Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized Trial

• Published in: The Journal of pediatrics Vol. 202; pp. 179 - 185.e4
• Main Authors: Alonso, Estella M., Ye, Wen, Hawthorne, Kieran, Venkat, Veena, Loomes, Kathleen M., Mack, Cara L., Hertel, Paula M., Karpen, Saul J., Kerkar, Nanda, Molleston, Jean P., Murray, Karen F., Romero, Rene, Rosenthal, Philip, Schwarz, Kathleen B., Shneider, Benjamin L., Suchy, Frederick J., Turmelle, Yumirle P., Wang, Kasper S., Sherker, Averell H., Sokol, Ronald J., Bezerra, Jorge A., Magee, John C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2018
• Subjects: Adrenal Cortex Hormones - adverse effects; Adrenal Cortex Hormones - therapeutic use; Biliary Atresia - drug therapy; Biliary Atresia - mortality; Biliary Atresia - surgery; Body Weight - drug effects; Cephalometry - methods; Child Development - drug effects; Child Development - physiology; Child, Preschool; chronic liver disease; Double-Blind Method; failure to thrive; Failure to Thrive - chemically induced; Failure to Thrive - epidemiology; Failure to Thrive - physiopathology; Female; Follow-Up Studies; Humans; Infant; Male; Monitoring, Physiologic - methods; Portoenterostomy, Hepatic - methods; Portoenterostomy, Hepatic - mortality; Postoperative Care - methods; Prospective Studies; Reference Values; Risk Assessment; sarcopenia; Sarcopenia - chemically induced; Sarcopenia - epidemiology; Sarcopenia - physiopathology; Time Factors; Treatment Outcome; chronic liver disease; START; HPE; ChiLDReN; sarcopenia; failure to thrive

To investigate the impact of corticosteroid therapy on the growth of participants in the Steroids in Biliary Atresia Randomized Trial (START) conducted through the Childhood Liver Disease Research Network. The primary analysis in START indicated that steroids did not have a beneficial effect on drai...