The effects of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes

We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes. This study was a randomized, double-blind, placebo-controlled clinical trial. Subjects with prediabetes were randomly assigned to the GO2KA1 intervention group or the...

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Published inFood & function Vol. 5; no. 1; pp. 2662 - 2669
Main Authors Kim, Hee Jun, Ahn, Hyeon Yeong, Kwak, Jung Hyun, Shin, Dong Yeob, Kwon, Young-In, Oh, Chen-Gum, Lee, Jong Ho
Format Journal Article
LanguageEnglish
Published England 01.10.2014
Subjects
Adiponectin - blood
Adult
Aged
Asian Continental Ancestry Group
Biomarkers - blood
Blood Glucose - metabolism
Body Mass Index
C-Peptide - blood
Chitosan - administration & dosage
Chitosan - chemistry
Cholesterol - blood
Dietary Supplements
Double-Blind Method
Energy Intake
Female
Glucose Tolerance Test
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - chemistry
Insulin - blood
Interleukin-6 - blood
Male
Middle Aged
Oligosaccharides - administration & dosage
Oligosaccharides - chemistry
Postprandial Period - drug effects
Prediabetic State - prevention & control
Triglycerides - blood
Tumor Necrosis Factor-alpha - blood
Young Adult
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Abstract We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes. This study was a randomized, double-blind, placebo-controlled clinical trial. Subjects with prediabetes were randomly assigned to the GO2KA1 intervention group or the placebo group for 12 weeks. We assessed the serum levels of glucose, insulin, and C-peptide by a 2 hour value in the 75 g oral glucose tolerance test (OGTT), HbA1c, pro-inflammatory cytokines, and plasma adiponectin at baseline and after the 12 week intervention. The treatment group showed a significant decrease in the serum glucose level at 30 min ( p = 0.013) and at 60 min ( p = 0.028). The change of the serum glucose level at 60 min was significant in the treatment group compared with the placebo group ( p = 0.030). Also, the plasma level of HbA1c ( p = 0.023) and the pro-inflammatory cytokines (IL-6 and TNF-α) were reduced and plasma adiponectin was increased in the GO2KA1 intervention group after the 12 week treatment. However, the placebo group did not show any significant changes in these biomarkers. In subjects with prediabetes, 12 week supplement with GO2KA1 may help control postprandial glucose compared with control. We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes.
AbstractList We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes. This study was a randomized, double-blind, placebo-controlled clinical trial. Subjects with prediabetes were randomly assigned to the GO2KA1 intervention group or the placebo group for 12 weeks. We assessed the serum levels of glucose, insulin, and C-peptide by a 2 hour value in the 75 g oral glucose tolerance test (OGTT), HbA1c, pro-inflammatory cytokines, and plasma adiponectin at baseline and after the 12 week intervention. The treatment group showed a significant decrease in the serum glucose level at 30 min (p = 0.013) and at 60 min (p = 0.028). The change of the serum glucose level at 60 min was significant in the treatment group compared with the placebo group (p = 0.030). Also, the plasma level of HbA1c (p = 0.023) and the pro-inflammatory cytokines (IL-6 and TNF-α) were reduced and plasma adiponectin was increased in the GO2KA1 intervention group after the 12 week treatment. However, the placebo group did not show any significant changes in these biomarkers. In subjects with prediabetes, 12 week supplement with GO2KA1 may help control postprandial glucose compared with control.
We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes. This study was a randomized, double-blind, placebo-controlled clinical trial. Subjects with prediabetes were randomly assigned to the GO2KA1 intervention group or the placebo group for 12 weeks. We assessed the serum levels of glucose, insulin, and C-peptide by a 2 hour value in the 75 g oral glucose tolerance test (OGTT), HbA1c, pro-inflammatory cytokines, and plasma adiponectin at baseline and after the 12 week intervention. The treatment group showed a significant decrease in the serum glucose level at 30 min (p = 0.013) and at 60 min (p = 0.028). The change of the serum glucose level at 60 min was significant in the treatment group compared with the placebo group (p = 0.030). Also, the plasma level of HbA1c (p = 0.023) and the pro-inflammatory cytokines (IL-6 and TNF-α) were reduced and plasma adiponectin was increased in the GO2KA1 intervention group after the 12 week treatment. However, the placebo group did not show any significant changes in these biomarkers. In subjects with prediabetes, 12 week supplement with GO2KA1 may help control postprandial glucose compared with control.We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes. This study was a randomized, double-blind, placebo-controlled clinical trial. Subjects with prediabetes were randomly assigned to the GO2KA1 intervention group or the placebo group for 12 weeks. We assessed the serum levels of glucose, insulin, and C-peptide by a 2 hour value in the 75 g oral glucose tolerance test (OGTT), HbA1c, pro-inflammatory cytokines, and plasma adiponectin at baseline and after the 12 week intervention. The treatment group showed a significant decrease in the serum glucose level at 30 min (p = 0.013) and at 60 min (p = 0.028). The change of the serum glucose level at 60 min was significant in the treatment group compared with the placebo group (p = 0.030). Also, the plasma level of HbA1c (p = 0.023) and the pro-inflammatory cytokines (IL-6 and TNF-α) were reduced and plasma adiponectin was increased in the GO2KA1 intervention group after the 12 week treatment. However, the placebo group did not show any significant changes in these biomarkers. In subjects with prediabetes, 12 week supplement with GO2KA1 may help control postprandial glucose compared with control.
We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes. This study was a randomized, double-blind, placebo-controlled clinical trial. Subjects with prediabetes were randomly assigned to the GO2KA1 intervention group or the placebo group for 12 weeks. We assessed the serum levels of glucose, insulin, and C-peptide by a 2 hour value in the 75 g oral glucose tolerance test (OGTT), HbA1c, pro-inflammatory cytokines, and plasma adiponectin at baseline and after the 12 week intervention. The treatment group showed a significant decrease in the serum glucose level at 30 min ( p = 0.013) and at 60 min ( p = 0.028). The change of the serum glucose level at 60 min was significant in the treatment group compared with the placebo group ( p = 0.030). Also, the plasma level of HbA1c ( p = 0.023) and the pro-inflammatory cytokines (IL-6 and TNF-α) were reduced and plasma adiponectin was increased in the GO2KA1 intervention group after the 12 week treatment. However, the placebo group did not show any significant changes in these biomarkers. In subjects with prediabetes, 12 week supplement with GO2KA1 may help control postprandial glucose compared with control. We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes.
We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes. This study was a randomized, double-blind, placebo-controlled clinical trial. Subjects with prediabetes were randomly assigned to the GO2KA1 intervention group or the placebo group for 12 weeks. We assessed the serum levels of glucose, insulin, and C-peptide by a 2 hour value in the 75 g oral glucose tolerance test (OGTT), HbA1c, pro-inflammatory cytokines, and plasma adiponectin at baseline and after the 12 week intervention. The treatment group showed a significant decrease in the serum glucose level at 30 min (p= 0.013) and at 60 min (p= 0.028). The change of the serum glucose level at 60 min was significant in the treatment group compared with the placebo group (p= 0.030). Also, the plasma level of HbA1c (p= 0.023) and the pro-inflammatory cytokines (IL-6 and TNF- alpha ) were reduced and plasma adiponectin was increased in the GO2KA1 intervention group after the 12 week treatment. However, the placebo group did not show any significant changes in these biomarkers. In subjects with prediabetes, 12 week supplement with GO2KA1 may help control postprandial glucose compared with control.
Author Kwon, Young-In
Oh, Chen-Gum
Kim, Hee Jun
Lee, Jong Ho
Kwak, Jung Hyun
Shin, Dong Yeob
Ahn, Hyeon Yeong
AuthorAffiliation Graduate School
Department of Food and Nutrition
Department of Internal Medicine
National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics
Kunpoong Bio Co., Ltd
Hannam University
Interdisciplinary Course of Science for Aging
Brain Korea 21 PLUS Project
Research Institute of Science for Aging
College of Human Ecology
Yonsei University
College of Medicine
Endocrinology
AuthorAffiliation_xml – name: Kunpoong Bio Co., Ltd
– name: Endocrinology
– name: Brain Korea 21 PLUS Project
– name: Department of Internal Medicine
– name: Yonsei University
– name: National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics
– name: College of Medicine
– name: Research Institute of Science for Aging
– name: Interdisciplinary Course of Science for Aging
– name: Department of Food and Nutrition
– name: Hannam University
– name: Graduate School
– name: College of Human Ecology
Author_xml – sequence: 1
  givenname: Hee Jun
  surname: Kim
  fullname: Kim, Hee Jun
– sequence: 2
  givenname: Hyeon Yeong
  surname: Ahn
  fullname: Ahn, Hyeon Yeong
– sequence: 3
  givenname: Jung Hyun
  surname: Kwak
  fullname: Kwak, Jung Hyun
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  givenname: Dong Yeob
  surname: Shin
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  surname: Kwon
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  surname: Oh
  fullname: Oh, Chen-Gum
– sequence: 7
  givenname: Jong Ho
  surname: Lee
  fullname: Lee, Jong Ho
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Snippet We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes. This study was a...
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SubjectTerms Adiponectin - blood
Adult
Aged
Asian Continental Ancestry Group
Biomarkers - blood
Blood Glucose - metabolism
Body Mass Index
C-Peptide - blood
Chitosan - administration & dosage
Chitosan - chemistry
Cholesterol - blood
Dietary Supplements
Double-Blind Method
Energy Intake
Female
Glucose Tolerance Test
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - chemistry
Insulin - blood
Interleukin-6 - blood
Male
Middle Aged
Oligosaccharides - administration & dosage
Oligosaccharides - chemistry
Postprandial Period - drug effects
Prediabetic State - prevention & control
Triglycerides - blood
Tumor Necrosis Factor-alpha - blood
Young Adult
Title The effects of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes
URI https://www.ncbi.nlm.nih.gov/pubmed/25222285
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