A novel viscoelastic microfluidic platform for nanoparticle/small extracellular vesicle separation through viscosity gradient-induced migration

• Published in: Biomicrofluidics Vol. 18; no. 3; pp. 034107 - 34117
• Main Authors: Guo, Han, Wang, Dayin, Feng, Shilun, Zhang, Kaihuan, Luo, Yuan, Zhao, Jianlong
• Format: Journal Article
• Language: English
• Published: United States American Institute of Physics 01.05.2024; AIP Publishing LLC
• Subjects: Complexity; Context; Extracellular vesicles; Fluorescence; Microfluidics; Nanoparticles; Nucleic acids; Qualitative analysis; Recovery; Regular; Separation; Vesicles; Viscoelasticity; Viscosity

Small extracellular vesicles (sEVs) are extracellular vesicles with diameters ranging from 30 to 150 nm, harboring proteins and nucleic acids that reflect their source cells and act as vital mediators of intercellular communication. The comprehensive analysis of sEVs is hindered by the complex compo...