The transcriptome of early GGT/KRT19-positive hepatocellular carcinoma reveals a downregulated gene expression profile associated with fatty acid metabolism

• Published in: Genomics (San Diego, Calif.) Vol. 114; no. 1; pp. 72 - 83
• Main Authors: Castro-Gil, María Paulette, Torres-Mena, Julia Esperanza, Salgado, Rosa M., Muñoz-Montero, Said A., Martínez-Garcés, José Michael, López-Torres, Carlos David, Mendoza-Vargas, Alfredo, Gabiño-López, Nayeli Belem, Villa-Treviño, Saúl, del Pozo-Yauner, Luis, Arellanes-Robledo, Jaime, Krötzsch, Edgar, Pérez-Carreón, Julio Isael
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2022
• Subjects: Carcinoma, Hepatocellular - metabolism; Dysplastic nodules; Fatty Acids; Humans; Laser capture microdissection; Liver cancer; Liver Neoplasms - metabolism; NRF2 activation; Retinoid X Receptor alpha - genetics; Retinoid X Receptor alpha - metabolism; RNA-sequencing; RXRα function; Transcriptome; RNA-sequencing; Liver cancer; RXRα function; Laser capture microdissection; Dysplastic nodules; NRF2 activation

Hepatocellular carcinoma expressing hepatobiliary progenitor markers, is considered of poor prognosis. By using a hepatocarcinogenesis model, laser capture microdissection, and RNA-Sequencing analysis, we identified an expression profile in GGT/KRT19-positive experimental tumors; 438 differentially...