Effect of eliglustat on the pharmacokinetics of digoxin, metoprolol, and oral contraceptives and absorption of eliglustat when coadministered with acid-reducing agents - Thibault, Nathan; Ibrahim, Jennifer; Peterschmitt, M. Judith; Puga, Ana Cristina; Ross, Leorah; Vu, Lucie; Xue, Yong; Turpault, Sandrine (Molecular genetics and metabolism, 2020)
Keywords: Acid-reducing agents; Adolescent; Adult; Contraceptives, Oral - administration & dosage; Contraceptives, Oral - adverse effects; Contraceptives, Oral - pharmacokinetics; Cross-Over Studies; CYP2D6 metabolism; Digoxin; Digoxin - administration & dosage; Digoxin - adverse effects; Digoxin - pharmacokinetics; Drug Interactions; Eliglustat; Female; Humans; Male; Metoprolol; Metoprolol - administration & dosage; Metoprolol - adverse effects; Metoprolol - pharmacokinetics; Middle Aged; Oral contraceptives; Pharmacokinetics; Proton Pump Inhibitors - administration & dosage; Proton Pump Inhibitors - adverse effects; Pyrrolidines - administration & dosage; Young Adult; CYP2D6 metabolism; Metoprolol; Digoxin; Acid-reducing agents; Drug interactions; Eliglustat; Pharmacokinetics; Oral contraceptives