Pediatric reference intervals for 29 Ortho VITROS 5600 immunoassays using the CALIPER cohort of healthy children and adolescents

• Published in: Clinical chemistry and laboratory medicine Vol. 56; no. 2; pp. 327 - 340
• Main Authors: Higgins, Victoria, Fung, Angela W.S., Chan, Man Khun, Macri, Joseph, Adeli, Khosrow
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 26.01.2018; Walter De Gruyter & Company
• Subjects: 17β-Estradiol; Adolescent; Adolescents; Age; Antigens; Biomarkers; Biomarkers - blood; Cancer; Child; Child, Preschool; Children; Chorionic gonadotropin; Cohort Studies; Confidence intervals; Creatine; Creatine kinase; Female; Ferritin; Follicle-stimulating hormone; Gender aspects; Gonadotropins; Guidelines; Healthy Volunteers; Humans; IgG antibody; Immunoassay; Immunoassay - standards; Immunoassay - statistics & numerical data; Immunoassays; Immunoglobulin G; Infant; Infant, Newborn; Kinases; Laboratories; Laboratory tests; Luteinizing hormone; Male; Myoglobins; Organic chemistry; Outliers (statistics); Parathyroid; Parathyroid hormone; pediatric; Pediatrics; Pediatrics - statistics & numerical data; Pituitary (anterior); Progesterone; Prostate; Prostate cancer; Prostate-specific antigen; Puberty; reference intervals; Reference Values; Rubella; Sex; Sex Characteristics; Sex differences; Sex hormones; Sexual Maturation; Testosterone; Thyroid; Thyroid gland; Thyroid hormones; Thyroxine; Vitamin D; immunoassays; reference intervals; pediatric

Accurate reference intervals (RIs) based on a healthy pediatric population are essential for pediatric test result interpretation. The CALIPER project has recruited a large healthy cohort and completed a series of a priori studies to address gaps in pediatric RIs. As immunoassays from different manu...