Targeted multifunctional nanomaterials with MRI, chemotherapy and photothermal therapy for the diagnosis and treatment of bladder cancer

• Published in: Biomaterials science Vol. 8; no. 1; pp. 342 - 352
• Main Authors: Tao, Kepeng, Liu, Shuwei, Wang, Lu, Qiu, Heping, Li, Binxi, Zhang, Mengsi, Guo, Mengyuan, Liu, Heng, Zhang, Xue, Liu, Yi, Hou, Yuchuan, Zhang, Hao
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 01.01.2020
• Subjects: Ablation; Absorption spectra; Animals; Biocompatibility; Bladder; Bladder cancer; Blood circulation; Cancer; Cancer therapies; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemotherapy; Combined Modality Therapy; Folic acid; Folic Acid - administration & dosage; Folic Acid - pharmacokinetics; Functional materials; Half-Life; HeLa Cells; Humans; Iron oxides; Magnetic Resonance Imaging; Magnetite Nanoparticles; Mice; Nanomaterials; NMR; Nuclear magnetic resonance; Organs; Phototherapy - methods; Side effects; Theranostic Nanomedicine - methods; Treatment Outcome; Tumors; Urinary Bladder Neoplasms - diagnosis; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - therapy; Urinary tract; Vincristine - administration & dosage; Vincristine - pharmacokinetics; Xenograft Model Antitumor Assays

Bladder cancer is a common urinary tract tumor in clinic, and its morbidity and mortality are always high. Surgical treatment is operator dependent, residual tumor cells often lead to tumor recurrence, and chemotherapy after surgery causes high side effects. So, it is urgent to develop new methods f...