The influence of hormone replacement therapy on lung cancer incidence and mortality

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 159; no. 4; pp. 1546 - 1556.e4
• Main Authors: Titan, Ashley L., He, Hao, Lui, Natalie, Liou, Douglas, Berry, Mark, Shrager, Joseph B., Backhus, Leah M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2020
• Subjects: Aged; Carcinoma, Non-Small-Cell Lung - epidemiology; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - therapy; Cohort Studies; Female; Hormone Replacement Therapy; Humans; Incidence; Kaplan-Meier Estimate; Lung Neoplasms - epidemiology; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Middle Aged; non–small cell lung cancer; Proportional Hazards Models; smoking; Survival Rate; NSCLC; smoking; non–small cell lung cancer; hormone replacement therapy; WHI; HRT; OCP; PLCO

Data regarding the effects of hormone replacement therapy (HRT) on non–small cell lung cancer (NSCLC) are mixed. We hypothesized HRT would have a protective benefit with reduced NSCLC incidence among women in a large, prospective cohort. We used data from the multicenter randomized Prostate, Lung, C...