Cytotoxicity, apoptosis and study of the DNA-binding properties of bi- and tetranuclear gallium(III) complexes with heterocyclic thiolato ligands

• Published in: Investigational new drugs Vol. 29; no. 5; pp. 932 - 944
• Main Authors: Gallego, Beatriz, Kaluđerović, Milena R., Kommera, Harish, Paschke, Reinhard, Hey-Hawkins, Evamarie, Remmerbach, Torsten W., Kaluđerović, Goran N., Gómez-Ruiz, Santiago
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.10.2011; Springer Nature B.V
• Subjects: Apoptosis; Apoptosis - drug effects; Cancer therapies; Caspases - metabolism; Cell Line, Tumor; Cell Survival - drug effects; Chemotherapy; Crystallography, X-Ray; Cytotoxicity; DNA - metabolism; DNA Fragmentation - drug effects; Drug Screening Assays, Antitumor; Drugs; Gallium - pharmacology; Heterocyclic Compounds - chemical synthesis; Heterocyclic Compounds - chemistry; Heterocyclic Compounds - pharmacology; Humans; Inhibitory Concentration 50; Ligands; Medicine; Medicine & Public Health; Models, Molecular; Nitrates; Oncology; Ovarian cancer; Pharmacology; Pharmacology/Toxicology; Plasmids - genetics; Preclinical Studies; Spectrophotometry, Ultraviolet; Studies; Sulfhydryl Compounds - chemical synthesis; Sulfhydryl Compounds - chemistry; Sulfhydryl Compounds - pharmacology; Thyroid cancer; Europe; Anticancer drugs; Thiolato ligands; Cytotoxicity; Gallium; Apoptosis

Summary The reaction of the heterocyclic thiol derivatives, 2-mercapto-1-methylimidazole (SH-imi), 5-mercapto-1-methyltetrazole (SH-tet), 2-mercaptobenzothiazole (SH-ben) and 5-phenyl-1,3,4-oxadiazole-2-thiol (SH-oxa), with trimethylgallium (1:1) afforded the dimeric or tetrameric complexes [Me 2 Ga...