the DNA damage and chromosomal instability in human populations. The test is largely applied in monitoring environmental and occupational exposure to genotoxic agents. It was also proposed as a b...