Comparison of Topical and Intravenous Administration of WIN 55-212-2 in Normotensive Rabbits
Objective: This study compares the effect of topical versus intravenous (IV) administration of synthetic WIN 55-212-2 (WIN) or timolol on intraocular pressure (IOP). Methods: WIN or timolol were administered either topically or by IV in normotensive New Zealand white rabbits. IOP was measured at bas...
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Published in | Current eye research Vol. 33; no. 10; pp. 857 - 863 |
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01.01.2008
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Abstract | Objective: This study compares the effect of topical versus intravenous (IV) administration of synthetic WIN 55-212-2 (WIN) or timolol on intraocular pressure (IOP). Methods: WIN or timolol were administered either topically or by IV in normotensive New Zealand white rabbits. IOP was measured at baseline and 30, 60, and 120 min after administration (n = 4 per group). Blood pressure (BP) and heart rate (HR) were measured concomitantly with IOP. Results: IV administration of 0.1 mg/kg WIN reduced IOP by 30% after 30 min, which continued to decline for up to 120 min. Timolol injection (25 μ g/kg) also reduced IOP by 25% after 30 min but was not sustained. In comparison, both topical WIN (1.0%) and timolol (0.5%) reduced IOP by 20% from baseline after 30 min. IV injection of either WIN or timolol significantly reduced HR to 155.4 ± 11.4 bpm and 165.9 ± 11.1 bpm, respectively, from a baseline of 256.3 ± 9.9 bpm. Topical administration was well tolerated and did not affect behavior, BP, or HR. Conclusion: Topical administration of either WIN or timolol did not decrease IOP as much as IV administration, but the lack of systemic or local toxicity could make it the safer alternative. |
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AbstractList | This study compares the effect of topical versus intravenous (IV) administration of synthetic WIN 55-212-2 (WIN) or timolol on intraocular pressure (IOP).
WIN or timolol were administered either topically or by IV in normotensive New Zealand white rabbits. IOP was measured at baseline and 30, 60, and 120 min after administration (n = 4 per group). Blood pressure (BP) and heart rate (HR) were measured concomitantly with IOP.
IV administration of 0.1 mg/kg WIN reduced IOP by 30% after 30 min, which continued to decline for up to 120 min. Timolol injection (25 mu g/kg) also reduced IOP by 25% after 30 min but was not sustained. In comparison, both topical WIN (1.0%) and timolol (0.5%) reduced IOP by 20% from baseline after 30 min. IV injection of either WIN or timolol significantly reduced HR to 155.4 +/- 11.4 bpm and 165.9 +/- 11.1 bpm, respectively, from a baseline of 256.3 +/- 9.9 bpm. Topical administration was well tolerated and did not affect behavior, BP, or HR.
Topical administration of either WIN or timolol did not decrease IOP as much as IV administration, but the lack of systemic or local toxicity could make it the safer alternative. Objective: This study compares the effect of topical versus intravenous (IV) administration of synthetic WIN 55-212-2 (WIN) or timolol on intraocular pressure (IOP). Methods: WIN or timolol were administered either topically or by IV in normotensive New Zealand white rabbits. IOP was measured at baseline and 30, 60, and 120 min after administration (n = 4 per group). Blood pressure (BP) and heart rate (HR) were measured concomitantly with IOP. Results: IV administration of 0.1 mg/kg WIN reduced IOP by 30% after 30 min, which continued to decline for up to 120 min. Timolol injection (25 μ g/kg) also reduced IOP by 25% after 30 min but was not sustained. In comparison, both topical WIN (1.0%) and timolol (0.5%) reduced IOP by 20% from baseline after 30 min. IV injection of either WIN or timolol significantly reduced HR to 155.4 ± 11.4 bpm and 165.9 ± 11.1 bpm, respectively, from a baseline of 256.3 ± 9.9 bpm. Topical administration was well tolerated and did not affect behavior, BP, or HR. Conclusion: Topical administration of either WIN or timolol did not decrease IOP as much as IV administration, but the lack of systemic or local toxicity could make it the safer alternative. |
Author | Samudre, Sandeep S. Lattanzio, Frank A. Pratap, Kiran Schneider, Jennifer L. Sheppard, John D. Loose-Thurman, Patricia Oltmanns, Matthew H. Hosseini, Alireza Allen, Robert C. Williams, Patricia B. |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18853319$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1007_s12012_023_09810_9 crossref_primary_10_1016_j_biopha_2022_112981 crossref_primary_10_1016_j_bmc_2018_11_003 crossref_primary_10_1089_jop_2017_0037 crossref_primary_10_1089_jop_2011_0041 crossref_primary_10_1097_IJG_0000000000000746 |
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Snippet | Objective: This study compares the effect of topical versus intravenous (IV) administration of synthetic WIN 55-212-2 (WIN) or timolol on intraocular pressure... This study compares the effect of topical versus intravenous (IV) administration of synthetic WIN 55-212-2 (WIN) or timolol on intraocular pressure (IOP). WIN... |
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SubjectTerms | Administration, Topical Animals Benzoxazines - administration & dosage Benzoxazines - adverse effects Blood Pressure - drug effects Cannabinoids - administration & dosage Cannabinoids - adverse effects Dose-Response Relationship, Drug Female Heart Rate - drug effects Injections, Intravenous Intraocular Pressure - drug effects intravenous Morpholines - administration & dosage Morpholines - adverse effects Naphthalenes - administration & dosage Naphthalenes - adverse effects Rabbits Timolol - administration & dosage Tocrisolve Tonometry, Ocular topical WIN 55-212-2 |
Title | Comparison of Topical and Intravenous Administration of WIN 55-212-2 in Normotensive Rabbits |
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